The usefulness of99mTc-hexamethylpropyleneamineoxime white blood cell scintigraphy in a patient with eosinophilic gastroenteritis

Imai, Erika; Kaminaga, Tatsuro; Kawasugi, Kazuo; Yokokawa, Tokuzo; Furui, Shigeru

doi:10.1007/bf03006675

Cited by 10 publications

(4 citation statements)

References 14 publications

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“…In patients presenting with antral eosinophilic gastritis, a string sign may be seen as a sign of gastric outlet obstruction [51]. A few studies have reported the usefulness of Tc-99m hexamethylpropyleneamine oxime (HMPAO) scintigraphy scanning in detection of active eosinophilic inflammation, extent of disease, and assessment of the response to treatment [72,73].…”

Section: Radiographic Evaluationmentioning

confidence: 99%

Eosinophilic Gastroenteritis and Colitis: a Comprehensive Review

Uppal

Kreiger

Kutsch

2015

Clinic Rev Allerg Immunol

151

136

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Eosinophilic gastrointestinal disorders, including eosinophilic esophagitis, gastroenteritis, and colitis, refer to a spectrum of clinical diseases that present with variable degrees of infiltration of the gastrointestinal tract by eosinophils in the absence of other known causes of tissue eosinophilia. Clinical symptoms and laboratory findings are usually non-specific and may or may not be accompanied by peripheral blood eosinophilia. The extent of eosinophilic infiltration of the gastrointestinal wall varies from mucosal to transmural and serosal involvement. Diagnosis requires presence of gastrointestinal symptoms, demonstration of gastrointestinal eosinophilia by biopsy, and exclusion of other known causes of tissue eosinophilia. Many studies have pointed toward the eosinophil as the major offender; however, the exact functional role of the eosinophil in the pathogenesis of eosinophilic gastrointestinal disorders remains unclear. The roles of T-helper-2 cytokines and other mediators, such as eotaxin-1 and interleukin-5, have gained significant importance in the pathobiology of eosinophilic gastrointestinal disorders. Current understanding of treatment is based on case reports and a few case series, as there is a lack of large prospective studies. Steroids are currently the mainstay of therapy, but the roles of other drugs such as leukotriene inhibitors, mast cell stabilizers, interleukin-5 inhibitors, and anti-immunoglobulin E, along with other targets in the immune pathway, are currently being explored.

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Section: Radiographic Evaluationmentioning

confidence: 99%

Eosinophilic Gastroenteritis and Colitis: a Comprehensive Review

Uppal

Kreiger

Kutsch

2015

Clinic Rev Allerg Immunol

151

136

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“…A “halo sign” and “araneid limb–like sign” can be observed on CT as secondary to bowel-wall layering, and both can help in differentiating between an inflammatory and neoplastic lesion 64,65. Radioisotope scan with technetium ( 99m Tc) hexamethylpropyleneamineoxime–labeled white blood cells provides a useful tool in assessing the extent of the disease and monitoring therapeutic response, but has little diagnostic value, as this method does not differentiate EGE from other causes of intestinal inflammation 66,67…”

Section: Diagnosismentioning

confidence: 99%

<p>Eosinophilic gastroenteritis: diagnosis and clinical perspectives</p>

Sunkara¹,

Rawla²,

Yarlagadda³

et al. 2019

CEG

128

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Eosinophilic gastroenteritis (EGE) is a digestive disorder in children and adults that is characterized by eosinophilic infiltration in the stomach and intestine. The underlying molecular mechanisms predisposing to this disease are unknown, but it seems that hypersensitivity response plays a major role in its pathogenesis, as many patients have a history of seasonal allergies, food sensitivities, asthma, and eczema. Symptoms and clinical presentations vary, depending on the site and layer of the gastrointestinal wall infiltrated by eosinophils. Laboratory results, radiological findings, and endoscopy can provide important diagnostic evidence for EGE; however, the cornerstone of the diagnosis remains the histological examination of gastric and duodenal specimens for evidence of eosinophilic infiltration (>20 eosinophils per high-power field), and finally clinicians make the diagnosis in correlation with and by exclusion of other disorders associated with eosinophilic infiltration. Although spontaneous remission is reported in around 30%–40% of EGE cases, most patients require ongoing treatment. The management options for this disorder include both dietary and pharmacological approaches, with corticosteroids being the mainstay of therapy and highly effective. The subsequent course is quite variable. Some patients have no recurrences, while a few experience recurrent symptoms during or immediately after corticosteroid interruption. An alternative therapeutic armamentarium includes mast-cell stabilizers, leukotriene antagonists, antihistamines, immunomodulators, and biological agents. In this review, we provide a summary of the different diagnostic tools utilized in practice, as well as the different therapeutic approaches available for EGE management.

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“…This method allows for the assessment of the disease process advancement in a given tissue, based on the increased recruitment of lymphocytes to the sites of active inflammation. However, it does not enable differentiation of the cause of inflammation; moreover, its availability is significantly limited, which makes it of no value in the diagnostic process of EGE [15][16][17][18][19].…”

Section: Radiological Diagnosticsmentioning

confidence: 99%

Eosinophilic gastroenteritis – a manifestation of an allergic disease in the gastrointestinal tract? Part 1. Epidemiology and diagnosis

Kuźmiński¹,

Rosada²,

Przybyszewska³

et al. 2023

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Eosinophilic gastroenteritis (EGE) is a relatively rare disease, but it should be considered whenever a patient presents with unexplained gastrointestinal symptoms that cannot be explained by parasitic infection or other gastrointestinal diseases characterized by eosinophilic infiltration. A high coexistence of EGE and allergic diseases has been documented. Diagnosis of EGE is based primarily on clinical, endoscopic, and histopathological findings. Glucocorticosteroids and other immunomodulatory drugs are the mainstay of treatment, but currently the greatest hope lies in biological drugs, which are undergoing intensive research. This disease is troublesome for the patient and significantly reduces the quality of life.

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The usefulness of99mTc-hexamethylpropyleneamineoxime white blood cell scintigraphy in a patient with eosinophilic gastroenteritis

Cited by 10 publications

References 14 publications

Eosinophilic Gastroenteritis and Colitis: a Comprehensive Review

Eosinophilic Gastroenteritis and Colitis: a Comprehensive Review

<p>Eosinophilic gastroenteritis: diagnosis and clinical perspectives</p>

Eosinophilic gastroenteritis – a manifestation of an allergic disease in the gastrointestinal tract? Part 1. Epidemiology and diagnosis

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