The Use of Two-Dimensional Strain Measured by Speckle Tracking in the Identification of Incipient Ventricular Dysfunction in HIV-Infected Patients on Antiretroviral Therapy, Untreated HIV Patients and Healthy Controls

Rodrigues, Ronaldo Campos; Azevedo, Kátia Martins Lopes de; Moscavitch, Samuel Datum; Setúbal, Sérgio; Mesquita, Cláudio Tinoco

doi:10.5935/abc.20190169

Cited by 8 publications

(14 citation statements)

References 42 publications

(37 reference statements)

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“…and Rodrigues et al4 reported that HIV T A B L E 1 Characteristics and laboratory variables of the patients had lower LV GLS than controls, regardless of the type of ART. Rodrigues et al 4 also compared LV GLS according to the ART regimens and found that there were no difference in LV GLS among the groups.…”

mentioning

confidence: 92%

“…It is associated with poor prognosis. The initiation of ART has dramatically changed the clinical manifestation of HIV infection, especially in high‐income countries, from severe LV systolic dysfunction to a pattern of subclinical cardiac dysfunction characterized by abnormal diastolic function and deformation 4,5 . Thus, a need for detecting apparently healthy but risky subjects for future cardiac events has emerged.…”

Section: Introductionmentioning

confidence: 99%

“…2D‐STE derived strain indices are known to be less likely preload or afterload dependent and more sensitive to identify subtle changes in myocardial functions than conventional echocardiographic indices 8,9 . Current data provide limited evidence about the relation between HIV infection and these indices 4,10,11 . There is also limited information about the effects of different ART combinations on cardiac functions.…”

Section: Introductionmentioning

confidence: 99%

“…The initiation of ART has dramatically changed the clinical manifestation of HIV infection, especially in high-income countries, from severe LV systolic dysfunction to a pattern of subclinical cardiac dysfunction characterized by abnormal diastolic function and deformation. 4,5 Thus, a need for detecting apparently healthy but risky subjects for future cardiac events has emerged. Two-dimensional speckle tracking echocardiography (2D-STE) derived strain measurements have been used in many diseases to prove either clinically evident or subclinical cardiac involvement.…”

mentioning

confidence: 99%

“…8,9 Current data provide limited evidence about the relation between HIV infection and these indices. 4,10,11 There is also limited information about the effects of different ART combinations on cardiac functions.…”

mentioning

confidence: 99%

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Ventricular and atrial functions assessed by speckle‐tracking echocardiography in patients with human immunodeficiency virus

Çinçin

Özben

Tigen

et al. 2020

J of Clinical Ultrasound

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Purpose: Antiretroviral therapy (ART) has dramatically changed the clinical manifestation of human immunodeficiency virus (HIV) associated cardiomyopathy from severe left ventricular (LV) systolic dysfunction to a pattern of subclinical cardiac dysfunction. The aim of this study was to evaluate by speckle tracking echocardiography (STE) LV, right ventricular (RV), and biatrial functions in HIV-infected patients under different ART combinations. Methods: We consecutively included 128 HIV-infected patients (mean age 44.2 ± 10.1 years, 110 males) and 100 controls (mean age 42.1 ± 9.4 years, 83 males).Ventricular and atrial functions were assessed by both conventional and STE.Results: Although there was not any significant difference in conventional echocardiographic variables, HIV-infected patients had significantly lower LV global longitudinal strain (GLS), RV GLS, left atrial (LA) reservoir and conduit strain, and right atrial conduit strain. HIV patients receiving integrase strand transfer inhibitors and protease inhibitors (PI) had significantly lower LV GLS and LA conduit strain, while patients receiving non-nucleoside reverse transcriptase inhibitors and PI had significantly lower RV GLS than controls. CD4 count at the time of echocardiography was strongly correlated with LV GLS (r = .619, P < .001) and RV GLS (r = .606, P < .001). Conclusion:Biventricular and atrial functions are subclinically impaired in HIVinfected patients. ART regimen may also affect myocardial functions.

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confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Ventricular and atrial functions assessed by speckle‐tracking echocardiography in patients with human immunodeficiency virus

Çinçin

Özben

Tigen

et al. 2020

J of Clinical Ultrasound

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Echocardiography in Patients with HIV Infection

Sud

Argulian

2020

Curr Cardiol Rep

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Coronary Vasculature and Myocardial Structure in HIV: Physiologic Insights From the Renin-Angiotensin-Aldosterone System

Srinivasa

Thomas

Feldpausch

et al. 2021

The Journal of Clinical Endocrinology &Amp; Metabolism

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The landscape of HIV medicine dramatically changed with the advent of contemporary antiretroviral therapies (ART) which has allowed persons with HIV (PWH) to achieve good virologic control, essentially eliminating HIV-related complications and increasing life expectancy. As PWH are living longer, non-communicable diseases, such as cardiovascular disease (CVD), have become a leading cause of morbidity and mortality in PWH with rates that are 50-100% higher than in well-matched persons without HIV. In this review, we focus on disease of the coronary microvasculature and myocardium in HIV. We highlight a key hormonal system important to cardiovascular endocrinology, the renin-angiotensin-aldosterone system (RAAS), as a potential mediator of inflammatory driven-vascular and myocardial injury and consider RAAS blockade as a physiologically-targeted strategy to reduce CVD in HIV.

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The Use of Two-Dimensional Strain Measured by Speckle Tracking in the Identification of Incipient Ventricular Dysfunction in HIV-Infected Patients on Antiretroviral Therapy, Untreated HIV Patients and Healthy Controls

Cited by 8 publications

References 42 publications

Ventricular and atrial functions assessed by speckle‐tracking echocardiography in patients with human immunodeficiency virus

Ventricular and atrial functions assessed by speckle‐tracking echocardiography in patients with human immunodeficiency virus

Echocardiography in Patients with HIV Infection

Coronary Vasculature and Myocardial Structure in HIV: Physiologic Insights From the Renin-Angiotensin-Aldosterone System

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