The utilisation of resolvins in medicine and tissue engineering

Blaudez, Fanny; Ivanovski, Sašo; Fournier, Benjamin; Vaquette, Cédryck

doi:10.1016/j.actbio.2021.11.047

Cited by 9 publications

(5 citation statements)

References 152 publications

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“…Exosomes or microvesicles have been proposed as transporting systems for drug delivery in the treatment of DFUs[ 37 ]. However, below the adequate levels of circulating Rv, bioavailability, and stability are common limitations and issues while using Rv and biopolymers[ 35 , 38 ]. Thus, there is a need to improve the delivery techniques to enhance the bioavailability and stability of Rv as well as their therapeutic efficacy.…”

Section: Inflammation-resolving Mediatorsmentioning

confidence: 99%

Future applications of exosomes delivering resolvins and cytokines in facilitating diabetic foot ulcer healing

Littig¹,

Moellmer²,

Agrawal³

et al. 2023

World J Diabetes

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Type 2 diabetes mellitus (T2DM) increases the risk of many lethal and debilitating conditions. Among them, foot ulceration due to neuropathy, vascular disease, or trauma affects the quality of life of millions in the United States and around the world. Physiological wound healing is stalled in the inflammatory phase by the chronicity of inflammation without proceeding to the resolution phase. Despite advanced treatment, diabetic foot ulcers (DFUs) are associated with a risk of amputation. Thus, there is a need for novel therapies to address chronic inflammation, decreased angiogenesis, and impaired granulation tissue formation contributing to the non-healing of DFUs. Studies have shown promising results with resolvins (Rv) and anti-inflammatory therapies that resolve inflammation and enhance tissue healing. But many of these studies have encountered difficulty in the delivery of Rv in terms of efficiency, tissue targetability, and immunogenicity. This review summarized the perspective of optimizing the therapeutic application of Rv and cytokines by pairing them with exosomes as a novel strategy for targeted tissue delivery to treat non-healing chronic DFUs. The articles discussing the T2DM disease state, current research on Rv for treating inflammation, the role of Rv in enhancing wound healing, and exosomes as a delivery vehicle were critically reviewed to find support for the proposition of using Rv and exosomes in combination for DFUs therapy. The literature reviewed suggests the beneficial role of Rv and exosomes and exosomes loaded with anti-inflammatory agents as promising therapeutic agents in ulcer healing.

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Section: Inflammation-resolving Mediatorsmentioning

confidence: 99%

Future applications of exosomes delivering resolvins and cytokines in facilitating diabetic foot ulcer healing

Littig¹,

Moellmer²,

Agrawal³

et al. 2023

World J Diabetes

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show abstract

“…Because of its potential to also cause harm, inflammatory responses are regulated in a very complex manner, depending in part on the initiating factors, the extent of the response that is needed (i.e., the size and location of the wound) and the ability to initiate the downregulation of the response via both removal of the inciting events and elaboration of anti-inflammatory molecules, such as resolvins and related molecules [ 24 , 25 , 26 , 27 ]. In “normal” circumstances, the inflammatory response can be acute in nature followed by a resolution.…”

Section: Introductionmentioning

confidence: 99%

Creating an Optimal In Vivo Environment to Enhance Outcomes Using Cell Therapy to Repair/Regenerate Injured Tissues of the Musculoskeletal System

Hart

Nakamura

2022

Biomedicines

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Following most injuries to a musculoskeletal tissue which function in unique mechanical environments, an inflammatory response occurs to facilitate endogenous repair. This is a process that usually yields functionally inferior scar tissue. In the case of such injuries occurring in adults, the injury environment no longer expresses the anabolic processes that contributed to growth and maturation. An injury can also contribute to the development of a degenerative process, such as osteoarthritis. Over the past several years, researchers have attempted to use cellular therapies to enhance the repair and regeneration of injured tissues, including Platelet-rich Plasma and mesenchymal stem/medicinal signaling cells (MSC) from a variety of tissue sources, either as free MSC or incorporated into tissue engineered constructs, to facilitate regeneration of such damaged tissues. The use of free MSC can sometimes affect pain symptoms associated with conditions such as OA, but regeneration of damaged tissues has been challenging, particularly as some of these tissues have very complex structures. Therefore, implanting MSC or engineered constructs into an inflammatory environment in an adult may compromise the potential of the cells to facilitate regeneration, and neutralizing the inflammatory environment and enhancing the anabolic environment may be required for MSC-based interventions to fulfill their potential. Thus, success may depend on first eliminating negative influences (e.g., inflammation) in an environment, and secondly, implanting optimally cultured MSC or tissue engineered constructs into an anabolic environment to achieve the best outcomes. Furthermore, such interventions should be considered early rather than later on in a disease process, at a time when sufficient endogenous cells remain to serve as a template for repair and regeneration. This review discusses how the interface between inflammation and cell-based regeneration of damaged tissues may be at odds, and outlines approaches to improve outcomes. In addition, other variables that could contribute to the success of cell therapies are discussed. Thus, there may be a need to adopt a Precision Medicine approach to optimize tissue repair and regeneration following injury to these important tissues.

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“…Therefore, an excessive inflammatory response must be resolved to prevent the onset of chronic inflammatory diseases and the restoration of the homeostasis of organisms [ 6 , 7 , 8 ]. The inflammatory resolution phase is characterized by the ceasing of a neutrophil infiltration, the recession of proinflammatory cytokines, and the elimination of fragments and foreign matters in the inflammatory response by efferocytosis [ 9 , 10 ]. Resolvins, acting as an "agonist", are metabolites of omega-3 fatty acids and together with martins, protectins, and lipoxins, they are collectively referred to as "special pro-decomposition mediators" (SPMs).…”

Section: Introductionmentioning

confidence: 99%

Roles of Resolvins in Chronic Inflammatory Response

Liu

Fan

Liu

et al. 2022

IJMS

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An inflammatory response is beneficial to the organism, while an excessive uncontrolled inflammatory response can lead to the nonspecific killing of tissue cells. Therefore, promoting the resolution of inflammation is an important mechanism for protecting an organism suffering from chronic inflammatory diseases. Resolvins are a series of endogenous lipid mediums and have the functions of inhibiting a leukocyte infiltration, increasing macrophagocyte phagocytosis, regulating cytokines, and alleviating inflammatory pain. By promoting the inflammation resolution, resolvins play an irreplaceable role throughout the pathological process of some joint inflammation, neuroinflammation, vascular inflammation, and tissue inflammation. Although a large number of experiments have been conducted to study different subtypes of resolvins in different directions, the differences in the action targets between the different subtypes are rarely compared. Hence, this paper reviews the generation of resolvins, the characteristics of resolvins, and the actions of resolvins under a chronic inflammatory response and clinical translation of resolvins for the treatment of chronic inflammatory diseases.

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The utilisation of resolvins in medicine and tissue engineering

Cited by 9 publications

References 152 publications

Future applications of exosomes delivering resolvins and cytokines in facilitating diabetic foot ulcer healing

Future applications of exosomes delivering resolvins and cytokines in facilitating diabetic foot ulcer healing

Creating an Optimal In Vivo Environment to Enhance Outcomes Using Cell Therapy to Repair/Regenerate Injured Tissues of the Musculoskeletal System

Roles of Resolvins in Chronic Inflammatory Response

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