The Use of Testosterone Propionate in Functional Bleeding

Geist, Samuel H.; Salmon, Udall J.; Gaines, Joseph A.

doi:10.1210/endo-23-6-784

Cited by 22 publications

(5 citation statements)

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“…The histological changes found in the present series after administration of testosterone are the same as those described for the human subject by Geist et al [1938], who suggest that the regressive changes are the 'end results of a primary inhibition of the gonadotrophic factors of the hypo¬ physis ' with consequent failure of secretion of the ovarian hormones ; in the light of the present work on the monkey the endometrial changes may be due either to a direct action of testosterone or to its neutralization of the oestrone-in the intact animal these effects may be reinforced by pituitary inhibition. Loeser [1938] reported endometrial atrophy in a woman after testosterone therapy; Foss [1938] said that in his cases after testosterone the endometrium was of the interval type.…”

Section: Resultssupporting

confidence: 84%

“…These considerations led to the adoption of an average dose of about 1 mg. of oestrone in oil per day ; this amount should give a good contrast with the spayed untreated group. The dosage of testosterone propionate was of the same order as that given by Geist, Salmon & Gaines [1938] to women-again a large dose should produce a change if one was forthcoming. The dosage of progesterone varied over a range, on a weight basis, from about the same as that given to women threatened with abortion to a very much greater dosage.…”

Section: Resultsmentioning

confidence: 99%

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The Behaviour of the Uterus of the Rhesus Monkey Under the Influence of Certain Hormones

Bell¹

1942

Journal of Endocrinology

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In view of the well-known species differences in the realm of reproductive physiology it would be a great advantage if an animal were found whose uterine muscle reacted in a manner similar to that of the human subject. It would make investigations of dosage of hormones and of hormone therapy of uterine muscle distinctly easier.The fifteen animals, all of the species Macaca mulatta, were healthy but probably subadult, except Mil, which had the wrinkled sex skin of the adult, and M 3 which showed an ovulating follicle at operation although the sex skin was not wrinkled ; M 3 and Mil were the heaviest animals in the series. It is not possible to give an estimate of the age of any of the animals, but, as will be seen later, there is in the experiments no char¬ acteristic of the behaviour of the uterus which can be correlated with the body weight (as an index of the age) of the animals.All the animals were ovariectomized through a mid-line ventral incision using aseptic precautions. Nembutal (30 mg./kg.) given subcutaneously in about 5 ml. of Locke's solution was found to be an ideal anaesthetic. Only a little ether by inhalation was necessary when going through the peri¬ toneum. The abdomen was closed carefully, layer by layer, and the skin wound covered by collodion gauze. In order to prolong the period of post¬ operative quiescence a further dose of nembutal was given when the animal

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Section: Resultssupporting

confidence: 84%

Section: Resultsmentioning

confidence: 99%

The Behaviour of the Uterus of the Rhesus Monkey Under the Influence of Certain Hormones

Bell¹

1942

Journal of Endocrinology

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“…However, it has more recently been found that doses below the gonadotropin suppressing range are still very adequate for contraception. The effect of these compounds may therefore be on the reproductive organs rather than on the pituitary, as previously supposed.1 9 It should be noted that the administration of minimum ovulation suppressing doses is frequently complicated by breakthrough bleeding, which in turn can be prevented by the addition of small doses of estrogens. Upon the discontinuance of therapy, ovulation usually resumes promptly.…”

Section: Contraceptionmentioning

confidence: 92%

“…10 An alternative procedure involves the injection of progesterone in oil combined with testosterone, 25 mg. of each, the two being given daily over a period of 5 days.1. 9,14 The testosterone is supposed to exert a uterine hemostatic effect, but has little influence on PROGESTERONE ETHISTERONE PRANON£ LUTOCYLOL the structure of the endometrium. The progesterone preparation of choice is that dissolved in oil rather than in aqueous solution.…”

Section: Uses In Menstrual Abnormalitiesmentioning

confidence: 99%

The therapeutic use of progestational steroids

Berczeller¹,

Young²,

Kupperman³

1964

Clin Pharma and Therapeutics

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Although the progestins in common play an integral role in the endogenous synthesis of all steroids, precise definition of what a progestin is is nonetheless difficult, since the progestational steroids are ubiquitous steroids of multiple sources in the body and have many different effects and facets of action. The gonadal and metabolic effects of the progestins are discussed in detail. Uses in menstrual abnormalities, contraception, cancer, endometriosis, and habitual abortion are considered from the therapeutic point of view.

