Abstract:There is some low-quality evidence to suggest that amifostine prevents the feeling of dry mouth in people receiving radiotherapy to the head and neck (with or without chemotherapy) in the short- (end of radiotherapy) to medium-term (three months postradiotherapy). However, it is less clear whether or not this effect is sustained to 12 months postradiotherapy. The benefits of amifostine should be weighed against its high cost and side effects. There was insufficient evidence to show that any other intervention … Show more
“…As medical oxygen is a pharmacological agent when used in the hyperbaric environment, it is hoped that future reviews will rectify this omission to allow meta-analysis inclusion. 5 In conclusion, HBOT may be a safe and effective treatment for LSTRI of the salivary gland and symptoms of xerostomia. It should be considered when available and may prevent the need for dental extractions in the long term for high-risk patients.…”
Section: Discussionmentioning
confidence: 88%
“…A recent Cochrane systematic review on pharmacological interventions for preventing xerostomia did not include HBOT in the search criteria. As medical oxygen is a pharmacological agent when used in the hyperbaric environment, it is hoped that future reviews will rectify this omission to allow meta‐analysis inclusion …”
Section: Discussionmentioning
confidence: 99%
“…Pharmacological therapies are poorly tolerated by patients, and there is little supporting evidence for complementary therapies such as acupuncture or herbal treatments . Amifostine has low‐quality evidence of effectiveness for early radiation‐induced xerostomia, but not late soft tissue radiation injury (LSTRI) . Hence, there is high interest in an effective treatment strategy for these patients.…”
Section: Introductionmentioning
confidence: 99%
“…4 Amifostine has low-quality evidence of effectiveness for early radiation-induced xerostomia, but not late soft tissue radiation injury (LSTRI). 5 Hence, there is high interest in an effective treatment strategy for these patients.…”
Hyperbaric oxygen therapy may be a safe and effective treatment for symptoms of xerostomia after radiation therapy and should be considered when available.
“…As medical oxygen is a pharmacological agent when used in the hyperbaric environment, it is hoped that future reviews will rectify this omission to allow meta-analysis inclusion. 5 In conclusion, HBOT may be a safe and effective treatment for LSTRI of the salivary gland and symptoms of xerostomia. It should be considered when available and may prevent the need for dental extractions in the long term for high-risk patients.…”
Section: Discussionmentioning
confidence: 88%
“…A recent Cochrane systematic review on pharmacological interventions for preventing xerostomia did not include HBOT in the search criteria. As medical oxygen is a pharmacological agent when used in the hyperbaric environment, it is hoped that future reviews will rectify this omission to allow meta‐analysis inclusion …”
Section: Discussionmentioning
confidence: 99%
“…Pharmacological therapies are poorly tolerated by patients, and there is little supporting evidence for complementary therapies such as acupuncture or herbal treatments . Amifostine has low‐quality evidence of effectiveness for early radiation‐induced xerostomia, but not late soft tissue radiation injury (LSTRI) . Hence, there is high interest in an effective treatment strategy for these patients.…”
Section: Introductionmentioning
confidence: 99%
“…4 Amifostine has low-quality evidence of effectiveness for early radiation-induced xerostomia, but not late soft tissue radiation injury (LSTRI). 5 Hence, there is high interest in an effective treatment strategy for these patients.…”
Hyperbaric oxygen therapy may be a safe and effective treatment for symptoms of xerostomia after radiation therapy and should be considered when available.
“…Não há evidência suficiente para se recomendar qualquer outra medida farmacológica como prevenção ao desenvolvimento de xerostomia nos pacientes submetidos a QRT concomitante (131) .…”
Section: Xerostomia E Toxicidade Mucosaunclassified
There is low quality evidence that acupuncture is no different from placebo acupuncture with regard to dry mouth symptoms, which is the most important outcome. This may be because there were insufficient participants included in the two trials to show a possible effect or it may be that there was some benefit due to 'placebo' acupuncture which could have biased the effect to the null. There is insufficient evidence to determine the effects of electrostimulation devices on dry mouth symptoms. It is well known that dry mouth symptoms may be problematic even when saliva production is increased, yet only two of the trials that evaluated acupuncture reported dry mouth symptoms, a worrying reporting bias. There is some low quality evidence that acupuncture results in a small increase in saliva production in patients with dry mouth following radiotherapy.There is insufficient evidence to determine the effects of electrostimulation devices on dry mouth symptoms or saliva production in patients with Sjögren's Syndrome. Reported adverse effects of acupuncture are mild and of short duration, and there were no reported adverse effects from electrostimulation.
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