The usefulness of narrow band imaging in the assessment of laryngeal papillomatosis

Abstract

Objectives/HypothesisRecurrent respiratory papillomatosis (RRP) is a benign disease caused by human papillomavirus 6 and 11. The characteristic feature of this disease are wart-like lesions covering the respiratory epithelium with a predilection for the larynx. There is no curative treatment for the disease. The goal of the treatment is a total surgical removal of the papillomatous lesions in order to reduce the number of relapses. Therefore, a good visualization method of papillomas is crucial during surgery. The aim of the study was to compare the accuracy of narrow band imaging (NBI) to the use of white light alone in detecting RRP.MethodsThe study was carried out between April 2013 and November 2015 at Poznan University of Medical Sciences, Department of Otolaryngology, Poland. Rigid endoscopy with conventional white light (WL) and NBI (CV-260SL processor and CLV- 260SL light source, Olympus Optical Co. Ltd, Tokyo, Japan) was performed in all patients during direct laryngoscopy. All anatomical sites of the larynx and trachea were assessed using the Dikkers scale and Derkay total site scoring system with WL and NBI. The consensus was reached as to the number of lesions seen in WL compared to NBI.ResultsDuring 36 microlaryngoscopies, the number of papillomas detected in the larynx (by Derkay total site score) differed significantly between white light endoscopy and NBI (Wilcoxon test p = 0.000655). In endoscopy with NBI, a mean of 1.3 more papillomas in Derkay total site score was detected in comparison to white light endoscopy NBI showed additional areas of diseased tissue in 15/36 (41.67%) patients.ConclusionsNBI as an additional tool during microlaryngoscopy can improve the detection of papillomatous lesions.

Application of haemoglobin absorption spectral imaging in laryngeal papilloma surgery

“…They believe that narrowband imaging can improve the detection rate of laryngeal papilloma. [14][15][16][17][18] However, haemoglobin absorption spectral imaging based on similar imaging principles has not been reported. Therefore, we decided to systematically summarise and compare the microscopical haemoglobin absorption spectral imaging mode and the white light mode in evaluating papilloma lesions.…”

Validation of the European Laryngological Society classification of glottic vascular changes as seen by narrow band imaging in the optical biopsy setting

“…Furthermore, several authors have underlined the utility of NBI for detection of recurrent respiratory papillomatosis and its ability to increase the detection rate of small lesions that invisible by WL alone [29,33,[39][40][41][42]. The excellent performance in terms of CU + Ve and CU−Ve searching for wide angle IPCLs in the identification of respiratory papillomatosis mandates, as previously suggested by the recent literature [33,[39][40][41][42][43][44], the use of biologic endoscopy tools like NBI, and should be considered the endoscopic gold standard for optical biopsy and follow-up of patients affected by laryngeal papillomas.…”

Diagnostic Value of Narrow Band Imaging in Visualization of Pathological Lesions in Larynx and Hypopharynx

“…In our study we found 27 patients with RRP (8.3%), 3 cases were initially suspected from malignancy and proved to be false positive. However, if RRP is suspected other synchronous papillomatous lesions (Jackowska et al 2018) can be detected in NBI. In our study NBI revealed other lesions not visible in WLE in 14/27 (51.8%) (20).…”