The Usefulness of an Alternative Diagnostic Method for Sarcopenia Using Thickness and Echo Intensity of Lower Leg Muscles in Older Males

Isaka, M.; Sugimoto, Ken; Yasunobe, Yukiko; Akasaka, Hiroshi; Fujimoto, Taku; Kurinami, Hitomi; Takeya, Yasushi; Yamamoto, Kōichi; Rakugi, Hiromi

doi:10.1016/j.jamda.2019.01.152

Cited by 37 publications

(54 citation statements)

References 37 publications

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“…The current study also clearly showed that the muscle quality was consistently associated with the EI of the lower leg muscles and QFM in older adults (Table 4). Our previous study demonstrated that the ultrasonographic assessment of the lower leg muscles, notably the TA, might be a convenient approach for detecting sarcopenia 42 . Ikezoe et al reported that the MT of the TA, as well as the thigh muscle, significantly decreased in a year in an older Japanese female population 43 .…”

Section: Discussionmentioning

confidence: 94%

The utility of the ultrasonographic assessment of the lower leg muscles to evaluate sarcopenia and muscle quality in older adults

Isaka

Sugimoto

Fujimoto

et al. 2020

JCSM Clinical Reports

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BackgroundThe assessment of muscle quality is expected to help predict the prognosis of sarcopenia and examine the response to intervention. Ultrasonography can be used to evaluate approaches for determining muscle quantity and quality. We focused on the lower leg muscles and examined the relationship between the ultrasonographic assessments and the components of sarcopenia and muscle quality by comparing them with those of the quadriceps muscle (QFM).Methods47 physically healthy older participants aged 78.3 ± 6.0 years (53% male) were enrolled in this cross‐sectional study. Muscle thickness (MT) and echo intensity (EI) of the lower leg muscles and QFM were assessed with ultrasonography. Muscle mass, grip strength, and gait speed, and lower leg muscle strength were measured. Muscle quality was calculated using a formula: leg muscle strength/leg muscle mass.ResultsThe MTs and EIs of the tibialis anterior muscle (TA) and QFM were significantly associated with grip and leg strength. We observed a significant correlation in the MTs and EIs of the lower leg muscles and QFM. The EIs of the lower leg muscles and QFM showed significant negative correlations with muscle quality. In the multiple linear regression model, the EI of the TA and QFM was extracted as an independent factor of muscle quality (TA: β = −0.35, p = 0.0358; QFM: β = −0.30, p = 0.0327).ConclusionsThe ultrasonographic assessments of the lower leg muscles, especially the TA, were associated with sarcopenia components and muscle quality equal to or greater than those of the QFM.

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Section: Discussionmentioning

confidence: 94%

The utility of the ultrasonographic assessment of the lower leg muscles to evaluate sarcopenia and muscle quality in older adults

Isaka

Sugimoto

Fujimoto

et al. 2020

JCSM Clinical Reports

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“…Using a 13-MHz GE Healthcare LOGIQe and a 13-MHz FujiFilm SonoSite M-Turbo probe and diagnostic ultrasonography equipment (Wuxi, China, and Bothell, Washington, USA, respectively), measurements of muscle thickness (MT) and echo intensity of the anterior rectus muscle and vastus medialis muscle will be obtained. 55 A strong correlation between conventional radiological Open access measurements (by MRI or CT) and ultrasound measurements of MT has been previously demonstrated. 56…”

Section: Muscle Ultrasoundmentioning

confidence: 79%

Post-acute sequelae of SARS-CoV-2 infection (PASC): a protocol for a multidisciplinary prospective observational evaluation of a cohort of patients surviving hospitalisation in Sao Paulo, Brazil

