The Utility of Carbon Disulphide and Lawesson's Reagent for Synthesis of Different Fused Heterocycles for Antimicrobial Evaluation

Abstract

in Wiley Online Library (wileyonlinelibrary.com).Hexahydroquinolines 1a,b reacted with carbon disulphide in different conditions to yield the corresponding adducts 2a,b and 3a,b. Carrying out the same reactions in acetone as solvent produced the modified new products 4a,b. The interaction of pyrazolopyridine derivatives 5a-d with carbon disulphide under the same previous conditions furnished the isolated products 6a-d, 7a-d, and 8a-d. Studying the behavior of 1a,b or 5a-d toward Lawesson's reagent (LR) formed the final adducts 11a,b or 12a-d. The structure of synthesized compounds was confirmed with the spectroscopic and microanalytical data. The biological activities of 2a, 4a, 4b, 7a, 7c, 8d, 11a, 11b, 12b, and 12c were tested for antimicrobial evaluation.

Electrochemical corrosion behavior of nano-coated Ti-6Al-4V alloy by a novel chitosan nanoparticles /silver nanoparticles in artificial saliva solution

“…The antibacterial sensitivity of the two new coatings (CNP and SNP/CNP coating) were tested against EscherichiaColi (E-Coli which is negative to gram) and Staphylococcus aureus (S. aureus which is positive to gram) bacteria. By means of a reformed Kirby-Bauer disc diffusion scheme [16], where 100 µl of the test bacteria were developed in 10 ml of new prepared media and spread in a clean petri dish with incubation at 35-37 o C for 24-48 hours till they grew to a sum total of about 10 8 cells/ml for bacteria. The positive controls for antimicrobial sensitivity are Ampicillin Standard discs (Antibacterial agent), where the negative control is filter discs saturated with 10 µl of solvent (purified water).…”

Ethyl 6-amino-5-cyano-4-phenyl-2,4-dihydropyrano[2,3-c]pyrazole-3-carboxylate dimethyl sulfoxide monosolvate

“…For background to the biological activity of synthetic pyrano[2,3-c] pyrazole compounds, see: Nasr et al (2002); Ismail et al (2003); Foloppe et al (2006); Mohamed et al (2010); Zonouz et al (2012); Kuo et al (1984); Zaki et al (2006); Ahluwalia et al (1997); Bhavanarushi et al (2013). For the synthesis of the title compound, see: Brahmachari & Banerjee (2014).…”

Recent Advance in Development of 3-Methyl-4-Arylmethylene Isoxazole-5(4h)-Ones and 6-Amino-1,4-Dihydropyrano[2,3-C]-Pyrazole-5-Carbonitriles: Synthetic Applications and Pathways

“…. [72] www.wjpps.com [78] All synthesized compounds shows potent activity in Alzheimer's disease therapy.…”