The Use of Zoledronic Acid for Solitary Osseous Plasmacytoma in a Dog

Abstract

Summary:A 12-year-old neutered male miniature dachshund was presented with intermittent ataxia. Solitary osseous plasmacytoma (SOP) in the 12th thoracic vertebra (T12) was diagnosed based on the results of diagnostic imaging and histopathology. The combination use of zoledronic acid, melphalan, and prednisolone was extremely effective and long term survival could be achieved, however, mandibular osteonecrosis developed as a suspected adverse effect of zoledronic acid 2 years later. This is the first clinical report of an adverse effect of zoledronic acid in a dog with SOP.