The Using of Lucilia Cuprina Maggots in the Treatment of Diabetic Foot Wounds

Hassan, Mostafa I.; Hammad, Kotb M.; Fouda, Maged M. A.

doi:10.12816/0006451

Cited by 15 publications

(8 citation statements)

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“…This procedure has been tested in diabetic patients and in different animal models of DFUs. The results showed that after treatment with several cycles of maggots, the wound was completely free of bacterial contamination and healed, and new tissues to close the wound were formed [105,106].…”

Section: Treatments For Diabetic Foot Ulcersmentioning

confidence: 99%

Current Therapeutic Strategies in Diabetic Foot Ulcers

et al. 2019

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Diabetic foot ulcers (DFUs) are the fastest growing chronic complication of diabetes mellitus, with more than 400 million people diagnosed globally, and the condition is responsible for lower extremity amputation in 85% of people affected, leading to high-cost hospital care and increased mortality risk. Neuropathy and peripheral arterial disease trigger deformities or trauma, and aggravating factors such as infection and edema are the etiological factors for the development of DFUs. DFUs require identifying the etiology and assessing the co-morbidities to provide the correct therapeutic approach, essential to reducing lower-extremity amputation risk. This review focuses on the current treatment strategies for DFUs with a special emphasis on tissue engineering techniques and regenerative medicine that collectively target all components of chronic wound pathology.

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Section: Treatments For Diabetic Foot Ulcersmentioning

confidence: 99%

Current Therapeutic Strategies in Diabetic Foot Ulcers

et al. 2019

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“…Today, the recommended and widely used therapeutic maggots are those of Lucilia (= Phaenicia) sericata, the green bottle blowfly (Sherman et al, 2000 andNigam et al, 2006a); a facultative parasite that, in humans, only attacks necrotic tissues and do not burrow down into live flesh . Moreover, Lucilia cuprina showed effectiveness in the treatment of diabetic foot wounds (Paul et al, 2009;Tantawi et al, 2010 andHassan et al 2014). Clearly, considerable caution should be taken when selecting any other species of maggots for medicinal use as some calliphorids, however, cannot be used therapeutically for e.g., Cochliomyia macellaria, Cochliomyia hominovorax (screwworms) and Chrysomya megacephala (the common green bottle fly or oriental latrine fly) since they will attack healthy human tissues.…”

Section: Maggots Used For Medical Applicationsmentioning

confidence: 99%

“…The first study on the application of MT for wound debridement in Egypt was that on animals by Eve Iversen (Iversen, 2000). Moreover, Hassan et al (2014) used L. cuprina maggots for treatment of an artificial wound made in a diabetic foot of rabbit and observed that the wound was completely healed after 13 days.…”

Section: Situation and Use Of Maggot Therapy In Egyptmentioning

confidence: 99%

Maggot Therapy “Use of Fly Larvae for Treatment of Wounds”- A Review

Kenawy

Abdel-Hamid

2020

Egyptian Academic Journal of Biological Sciences, E. Medical En

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Several chronic wounds require alternative therapy in addition to the conventional ones. Maggot therapy (MT) is one of these alternatives. MT is one form of animal-based treatment options known as Biotherapy (medicinal use of live organisms). MT or Maggot debridement therapy (MDT) is the medical use of live maggots for cleaning chronic, nonhealing wounds or certain wounds that are not amenable to other forms of therapy. MT is achieved through maggots' secretion of proteolytic enzymes that liquefy the necrotic tissues and then feed on such tissues (wound debridement activity), wound disinfection (antimicrobial) activity and growth-promoting (wound healing) activity. MT has been used for centuries. Occasionally used since the 1930's and early 1940's and then in 2004, the Food and Drug Administration (FDA) approved maggots as a medical device that has been prescribed for patients in more than 200 hospitals in the United States. This article presents a review of published articles on the different aspects of MT (mainly the past and current uses, maggots used, how to apply maggots for wound treatments, advantages and disadvantages, problems and adverse reactions and its application in Egypt) that serves as a guide to health professionals who may be users of this form of treatment now and in the future.

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“…Surgical interventions include debridement, ridding the wound bed and surrounding wound margins of necrotic tissue [9,10], and pressure relief applications which use casting and individualized shoe inserts or postoperative shoes to reduce mechanical stress to the wound [11,12]. Biologic therapies include antimicrobial peptide applications [13][14][15][16] and a revival of larval treatment, which debride the wound without surgical involvement [17][18][19]. Antibiotic regimens include a wide array of mixtures and classes, such as, glycopeptides and beta-lactams, although the infectious agent generally establishes the antibiotic regimen [20,21].…”

Section: Introductionmentioning

confidence: 99%

Improved Wound Closure Rates and Mechanical Properties Resembling Native Skin in Murine Diabetic Wounds Treated with a Tropoelastin and Collagen Wound Healing Device

Kellar

Diller

Tabor

et al. 2020

Journal of Diabetes and Clinical Research

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Chronic wounds in patients suffering from type II diabetes mellitus (DMII) where wounds remain open with a complicated pathophysiology, healing, and recovery process is a public health concern. Normal wound healing plays a critical role in wound closure, restoration of mechanical properties, and the biochemical characteristics of the remodeled tissue. Biological scaffolds provide a tissue substitute to help facilitate wound healing by mimicking the extracellular matrix (ECM) of the dermis. In the current study an electrospun biomimetic scaffold, wound healing device (WHD), containing tropoelastin (TE) and collagen was synthesized to mimic the biochemical and mechanical characteristics of healthy human skin. The WHD was compared to a commercially available porcine small intestinal submucosa (SIS) matrix that has been used in both partial and full-thickness wounds, Oasis ® Wound Matrix. Using a diabetic murine model C57BKS.Cg-m+/+Leprdb/J mice (db/db) wound closure rates, histochemistry (CD31 and CD163), qPCR (GAPDH, TNF-α, NOS2, ARG1 and IL10), and mechanical testing of treated wound sites were evaluated. The WHD in a splinted, full thickness, diabetic murine wound healing model demonstrated skin organ regeneration, an enhanced rate of wound closure, decreased tissue inflammation, and a stronger and more durable remodeled tissue that more closely mimics native unwounded skin compared to the control device.

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The Using of Lucilia Cuprina Maggots in the Treatment of Diabetic Foot Wounds

Cited by 15 publications

References 0 publications

Current Therapeutic Strategies in Diabetic Foot Ulcers

Current Therapeutic Strategies in Diabetic Foot Ulcers

Maggot Therapy “Use of Fly Larvae for Treatment of Wounds”- A Review

Improved Wound Closure Rates and Mechanical Properties Resembling Native Skin in Murine Diabetic Wounds Treated with a Tropoelastin and Collagen Wound Healing Device

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