The use of the plasma epinephrine response in the diagnosis of idiopathic postprandial syndrome

Hypoglycemic symptoms in the absence of diabetes: Pilot evidence of clinical hypoglycemia in young women

“…Other conditions that might explain our findings are also similarly rare, especially in young adult women. A stronger possibility is that symptoms are associated with epinephrine release triggered by low glucose [1], [20]. While it was not possible to measure epinephrine in this pilot study, this hypothesis would provide explanation for delays between hypoglycemia and symptom occurrence as glucose would already have started to rise by the time individuals felt the effects of epinephrine.…”

“…Firstly, to our knowledge this is the first study to use the new CGM technology to investigate the concordance of hypoglycemic symptoms with low glucose in individuals without diabetes. Without the use of CGM, studies on this topic have primarily been relegated to short observations in the laboratory setting [1], [25], [26], [27], [28], [29], [30], [31], [32], where it has been challenging to capture symptoms. Additionally, the use of blinded CGM ensured that normal daily behavior and symptoms reporting was not influenced by glucose readings.…”

“…Hypoglycemia in the absence of diabetes, sometimes referred to as reactive, postprandial, or idiopathic hypoglycemia [1], is a regular complaint by young non-diabetic patients referred for endocrinology evaluation. Despite this prevalent medical concern and the estimate that 38% of women in the UK may experience this condition [2], there are currently no standard diagnostic criteria for this syndrome [3], few estimates of its prevalence in the general population, and little evidence about its potential health implications.…”

Hypoglycemic Disorders

“…36 Efforts to classify such patients according to differences in their counterregulatory hormone response to the oral administration of glucose have been unsuccessful. [37][38][39] There are no bona fide hypoglycemic disorders characterized solely by autonomic symptoms. Although some episodes of illness in persons with true hypoglycemic disorders may be sufficiently mild to generate only this type of symptom, eventually episodes of neuroglycopenia will also occur.…”