Advances in Research on the circRNA‐miRNA‐mRNA Network in Coronary Heart Disease Treated with Traditional Chinese Medicine

Abstract

There has been an increase in morbidity and mortality related to coronary heart disease (CHD) in China in recent years. Numerous clinical experiences and studies have shown that traditional Chinese medicine (TCM) plays an important role in the prevention, treatment, and prognosis of CHD. However, the mechanism of TCM in the treatment of CHD has not yet been elucidated. The circRNA-miRNA-mRNA network consists of miRNA that is competitively bound by circRNA, and miRNA regulates the transcription level of mRNA. Through literature review, we found that the circRNA-miRNA-mRNA network acts to contribute to certain effects to CHD such as myocardial hypertrophy, myocardial fibrosis, and heart failure. TCM contains constituents that act against CHD by antiatherosclerosis and apoptosis inhibition action, cardiac and cardiomyocyte protection, and these components also promote cell growth and protection of the vascular system by regulating miRNAs. Therefore, we consider that the circRNA-miRNA-mRNA network may be a new regulatory mechanism for the effective treatment of CHD by TCM.

Circular RNA CHST15 Sponges miR-155-5p and miR-194-5p to Promote the Immune Escape of Lung Cancer Cells Mediated by PD-L1

“…Circular RNAs (circRNAs), a category of non-coding RNAs, is featured by a covalently closed-loop structure and do not have the 5′ and 3′ ends normally contained in linear RNAs (8). In recent decades, evidence has increasingly proven that circRNAs play crucial parts in cancer development, including lung cancer (9)(10)(11). For example, CircZNF124 can promote the progression of nonsmall cell lung cancer cells by targeting mIR-337-3p (12); hsa_circ_0011780 inhibits the proliferation and metastasis of lung cancer (13); down-regulated CircABCB10 enhances the sensitivity of lung cancer cells to cisplatin (14); hsa_circ_0072083 could promote the effect of cisplatin on suppressing the growth of lung cancer (15).…”

Correlation between Mitochondrial Dysfunction, Cardiovascular Diseases, and Traditional Chinese Medicine

“…A large number of clinical experiences and studies have shown that TCM plays an important role in the prevention, treatment, and prognosis of CVD [ 93 ]. Previous studies by our team have shown that circRNAs are closely related to the pathological process of acute coronary syndrome via a mechanism that may be related to the up- or downregulation of circRNAs and miRNAs and the coexpression of circRNA-miRNA [ 94 ]. In addition, through literature review, we consider that the circRNA-miRNA-mRNA network may be a new regulatory mechanism for TCM to effectively treat CVD [ 93 ].…”

The Emerging Picture of the Roles of CircRNA-CDR1as in Cancer

“…Many studies have demonstrated that CDR1as is expressed abnormally in many cancer types (Pan et al, 2018;Su et al, 2018;Tanaka et al, 2019;Lin et al, 2020;Tian et al, 2020;Zhou et al, 2020). The expression of CDR1as is upregulated in most tumors, such as colorectal cancer, hepatocellular carcinoma and breast cancer, and it exerts a tumor-promoting effect (Tang et al, 2017;Weng et al, 2017;Xu et al, 2017;Yuan et al, 2019;Zhang Z. et al, 2020;Zhao Y. H. et al, 2020).…”

“…CircRNAs exert their function through several mechanisms (Geng et al, 2018;Patop and Kadener, 2018;Zhou et al, 2018;Arnaiz et al, 2019). Firstly, circRNAs can function as miRNA sponges and competitive endogenous RNAs to modulate the activity of miRNAs by competing for miRNA-binding sites (Salmena et al, 2011;Hansen et al, 2013a;Rong et al, 2017;Dori and Bicciato, 2019;Verduci et al, 2019;Lin et al, 2020;Liang et al, 2020). Secondly, some circRNAs can bind and interact with transcription factors to regulate the transcription of targeted gene (Memczak et al, 2013;Braunschweig et al, 2014).…”