The Use of Xylitol for the Prevention of Xerostomia in Patients Receiving Intensity Modulated Radiation Therapy for Head and Neck Cancers

Maiya, Vikram; Vaid, Neelam; Basu, Sumit; Vatyam, S.; Hegde, Sujai; Deshmukh, Sanjay; Zade, Bhooshan

doi:10.1016/j.ijrobp.2014.05.1700

Cited by 2 publications

(1 citation statement)

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“…On the other hand, in this study's research, we discovered that the risk of xerostomia among individuals with diabetes was decreased by toothpaste containing artificial sweeteners. In a similar previous study, it was discovered that artificial sweeteners such as xylitol can improve salivary flow rates in patients receiving intensity-modulated radiation therapy for head and neck cancers without causing significant side effects [46] and were effective in alleviating the manifestations of dry mouth [47]. Additionally, it was reported that products containing olive oil, betaine, and xylitol that were structured like toothpaste, gel, and spray considerably reduced the majority of symptoms and the constraints on quality of life caused by dry mouth in patients receiving radiation.…”

Section: The Association Between Diabetes Xerostomia Type Of Toothpas...mentioning

confidence: 89%

The Prevalence of Xerostomia in Older Thai Individuals with Type II Diabetes Mellitus and Its Association with Type of Toothpaste and Oral Functions: A Cross-Sectional Study Using Questionnaires

Sonpanao,

Janebodin,

Namvichaisirikul

et al. 2023

Geriatrics

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Aim: To investigate the prevalence of xerostomia in older people with diabetes mellitus and its impacts on oral functions, as well as to determine potential risk factors for xerostomia. Methods: An analytical cross-sectional study was conducted on 623 older type 2 diabetes mellitus (T2DM) Thai people using valid structural questionnaires. Patients were interviewed, and data were recorded. Xerostomia was assessed using subjective symptom questionnaires. Risk factors for xerostomia were analyzed using bivariate and multiple logistic regression analyses. Results: Among the study participants, 38.4% of the older T2DM people had xerostomia, which is associated with sex, age, type of toothpaste, years of diabetes, hemoglobin A1c level, other systemic diseases, medication, smoking, alcohol consumption, and denture wearing. It was significant that xerostomia was associated with toothpaste containing spicy herbal extracts (OR: 9.32 [3.46 to 15.25]), while toothpaste containing artificial sweeteners tended to lower the risk of xerostomia. In addition, older T2DM adults with xerostomia had greater impaired oral functions, which include difficulties in speaking (OR: 3.31 [1.11 to 9.80]), tasting (OR: 5.12 [3.26 to 8.06]), swallowing (OR: 3.59 [2.32 to 5.53]), and chewing (OR: 3.34 [1.15 to 5.82]). Conclusions: Xerostomia is prevalent in older Thai people with T2DM. The results suggest that toothpaste containing spicy herbal extracts might increase the risk of xerostomia, resulting in various oral function problems. Therefore, greater awareness of xerostomia in this group should be raised to monitor dental health, and professionals should work in parallel with other aspects of oral health promotion.

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Section: The Association Between Diabetes Xerostomia Type Of Toothpas...mentioning

confidence: 89%

The Prevalence of Xerostomia in Older Thai Individuals with Type II Diabetes Mellitus and Its Association with Type of Toothpaste and Oral Functions: A Cross-Sectional Study Using Questionnaires

Sonpanao,

Janebodin,

Namvichaisirikul

et al. 2023

Geriatrics

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Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy

Riley

Glenny

Hua

et al. 2017

Cochrane Database of Systematic Reviews

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There is some low-quality evidence to suggest that amifostine prevents the feeling of dry mouth in people receiving radiotherapy to the head and neck (with or without chemotherapy) in the short- (end of radiotherapy) to medium-term (three months postradiotherapy). However, it is less clear whether or not this effect is sustained to 12 months postradiotherapy. The benefits of amifostine should be weighed against its high cost and side effects. There was insufficient evidence to show that any other intervention is beneficial.

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The Use of Xylitol for the Prevention of Xerostomia in Patients Receiving Intensity Modulated Radiation Therapy for Head and Neck Cancers

Cited by 2 publications

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The Prevalence of Xerostomia in Older Thai Individuals with Type II Diabetes Mellitus and Its Association with Type of Toothpaste and Oral Functions: A Cross-Sectional Study Using Questionnaires

The Prevalence of Xerostomia in Older Thai Individuals with Type II Diabetes Mellitus and Its Association with Type of Toothpaste and Oral Functions: A Cross-Sectional Study Using Questionnaires

Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy

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