et al. 2021

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IntroductionCOVID-19 may lead to persistent and potentially incapacitating clinical manifestations (post-acute sequelae of SARS-CoV-2 infection (PASC)). Using easy-to-apply questionnaires and scales (often by telephone interviewing), several studies evaluated samples of COVID-19 inpatients from 4 weeks to several months after discharge. However, studies conducting systematic multidisciplinary assessments of PASC manifestations are scarce, with thorough in-person objective evaluations restricted to modestly sized subsamples presenting greatest disease severity.Methods and analysesWe will conduct a prospective observational study of surviving individuals (above 18 years of age) from a cohort of over 3000 subjects with laboratory-confirmed COVID-19 who were treated as inpatients at the largest academic health centre in Sao Paulo, Brazil (Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo). All eligible subjects will be consecutively invited to undergo a 1–2-day series of multidisciplinary assessments at 2 time-points, respectively, at 6–9 months and 12–15 months after discharge. Assessment schedules will include detailed multidomain questionnaires applied by medical research staff, self-report scales, objective evaluations of cardiopulmonary functioning, physical functionality and olfactory status, standardised neurological, psychiatric and cognitive examinations, as well as diagnostic laboratory, muscle ultrasound and chest imaging exams. Remaining material from blood tests will be incorporated by a local biobank for use in future investigations on inflammatory markers, genomics, transcriptomics, peptidomics and metabolomics.Ethics and disseminationAll components of this programme have been approved by local research ethics committees. We aim to provide insights into the frequency and severity of chronic/post-COVID multiorgan symptoms, as well as their interrelationships and associations with acute disease features, sociodemographic variables and environmental exposures. Findings will be disseminated in peer-reviewed journals and at scientific meetings. Additionally, we aim to provide a data repository to allow future pathophysiological investigations relating clinical PASC features to biomarker data extracted from blood samples.Trial registration numberRBR-8z7v5wc; Pre-results.

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“…In these instances, it may be more appropriate to perform multiple‐linear regression, with both adipose tissue thickness and echo intensity as independent variables associated with glucose homeostasis. Yet, despite these potential limitations, several publications have observed associations between uncorrected echo intensity and muscle strength, 15,30 function, 16,31 and metabolism, 32 indicating that it may still be a valid metric of muscle composition, but future work exploring its correction is needed to better understand the ideal approaches for its measurement and analysis.…”

Section: Discussionmentioning

confidence: 99%

Influence of Subcutaneous Adipose Tissue and Skeletal Muscle Thickness on Rectus Femoris Echo Intensity in Younger and Older Males and Females

Paris

Bell

Avrutin

et al. 2021

J of Ultrasound Medicine

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Objectives-Ultrasound measurements of muscle echo intensity are commonly used surrogates of muscle composition (eg, intramuscular adipose tissue). However, given that soundwaves are increasingly attenuated with tissue depth, the interpretation of echo intensity may be confounded by adipose and skeletal muscle thickness. Our objectives are to compare the associations between adipose or muscle tissue thickness and rectus femoris echo intensity in younger and older males and females.Methods-Participants included in this analysis were derived from 3 previously published cohorts of younger (<45 years) and older (≥60 years) males and females. Ultrasound images of the rectus femoris were evaluated for muscle thickness, echo intensity, and subcutaneous adipose tissue thickness.Results-Older adults (n: 49 males, 19 females) had a higher body mass index (P = .001) compared with younger adults (n: 37 males, 49 females). Muscle thickness was negatively associated with echo intensity in older males (r = À0.59) and females (r = À0.53), whereas no associations were observed in younger males (r = 0.00) or females (r = À0.11). Subcutaneous adipose tissue thickness displayed no associations with echo intensity in any group.Conclusions-Despite the known influence of subcutaneous adipose tissue thickness on beam attenuation, we observed no association with muscle echo intensity, indicating that adipose tissue correction may be required to better understand muscle echo intensity across differences in adiposity. The negative associations between muscle thickness and echo intensity in older, but not younger adults, suggests these associations may be related to the co-occurrence of skeletal muscle atrophy and intramuscular adipose tissue infiltration with advancing age.

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The Usefulness of an Alternative Diagnostic Method for Sarcopenia Using Thickness and Echo Intensity of Lower Leg Muscles in Older Males

Abstract: JAMDA jo u rn a l h o m e p a g e : w w w. j a m d a. c o m

Cited by 37 publications

References 37 publications

The utility of the ultrasonographic assessment of the lower leg muscles to evaluate sarcopenia and muscle quality in older adults

The utility of the ultrasonographic assessment of the lower leg muscles to evaluate sarcopenia and muscle quality in older adults

Post-acute sequelae of SARS-CoV-2 infection (PASC): a protocol for a multidisciplinary prospective observational evaluation of a cohort of patients surviving hospitalisation in Sao Paulo, Brazil

Influence of Subcutaneous Adipose Tissue and Skeletal Muscle Thickness on Rectus Femoris Echo Intensity in Younger and Older Males and Females

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