The utility of GLUT1 as a diagnostic marker in cutaneous vascular anomalies: A review of literature and recommendations for daily practice

Vugt, Lieke J. van; Vleuten, C.J.M. van der; Flucke, Uta; Blokx, Willeke A.M.

doi:10.1016/j.prp.2017.04.023

Cited by 49 publications

(27 citation statements)

References 29 publications

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“…This tool is considered as a helpful additional indicator for diagnosing HEM (3). However, this positive result is also possible for other vascular lesions, including epitheloid hemangioendotheliomas, angiosarcomas, and angiokeratomas; so, the final diagnosis for HEM should be made through the interpretation of all clinical and diagnostic features, and not based on GLUT-1 staining alone (6,39).…”

Section: Discussionmentioning

confidence: 99%

Management of the oral hemangiomas in infants and children: Scoping review

Barrón-Peña

Ma²,

Benítez-Cárdenas³

et al. 2020

Med Oral

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Background: Pediatric oral hemangiomas are benign vascular tumors that can be seen from birth, particularly in females. Hemangiomas are most frequent located in the lips and usually regress spontaneously, thus they do not require any type of treatment in most cases. The present scoping review pretended to synthesize the most relevant and currently available information from the international dental literature published in the last 25 years, regarding the management of pediatric oral hemangiomas. Material and Methods: An exhaustive literature search was performed in four electronic databases (PubMed, Embase, Google Scholar, and Cochrane). Initially, 241 related titles and abstracts were found. After the duplication removal, screening, and assessment processes, 37 records were included for full-text reading. Finally, 20 articles in the English language were included in the scoping review for data extraction and assessment. Results: We identified and subsequently discussed three fundamental issues associated to the management of pediatric oral hemangiomas: (i) clinical characteristics, differential diagnosis, and histopathological findings; (ii) evolution and complications; and (iii) current available treatment modalities. Conclusions: Although these like-tumor lesions are uncommon, pediatric dentistry practitioners must be familiar with the inherent clinical characteristics, diagnosis approaches, and currently available treatment options. Nowadays, surgical removal and non-invasive medical/pharmacologic therapies are the best management modalities for pediatric oral hemangiomas.

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Section: Discussionmentioning

confidence: 99%

Management of the oral hemangiomas in infants and children: Scoping review

Barrón-Peña

Ma²,

Benítez-Cárdenas³

et al. 2020

Med Oral

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“…GLUT1 is a useful marker for differentiation of infantile hemangiomas and other vascular neoplasms such as congenital hemangioma, tufted angioma and kaposiform hemangioendothelioma, being positive in the infantile hemangiomas and negative in the other entities [ 24 ]. A recent research highlighted that complete cases of microvenular hemangioma (n = 9) and congenital hemangiomas (n = 16) were found to be devoid of GLUT1 expression [ 25 ]. In a study, the positivity of GLUT1 was described in complete specimens with verrucous hemangioma, which was negative in our study [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

Immunoreactivity of Wilms tumor 1 (WT1) as an additional evidence supporting hemangiomatous rather than inflammatory origin in the etiopathogenesis of angiolymphoid hyperplasia with eosinophilia

Tokat

Lehman

Sezer

et al. 2018

Dermatol Pract Concept

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BackgroundAngiolymphoid hyperplasia with eosinophilia (ALHE) is a rare vascular proliferative disorder mainly located in the periauricular region. The etiopathogenesis of ALHE is unknown, and it is still controversial as to whether the entity represents a benign vascular neoplasm or an inflammatory process.AimRecently, the intracytoplasmic staining pattern of Wilms tumor 1 (WT1) on immunohistochemistry has highlighted true vascular neoplasms, such as microvenular hemangioma, tufted angioma, and spindle cell hemangioma, which has made it helpful to distinguish ALHE from vascular malformations, as there is a negative staining pattern in the other entities. We aimed to investigate the immunoreactivity of ALHE specimens for WT1 as well as glucose transporter protein 1 (GLUT1) immunohistochemistry, an important and sensitive marker for the diagnosis of infantile hemangioma, which recently has been described to label other hemangiomas, such as verrucous hemangioma.Material and methodsClinical data and histopathological specimens from patients diagnosed with ALHE were reviewed, and immunohistochemical staining and microscopic analysis for WT-1 and GLUT1 were performed.ResultsIntracytoplasmic endothelial staining of WT1 was detected in 19 of 20 ALHE specimens. GLUT1 was not detected in any ALHE specimen.ConclusionsWe conclude that ALHE may represent a true hemangioma (i.e., benign vascular neoplasia) characterized by an eosinophil- and lymphocyte-rich inflammatory component as opposed to the reactive inflammatory dermatosis with a positive intracytoplasmic staining pattern for WT1. As far as we are aware, WT1 staining for ALHE has not been described to date.

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“…Three paired samples were used, including tumor of proliferative IHs (abbreviated as T) and the normal tissues adjacent to but farther than 1 cm from the outermost edge of the tumors (abbreviated as S). The tumors were divided into two parts after excision: one part was flash-frozen in liquid nitrogen for subsequent experiments, and the other part was paraffin-embedded and sectioned for hematoxylin and eosin and immunohistochemical staining for glucose transporter 1 [16]. The tumors were reconfirmed by pathological examination (Figure 1), and the normal tissues were confirmed to be free of tumor invasion.…”

Section: Samplesmentioning

confidence: 99%

Characterization of Epigenetic and Transcriptional Landscape in Infantile Hemangiomas with ATAC-Seq and RNA-Seq

Chen

et al. 2020

Epigenomics

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Aim: This study was conducted to reveal epigenetic landscape in infantile hemangiomas (IHs) and identify transcription factors (TFs) and their downstream genes active in IHs. Materials & methods: We performed Assay for Transposase Accessible Chromatin (ATAC-seq) with RNA-seq in three pairs of IHs and their adjacent normal tissues. Functions of candidate TFs were investigated in human umbilical vein endothelial cells (HUVECs). Results: Chromatin of IH tissues is less compact. Some candidate genes and TFs were identified. In HUVECs, SPDEF inhibited cell viability and tube formation, and promoted apoptosis; SOX4 exerted the opposite effect. SPDEF may act through EPHA5, ZBTB46 and SASH1; SOX4 may act through MMP12 and HIVEP3. Conclusion: Epigenetics plays a role in IHs. SPDEF and SOX4 may act in IHs.

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The utility of GLUT1 as a diagnostic marker in cutaneous vascular anomalies: A review of literature and recommendations for daily practice

Cited by 49 publications

References 29 publications

Management of the oral hemangiomas in infants and children: Scoping review

Management of the oral hemangiomas in infants and children: Scoping review

Immunoreactivity of Wilms tumor 1 (WT1) as an additional evidence supporting hemangiomatous rather than inflammatory origin in the etiopathogenesis of angiolymphoid hyperplasia with eosinophilia

Characterization of Epigenetic and Transcriptional Landscape in Infantile Hemangiomas with ATAC-Seq and RNA-Seq

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