The Usefulness of Xuefu Zhuyu Tang for Patients with Angina Pectoris: A Meta‐Analysis and Systematic Review

Abstract

Objective. To evaluate the efficacy of Xuefu Zhuyu Tang (XFZYT) for treating angina pectoris (AP). Methods. Six databases were searched (up to December, 2013). Eligible randomized controlled trials (RCTs) evaluating the efficiency of XFZYT plus traditional antianginal medications (TAMs) compared with TAMs alone in patients with AP were included. The outcomes were relief of anginal symptoms (RAS) and improvement of electrocardiogram (ECG) and blood high-density lipoprotein cholesterol (HDL-C) level. Result. Finally 14 RCTs were included. There were evidences that XFZYT combined with TAMs was more effective in improving RAS (RR = 1.29; 95% CI = [1.20, 1.38]), ECG (RR = 1.37; 95% CI = [1.22, 1.54]), and blood HDL-C level (MD = 0.29 mmol/L; 95% CI = [0.23, 0.35]) compared with TAMs alone. Our meta-analysis also showed the pooled number needed to treat (NNT) of the group with stable angina pectoris (SAP) was smaller in improving RAS (4.2 versus 5.7) and ECG (3.1 versus 5.5) compared with the group with both SAP and unstable angina pectoris (UAP). Conclusion. Combination therapy with XFZYT and TAMs is more effective in treating AP compared with TAMs alone. And XFZYT may be a more suitable choice for the treatment of SAP. However, the findings should be interpreted with caution due to the mediocre methodological quality of the included RCTs.

Reduced Stroke Risk among Patients with Atrial Fibrillation Receiving Chinese Herbal Medicines Treatment: Analysis of Domestic Data in Taiwan

“…In practice, the use of these formulae depends on the location of stasis. The prescription of TQHXT focuses on the area above the neck [21], and XFZYT focuses on the chest [22,23]. As for GXZYT, it is commonly used to treat the stasis occurring between the diaphragm and lower abdomen [24], and STZYT is utilized to remove the stasis on the limbs and musculoskeletal system [25].…”

Advances in Research on the circRNA‐miRNA‐mRNA Network in Coronary Heart Disease Treated with Traditional Chinese Medicine

“…For instance, combination therapy with Xuefu Zhuyu decoction and traditional antianginal medications (TAMs) was more effective in treating angina pectoris than TAMs alone. Evidence has indicated that Xuefu Zhuyu decoction combined with TAMs was more effective in improving RAS (RR � 1.29; 95% CI � (1.20, 1.38)), ECG (RR � 1.37; 95% CI � (1.22, 1.54)), and blood HDL-C level (MD � 0.29 mmol/L; 95% CI � (0.23, 0.35)) compared with TAMs alone from a meta-analysis and systematic review of 14 randomized controlled trials [11]. ere was benefit in the use of Tongxinluo (TXL) capsule for secondary prevention after acute myocardial infarction (AMI).…”

Chinese Herbal Formula Xuefu Zhuyu for Stable Angina (CheruSA): Study Protocol for a Multicenter Randomized Controlled Trial

“…Moreover, XFZY can downregulate the expression of Forkhead box (FoxO) genes via silent information regulator 1 (SIRT 1), thus delaying ischemic heart disease [ 20 ]. A systematic review has shown that XFZY plus antianginal drugs is superior to antianginal drugs alone in mitigating symptoms, relieving myocardial ischemia, and decreasing low-density lipoprotein cholesterol (LDL-C) [ 21 ]. However, the review concluded that the included small-scale trials with poor methodological quality do not provide high-quality evidence of XFZY for the treatment of SA.…”