The Utilisation of Standard Addition Method for The Determination of Ibuprofen in Liquid Dosage Form

Abstract

Objective: The use of the standard addition method is common in drug analysis protocols. This study aims to quantify the ibuprofen within a pharmaceutical liquid preparation with the aid of a standard addition method relying on robust studies employing the UV-Visible spectrophotometric techniques. Methods: The oral pediatric syrup liquid dosage form of ibuprofen (Brufen®), wear diluted and inoculated with predetermined spikes of the ibuprofen standards. Consequently, these prepared samples were analyzed, employing UV-Vis techniques. Results: The absorbance versus concentration standard curve was plotted for Brufen®. This curve shows good linearity. The regression coefficient of 0.9942. The Limit of detection (LOD = 3SD) and Limit of quantification (LOQ = 10SD) were found to be 0.00755 and 0.02517, respectively. The percent amount was found to be 101.533% of ibuprofen content. Conclusion: In conclusion, the researchers find the standard addition method as a reliable method to acquire rapid, economy, and validated the method for the quantitation of ibuprofen oral pediatric syrup dosage forms, thus, can be utilized in routine laboratory drug-analysis works.

Determination of Tetracycline in Capsule Dosage Form

“…spectrophotometer for such purpose. [3][4][5] In one study, the standard addition method was compared with the High-performance liquid chromatography (HPLC) analyses and the results were very closed. 6 Nevertheless, the UV-vis spectrophotometer is a principal tool for the day-by-day drug analyses work.…”