The Use of V.A.C. VERAFLO CLEANSE CHOICE in the Burn Population

Matthews, Marc R.; Hechtman, Aaron; Quan, Asia N; Foster, Kevin N; Fernandez, Luis

doi:10.7759/cureus.3632

Cited by 7 publications

(6 citation statements)

References 7 publications

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“…In a series of case reports, opting for a VERAFLO cleanse combined with instillation therapy resulted in faster closure of the wound in the burn or necrotizing soft tissue infection patient populations. 42 Another study demonstrated that the combination of NPWTi-d with this reticulated open-cell foam dressing helps the formation of granulation tissue and could potentially represent a cost-effective way of reducing surgical debridement. 43 Closed Incision Negative-Pressure Therapy NPWT can also be applied to a primary closed surgical wound to improve its healing and reduce its vulnerability to complications.…”

Section: Cleanse Choice 40mentioning

confidence: 99%

Negative Pressure Wound Therapy: Mechanism of Action and Clinical Applications

et al. 2021

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Negative pressure wound therapy (NPWT) promotes healing by evenly applying negative pressure on the surface of the wound. The system consists of a sponge, a semiocclusive barrier, and a fluid collection system. Its effectiveness is explained by four main mechanisms of action, including macrodeformation of the tissues, drainage of extracellular inflammatory fluids, stabilization of the environment of the wound, and microdeformation. Rarely will complications linked to NPWT occur, but special care must be taken to prevent events such as toxic shock syndrome, fistulization, bleeding, and pain. New NPWT modalities have been recently developed to make NPWT suitable for a wider variety of wounds. These include NPWT with instillation therapy (NPWTi-d), different cleansing options, and application of NPWT on primarily closed incisions. Finally, vacuum-assisted wound closure therapy has been demonstrated to be efficient for various clinical settings, such as the management of diabetic foot ulcers, pressure ulcerations, chronic wounds, and skin grafts.

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Section: Cleanse Choice 40mentioning

confidence: 99%

Negative Pressure Wound Therapy: Mechanism of Action and Clinical Applications

et al. 2021

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“…Further, with a pH of 5.5, applications are gentle and well tolerated 27 . It can be delivered as a soak, wound packing, and in combination with NPWT as an instill-dwell solution to treat a variety of wounds and burns 29,30 . In addition, HOCl solution is effective in treating various species of Candida and bacteria, including Bacillus anthracis , Clostridium difficile , methicillin-resistant Staphylococcus aureus , P aeruginosa , and E coli biofilms 25,31,32 .…”

Section: Discussionmentioning

confidence: 99%

Healing Exposed Calvarial Hardware Using Negative-Pressure Wound Therapy and Vashe Wound Solution: Case Report

Ockerman

Cox

Wiesemann

et al. 2023

Adv Skin Wound Care

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OBJECTIVE:The management of cranioplasty infections has historically been explantation followed by delayed reimplantation/reconstruction. This treatment algorithm necessitates surgery, tissue expansion, and prolonged disfigurement. In this report, the authors describe a treatment approach consisting of serial vacuum-assisted closure (VAC) with hypochlorous acid (HOCl) solution (Vashe Wound Solution; URGO Medical) as a salvage strategy. METHODS:A 35-year-old man who sustained head trauma, neurosurgical complications, and severe syndrome of the trephined (SOT; devastating neurologic decline treated by cranioplasty) underwent titanium cranioplasty with free flap. Three weeks postoperation, he presented with pressure-related wound dehiscence/partial flap necrosis, exposed hardware, and bacterial infection. Given the severity of his precranioplasty SOT, hardware salvage was critical. He was treated with serial VAC with HOCl solution for 11 days followed by VAC for 18 days and definitive split-thickness skin graft placement over resulting granulation tissue. Authors also conducted a literature review of cranial reconstruction infection management. RESULTS:The patient remained healed 7 months postoperatively without recurrent infection. Importantly, his original hardware was retained, and his SOT remained resolved. Findings from the literature review support the use of conservative modalities to salvage cranial reconstructions without hardware removal. CONCLUSIONS:This study investigates a new strategy for managing cranioplasty infections. The VAC with HOCl solution regimen was effective in treating the infection and salvaging the cranioplasty, thus obviating the complications associated with explantation, new cranioplasty, and recurrence of SOT. There is limited literature on the management of cranioplasty infections using conservative treatments. A larger study to better determine the efficacy of VAC with HOCl solution is underway.

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“…VERAFLO CLEANSE CHOICE), a new device of NPWT, is a reticulated open cell foam dressing that was designed for the instillation of a solution in order to lavage the wound bed. 15 NPWT with instillation of antimicrobials achieved significant reductions in S. aureus biofilm thickness and mass in vitro. 16 Previous experiment in pigs indicated that NPWT with delivery of active antimicrobial agents enhanced the reduction of CFUs by increasing destruction and removal of biofilm bacteria.…”

Section: Introductionmentioning

confidence: 92%

“…For example, VVCC (V.A.C. VERAFLO CLEANSE CHOICE), a new device of NPWT, is a reticulated open cell foam dressing that was designed for the instillation of a solution in order to lavage the wound bed 15 . NPWT with instillation of antimicrobials achieved significant reductions in S. aureus biofilm thickness and mass in vitro 16 .…”

Section: Introductionmentioning

confidence: 99%

Clinical outcomes of negative pressure wound therapy with instillation vs standard negative pressure wound therapy for wounds: A meta‐analysis of randomised controlled trials

Wang

et al. 2022

International Wound Journal

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Negative pressure wound therapy (NPWT) with or without instillation has been extensively applied for patients with multiple wound types. Whether NPWT with instillation is superior to NPWT alone is not known. This study aims to compare the efficacy between negative pressure wound therapy with instillation (NPWTi) and standard negative pressure wound therapy for wounds. The authors searched for randomised controlled trials (RCTs) in PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials investigating clinical outcomes of negative pressure wound therapy with instillation vs standard negative pressure wound therapy for wounds. The registration number (protocol) on PROSPERO is CRD42022287178. Eight RCTs involved 564 patients met the inclusion criteria and were included finally. NPWTi showed a significant fewer surgeries and dressing changes (RR and 95% CI, −9.31 [−17.54, −1.08], P < 0.05), and smaller wound area after treatment (RR and 95% CI, −9.31 [−17.54, −1.08], P < 0.05) compared with NPWT. No significant difference was observed on healing rate, time to heal, length of stay, dehiscence, reinfection, reoperation and readmission between NPWTi and NPWT. The addition of instillation to NPWT could improve clinical outcomes regarding the number of surgeries and dressing changes, and wound area after treatment in patients with multiple wound types. However, because of the heterogeneity these conclusions still need to be further validated by more well‐designed RCTs with large sample sizes.

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The Use of V.A.C. VERAFLO CLEANSE CHOICE in the Burn Population

Cited by 7 publications

References 7 publications

Negative Pressure Wound Therapy: Mechanism of Action and Clinical Applications

Negative Pressure Wound Therapy: Mechanism of Action and Clinical Applications

Healing Exposed Calvarial Hardware Using Negative-Pressure Wound Therapy and Vashe Wound Solution: Case Report

Clinical outcomes of negative pressure wound therapy with instillation vs standard negative pressure wound therapy for wounds: A meta‐analysis of randomised controlled trials

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