The use of tolmetin sodium in systemic onset juvenile rheumatoid arthritis

Gewanter, Harry L.; Baum, John

doi:10.1002/art.1780241013

Cited by 8 publications

(2 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has also been reported to be of value in the management of systemic onset juvenile arthritis (Gewanter & Baum 1981). The recommended dosage is tolmetin 15 to 30 mg/kg/day in 3 divided doses (Silver 1988), but pharmacokinetic studies in juvenile arthritis patients have not been published.…”

Section: Tolmetinmentioning

confidence: 98%

Clinical Pharmacokinetics of Drugs Used in Juvenile Arthritis

Skeith

Jamali

1991

Clinical Pharmacokinetics

View full text Add to dashboard Cite

Juvenile arthritis is defined as the occurrence of objective evidence of arthritis for a minimum of 6 weeks, in a child 16 years of age or younger. With a reported incidence of 9 to 19.6 per 100,000 children, juvenile arthritis is considered to be a rare disease. There is no known cure; however, up to 75% of patients will undergo remission by late adolescence. Drugs used in the treatment of juvenile arthritis are divided into 2 major classes: (a) the nonsteroidal anti-inflammatory drugs (NSAIDs) including salicylates, naproxen, ibuprofen, fenoprofen, ketoprofen, flurbiprofen, indomethacin, sulindac, tolmetin and diclofenac, and (b) disease modifying agents which encompass drugs such as antimalarial agents, gold, methotrexate, penicillamine and sulfasalazine. In almost all the reports dealing with the pharmacokinetics of NSAIDs, the level of disease activity has not been noted. The level of activity is important since, during a flare, the plasma albumin may fall to the point that it causes a substantial and clinically significant increase in the unbound serum concentration of highly bound drugs. The relationship between the concentration of these drugs in the systemic circulation and their efficacy is not clear. However, for many of them, therapeutic drug monitoring is recommended as a means of reducing the possibility of toxic reactions. Further pharmacokinetic and -dynamic evaluations are needed for many of these drugs in juvenile arthritis.

show abstract

Section: Tolmetinmentioning

confidence: 98%

Clinical Pharmacokinetics of Drugs Used in Juvenile Arthritis

Skeith

Jamali

1991

Clinical Pharmacokinetics

View full text Add to dashboard Cite

show abstract

“…Of the non‐steroidal anti‐inflammatory drugs currently available, ibuprofen, in dosages up to 60 mg/kilo body weight per 24 hours would appear to modify the fever chart, but again liver function should be watched. Tolmetin appears to be useful in controlling fever similarly naproxen has been reported to be effective 22 …”

Section: Managementmentioning

confidence: 99%

Still's Disease

Ansell¹

1991

Int J Clinical Practice

View full text Add to dashboard Cite

George Frederic Still (1868‐1941) was one of 12 children, three of whom died in their first year of life and two later in childhood. He was brought up in Highbury, London. He obtained a scholarship to Merchant Taylor's School and then a further scholarship to Caius College, Cambridge, where he achieved a first class honours in the Classical Tripos. He studied medicine at Guy's Hospital, London, qualifying in 1893. His first appointment was as a house physician at Guy's. He then went to the Hospital for Sick Children, Great Ormond Street, London, firstly as a house physician and then as a medical registrar and pathologist. It was from here that, in November 1896, Dr Archibald Garrod read Still's classic paper entitled ‘On a form of chronic joint disease in children’ to the Royal Medical and Chirurgical Society. The paper was published in their transactions the following year1 and was also the subject of Still's Cambridge MD thesis.

show abstract

Nonsteroidal Anti‐Inflammatory Drugs in the Management of Juvenile Arthritis

Silver

1988

The Journal of Clinical Pharma

View full text Add to dashboard Cite

The use of tolmetin sodium in systemic onset juvenile rheumatoid arthritis

Cited by 8 publications

References 9 publications

Clinical Pharmacokinetics of Drugs Used in Juvenile Arthritis

Clinical Pharmacokinetics of Drugs Used in Juvenile Arthritis

Still's Disease

Nonsteroidal Anti‐Inflammatory Drugs in the Management of Juvenile Arthritis

Contact Info

Product

Resources

About