“…Moreover, a detailed study is still lacking regarding the applications of this unique class of biosurfactants as possible drug carriers for curcumin under different physiological conditions. CHAPS (3-[(3-cholamidopropyl)-dimethylamino]-1-propanesulfonate), a zwitterionic derivative of cholic acid, having the properties of both the bile acid and the sulfobetaine surfactant, has emerged as one of the most important amphiphiles. − Because of its biocompatibility, neutral nature over a wide pH range, and mildness toward proteins, CHAPS-based colloids could be considered safe and efficacious carriers for drugs and cosmetics. Moreover, zwitterionic-based drug carriers are known to exhibit superior biocompatibility, anti( bio )fouling property, negligible immunogenicity, higher cellular uptake of chemicals and drugs, etc . , Recently, the increasing attention toward the applications of zwitterionic moieties as drug carriers and therapeutics , offers immense opportunity to exploit this bioinspired surfactant in the field of drug delivery; also, a comparison with its bile salt analogues is considered necessary for the fundamental understanding and applications.…”