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“…I N THE PAST THREE YEARS testosterone propionate has been used extensively in the treatment of functional gynecologic conditions (1)(2)(3)(4)(5)(6)(7)(8)(9). This paper is a report of 10 cases of functional meno-metrorrhagia, treated with synthetic androgen (testosterone propionate), in which the therapeutic results were evidence of the usefulness of the male hormone in functional bleeding.…”

mentioning

confidence: 99%

Use of Testosterone Propionate in Functional Bleeding

Leff

1941

The Journal of Clinical Endocrinology & Metabolism

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I N THE PAST THREE YEARS testosterone propionate has been used extensively in the treatment of functional gynecologic conditions (1-9). This paper is a report of 10 cases of functional meno-metrorrhagia, treated with synthetic androgen (testosterone propionate), in which the therapeutic results were evidence of the usefulness of the male hormone in functional bleeding.The rationale of this form of therapy and its margins of safety have been discussed at length elsewhere (10-13). Several investigators (14-18) have shown the bisexual action of the androgens in the female rabbit and spayed rats, manifest by estrogenic and progesta' tional activity of the endometrium. (This does not occur in monkeys or human subjects.) Salmon (19) has shown that not only do androgens exercise a direct stimulating effect on the Mullerian tract of rats but they also produce follicle growth and corpora lutea in the ovaries of immature rats. This gonadotropic effect is mediated through the hypophysis The biological properties of the male hormone in women have been studied by many investigators. It has been shown that testosterone propionate inhibits the gonadotropic hyperactivity of the hypophysis of a castrate woman (3), suppresses menstruation (4), produces atrophy of the endometrium (21), deficiency changes in the vaginal smear (4) with disappearance of the glycogen (12), and inhibits peristalsis of the fallopian tubes (23).Dosage. During this entire investigation an effort was made to achieve therapeutic results with as small a dose as possible. Some investigators used as much as 1000 mg. per month, and others reported results with as little as 30 to 75 mg. per month. We tried to strike a balance and used dosages varying from 45 mg. to 325 mg. per month. These dosages were administered in 10, 25 and 50 mg. injections of testosterone propionate (intramuscularly and subcutaneously) in sesame oil.Received for publication February 17, 1941. CASE REPORTSCase 1. H.B. age 22, complained of meno-metrorrhagia for a period of 18 months, following a spontaneous abortion. The first month we observed her she bled every day, using 6 to 8 pads daily. Pelvic examination revealed lacerated cervix and second degree retroversion of the uterus. Preliminary endometrial biopsy, during a bleeding phase showed an early proliferative stage. She was given 75 mg. of testosterone propionate in the next week, after which she noticed a definite diminution in the profuseness of the flow. The next month (now only bleeding very slightly) she received 2,65 mg. of testosterone propionate, and bleeding ceased at the end of the third week. Endometrial biopsy on the 19th day of cycle again showed an early inactive type of estrogenic pattern. The vaginal smears during this course of treatment all showed good estrogenic effect. (The psychological effect upon this patient was extraordinary, her personality reflected a new interest in life.) The third month she received 300 mg. of testosterone propionate and had only 3 days of actual bleeding with a few days of spotting. Bio...

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The Use of Testosterone Propionate in Functional Bleeding

Cited by 22 publications

References 0 publications

The Behaviour of the Uterus of the Rhesus Monkey Under the Influence of Certain Hormones

The Behaviour of the Uterus of the Rhesus Monkey Under the Influence of Certain Hormones

The therapeutic use of progestational steroids

Use of Testosterone Propionate in Functional Bleeding

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