Correlation between Mitochondrial Dysfunction, Cardiovascular Diseases, and Traditional Chinese Medicine

Zhu, Li; Chen, Zhigang; Han, Keli; Zhao, Yilin; Li, Yan; Li, Dongxu; Wang, Xiulong; Xuefang, Li; Sun, Siyu; Lin, Fang; Zhao, Guoan

doi:10.1155/2020/2902136

Cited by 10 publications

(6 citation statements)

References 96 publications

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“…TCM has also been reported to attenuate myocardial ischemia/reperfusion injury by preserving mitochondrial function [ 83 ]. Studies have also shown that TCM can treat cardiovascular disease by protecting mitochondrial function [ 84 ]. Furthermore, metabolic reprogramming in TCM treatment of hypertension has received increasing attention [ 85 ], and metabolic reprogramming by TCM is also important for effective cancer therapy [ 86 ].…”

Section: Discussionmentioning

confidence: 99%

Danggui Buxue Decoction Ameliorates Idiopathic Pulmonary Fibrosis through MicroRNA and Messenger RNA Regulatory Network

Zhang

Wang

Shi

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. To develop a putative microRNA (miRNA) and messenger RNA (mRNA) regulatory network of Danggui Buxue decoction’s (DGBXD) amelioration of idiopathic pulmonary fibrosis (IPF). Methods. The Gene Expression Omnibus (GEO) database was used to identify differentially expressed miRNAs (DE-miRNAs) and differentially expressed mRNAs (DE-mRNAs). Using miRNet, the predicted target genes of identified DE-miRNAs were estimated, and then the target genes of DE-miRNAs in IPF were comprehensively examined. The Enrichr database was used to conduct functional enrichment and pathway enrichment. Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) was employed to obtain the target genes of DGBXD as well as active compounds. A putative miRNA-mRNA regulatory network of DGBXD acting on IPF was developed by intersecting the target genes of DGBXD with the DE-miRNA target genes in IPF. A bleomycin-induced mouse model was established and used to perform histopathology as well as real-time quantitative polymerase chain reaction (qRT-PCR) analyses of some miRNA-mRNA pairs. Results. Fourteen upmodulated DE-miRNAs and six downmodulated DE-miRNAs were screened. The downstream target genes of upmodulated and downmodulated DE-miRNAs were predicted. Subsequently, 1160 upmodulated DE-mRNAs and 1427 downmodulated DE-mRNAs were identified. Then, target genes of DE-miRNAs comprising 49 downmodulated and 53 upmodulated target genes were further screened to perform functional enrichment and pathway enrichment analyses. Subsequently, 196 target genes of DGBXD were obtained from TCMSP, with six downregulated target genes and six upregulated target genes of DGBXD acting on IPF being identified. A promising miRNA-mRNA regulatory network of DGBXD acting on IPF was developed in this study. Moreover, mir-493 together with its target gene Olr1 and mir-338 together with Hif1a were further validated by qRT-PCR. Conclusion. This study proposed detailed possible processes of miRNA-mRNA modulatory axis in IPF and constructed a prospective IPF-related miRNA-mRNA modulatory network with the aim of alleviating IPF with DGBXD.

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Section: Discussionmentioning

confidence: 99%

Danggui Buxue Decoction Ameliorates Idiopathic Pulmonary Fibrosis through MicroRNA and Messenger RNA Regulatory Network

Zhang

Wang

Shi

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…In addition to the mechanisms discussed above, herbal medicine may also impact other cellular processes relevant to NDs. These processes include the modulation of autophagy, enhancement of mitochondrial function and biogenesis, regulation of epigenetic modifications, and modulation of the gut–brain axis through interaction with the gut microbiota (Zhu et al 2020a ; Wang et al 2021b ).…”

Section: Nds and Their Pathogenesismentioning

confidence: 99%

Herbal medicine and gut microbiota: exploring untapped therapeutic potential in neurodegenerative disease management

Guan,

Tang,

et al. 2024

Arch. Pharm. Res.

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The gut microbiota that exists in the human gastrointestinal tract is incredibly important for the maintenance of general health as it contributes to multiple aspects of host physiology. Recent research has revealed a dynamic connection between the gut microbiota and the central nervous system, that can influence neurodegenerative diseases (NDs). Indeed, imbalances in the gut microbiota, or dysbiosis, play a vital role in the pathogenesis and progression of human diseases, particularly NDs. Herbal medicine has been used for centuries to treat human diseases, including NDs. These compounds help to relieve symptoms and delay the progression of NDs by improving intestinal barrier function, reducing neuroinflammation, and modulating neurotransmitter production. Notably, herbal medicine can mitigate the progression of NDs by regulating the gut microbiota. Therefore, an in-depth understanding of the potential mechanisms by which herbal medicine regulates the gut microbiota in the treatment of NDs can help explain the pathogenesis of NDs from a novel perspective and propose novel therapeutic strategies for NDs. In this review, we investigate the potential neuroprotective effects of herbal medicine, focusing on its ability to regulate the gut microbiota and restore homeostasis. We also highlight the challenges and future research priorities of the integration of herbal medicine and modern medicine. As the global population ages, access to this information is becoming increasingly important for developing effective treatments for these diseases.

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“…Many of these functions are impaired by exposure to toxins and diseases. Consequences of mitochondrial dysfunction in the heart include myocardial infarction and ischemia/reperfusion injury, cardiomyopathies, and arrhythmias, and mitochondrial abnormalities have also been described in the pathogenesis of heart failure [ 31 ]. Mitochondrial dysfunction and apoptosis of cardiomyocytes have been observed; these mechanisms likely contribute to the formation of the so-called cirrhotic cardiomyopathy [ 30 , 32 ].…”

Section: The Effect Of Bile Acids On the Cardiovascular Systemmentioning

confidence: 99%

The Role of Bile Acids in the Human Body and in the Development of Diseases

et al. 2022

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Bile acids are specific and quantitatively important organic components of bile, which are synthesized by hepatocytes from cholesterol and are involved in the osmotic process that ensures the outflow of bile. Bile acids include many varieties of amphipathic acid steroids. These are molecules that play a major role in the digestion of fats and the intestinal absorption of hydrophobic compounds and are also involved in the regulation of many functions of the liver, cholangiocytes, and extrahepatic tissues, acting essentially as hormones. The biological effects are realized through variable membrane or nuclear receptors. Hepatic synthesis, intestinal modifications, intestinal peristalsis and permeability, and receptor activity can affect the quantitative and qualitative bile acids composition significantly leading to extrahepatic pathologies. The complexity of bile acids receptors and the effects of cross-activations makes interpretation of the results of the studies rather difficult. In spite, this is a very perspective direction for pharmacology.

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Correlation between Mitochondrial Dysfunction, Cardiovascular Diseases, and Traditional Chinese Medicine

Cited by 10 publications

References 96 publications

Danggui Buxue Decoction Ameliorates Idiopathic Pulmonary Fibrosis through MicroRNA and Messenger RNA Regulatory Network

Danggui Buxue Decoction Ameliorates Idiopathic Pulmonary Fibrosis through MicroRNA and Messenger RNA Regulatory Network

Herbal medicine and gut microbiota: exploring untapped therapeutic potential in neurodegenerative disease management

The Role of Bile Acids in the Human Body and in the Development of Diseases

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