“…35,37,40,[45][46][47][48]56,57,[59][60][61][62][63][64][65] All were simple case-series. Nine studies were in adults, 37,40,45,46,56,57,60,63,65 two studies in both adults and children, 47,64 and in the remainder of the studies the age of the study population was not specified. 35,48,59,61,62 Of the 16 studies, all measured abnormality rates, ten measured impact on clinical management, 35,37,40,45,47,48,59,61,63,64 and five measured the number of adverse events in patients with an abnormal test finding.…”