non-small cell lung carcinoma (NSCLC) may be challenging. 8,9 The latter shows striking pleomorphism in contrast to the monotonous appearance of SMARCA4-DTS, is frequently positive for Hepar-1 and cytokeratin-7, and usually shows some degree of glandular differentiation which is always absent in SMARCA4-DTS. 8 Nevertheless, SMARCA4-DTS and SMARCA4-deficient NSCLC show considerable overlap in their clinicopathological profiles: male preponderance, association with smoking, pattern of metastases, poor clinical outcomes, histomorphology, immunoprofile, and molecular alterations such as concurrent TP53 and KRAS alterations. 5,8 Whether these two tumours represent spectral ends of the same entity needs further clarification.We document, for the first time, an innocuous presentation of SMARCA4-DTS wherein a small tumour (w4 cm grossly) was incidentally detected in the soft tissue of chest wall around an ICD insertion site in a patient suffering from chronic empyema thoracis of uncertain aetiology for over 10 months. We believe it is unlikely that the SMARCA4-DTS was masquerading as chronic empyema as the initial computed tomography images do not show any mass lesion. The lung parenchyma was completely clear except for smoking related parenchymal changes. Although an autopsy was refused in this patient, the rapidly fatal outcome after development of tumour highlights its aggressiveness. A link with chronic infection/inflammation as an inciting/contributing factor for SMARCA4-DTS has not been noted previously and should be explored.