The use of triple quadrupoles for sequential mass spectrometry: 1—The instrument parameters

Dawson, Peter; French, John B.; Buckley, James A.; Douglas, D. J.; Simmons, Daniel

doi:10.1002/oms.1210170503

Cited by 145 publications

(58 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This concordance establishes 1) that our instrument is kinetically well behaved, and 2) the validity of Dawson's design considerations (closely-coupled quadrupole fields, properly filled acceptance, etc.) [3][4][5][6][7]. Similar agreement between Ln Y and Ln W measure- …”

Section: Discussionmentioning

confidence: 64%

“…Letters of inquiry from prospective participants may be sent to NBS. [50] demonstrated that computer simulation of breakdown curves is plausible. Hence, one can envision a CAD spectral database of critically-evaluated cross sections U;j. Ui/(, etc.…”

Section: Discussionmentioning

confidence: 99%

“…7 to conform to the design considerations stipulated by Dawson and coworkers [3][4][5][6][7]. It consists of three standard 7-270-9 quadrupole rod assemblies (Ql, Q2, Q3) mounted in tandem on a special multipurpose track.…”

Section: Methodsmentioning

confidence: 99%

“…Abundant experimental and theoretical results had been previously reported for this reaction. Furthermore, because the NBS instrument had been constructed to incorporate the design considerations detailed by Dawson and coworkers [3][4][5][6][7], eq (4) [6] could be used to estimate Leff=R Lactual' (4) Here Lactual is the actual rectilinear pathlength for a well-confined CAD gas target; M = mass of projectile ion (in amu), E =axial ion energy (in eV), ro=field radius (in cm), F=rf frequency (in MHz). Equation (4) is based on operation of Q2 with the Mathieu parameters [3,4] at a2=O, Q2=O.28 [6].5 It was shown [8] that when the effective target thickness was estimated by using eq (4), values for the absolute reaction cross section derived from eq [2] were in excellent agreement with theoretical predictions, as well as with previous experimentallydetermined values.…”

Section: Kinetic !\Iethodmentioning

confidence: 99%

See 3 more Smart Citations

Instrument-independent cad spectral databases: absolute cross-section measurements in QQQ instruments

Martinez¹,

Dheandhanoo²

1987

J. RES. NATL. BUR. STAN.

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Kinetic !\Iethodmentioning

confidence: 99%

See 2 more Smart Citations

Instrument-independent cad spectral databases: absolute cross-section measurements in QQQ instruments

Martinez¹,

Dheandhanoo²

1987

J. RES. NATL. BUR. STAN.

View full text Add to dashboard Cite

show abstract

“…Low energy CID was carried out in the second quadrupole with argon as the collision gas at a typical thickness [27,28] of approximately 2.0 × 1014 atoms cm 2 for the TAGA, and with nitrogen at a thickness of approximately 20 × 1014 molecules cm -2 for the API 300. The collision energy at the laboratory frame of reference (Ela b) was typically approximately 40-80 eV.…”

Section: Methodsmentioning

confidence: 99%

Complexes of silver(I) with peptides and proteins as produced in electrospray mass spectrometry

Siu

Guevremont

et al. 1997

J. Am. Soc. Mass Spectrom.

View full text Add to dashboard Cite

Silver(I) forms aqueous phase complexes with both sulfur and nonsulfur containing peptides and proteins. These complexes were introduced into the gas phase via electrospray, and their structures probed by means of tandem mass spectrometry. Experiments with di-, tri-, and oligopeptides show that the abundance of silver(I)-containing ions increases relative to that of proton-containing ions as peptide length increases. This increase is much more dramatic for methionine-containing peptides. Collision-induced dissociation of silver-peptide complexes yields a multitude of product ions that are silver containing. However, even for methioninecontaining peptides, very few of these product ions contain the methionine residue. The solution-phase structure and the gas-phase structure of the silver/peptide complex are not identical. The methionine sulfur acts as the silver anchoring point in solution. Desolvation in the gas phase leads to a rearrangement of the silver/peptide complex such that the silver ion becomes chelated to the nitrogen and oxygen atom on the peptide backbone in addition to the methionine sulfur. This rearrangement decreases the importance of the silver/sulfur bond to the extent that it is frequently broken upon collision activation and leads to the formation of silver/peptide product ions that are nonsulfur bearing. (J Am Soc Mass Spectrom 1997, 8, 781-792) Crown copyright 1997 M ass spectrometric investigations of metal-ion binding to peptides and proteins in the gas phase are frequently prompted by the desire to compare the same binding in solution . Aside from its sensitivity and selectivity, mass spectrometry, because it measures the properties of an analyte in vacuum, offers a view of the intrinsic metal binding properties of proteins, unencumbered with solvation. A number of groups have devoted much time and effort on complexes of alkali [1-10], alkaline-earth [8,[11][12][13][14], and transition metals [15][16][17][18][19][20][21]. While most of these investigations centered on cationic metal complexes [1-6, 8, 9, 16-21], some involved anionic complexes as well [7,[10][11][12][13][14][15]. In earlier studies, fast atom bombardment (FAB) was the sample-introduction technique of choice due to its ease of producing a significant population of metal ions within the source. In later studies, the choice was between FAB and electrospray, the latter of the two, of course, offers the added convenience and [9,10,14,[16][17][18][19].The silver(I) ion is considered a "soft" cation according to Pearson's classification, and as such it prefers binding to soft ligands, ligands that are relatively polarizable [22]. Of all the functional groups of a protein, the softest groups are the sulfur ligand on the side-chain of cysteine and that of methionine [23]. Because the number and location of sulfur-containing residues are often desired information in the determination of unknown peptides, any specific metal binding to these sulfur ligands is potentially analytically useful with the metal ions serving as flags o...

show abstract

Use of ion-molecule reactions for selected reaction monitoring in gas chromatographic/tandem mass spectrometric analyses in two model systems

Kinter

Bursey

1988

Biol. Mass Spectrom.

View full text Add to dashboard Cite

The use of ion-molecule reactions with NH3 for selected reaction monitoring (SRM) in gas chromatographic/tandem mass spectrometric analysis is demonstrated for 2-methoxyethanol and chlorobenzene in methanol and urine. In the former, the reaction [CH3OC2H4]+ + NH3----[H2NC2H4]+ + CH3OH was followed; in the latter, the reaction [-C3H5Cl]+. + NH3----[C6H5NH3]+ + Cl.. Increased selectivity and an improvement in sensitivity by factors of up to five were observed when compared to conventional SRM analyses that used collisionally activated decompositions on NH3. SRM analyses with a triple quadrupole tandem mass spectrometer using ion-molecule reactions rather than collisionally activated decompositions have been found to be more sensitive and more selective in two model systems.

show abstract

The use of triple quadrupoles for sequential mass spectrometry: 1—The instrument parameters

Cited by 145 publications

References 12 publications

Instrument-independent cad spectral databases: absolute cross-section measurements in QQQ instruments

Instrument-independent cad spectral databases: absolute cross-section measurements in QQQ instruments

Complexes of silver(I) with peptides and proteins as produced in electrospray mass spectrometry

Use of ion-molecule reactions for selected reaction monitoring in gas chromatographic/tandem mass spectrometric analyses in two model systems

Contact Info

Product

Resources

About