The Use of Reserpine in Ambulatory and Hospitalized Geriatric Psychotics

Sainz, Anthony

doi:10.1111/j.1749-6632.1955.tb42452.x

Cited by 17 publications

(8 citation statements)

References 1 publication

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“…One of the major problems anticipated with the psychologic tests in this study was the separation of the effects of the drugs (particularly reserpine) from the effects of the resultant hypotension. The effects of reserpine in senile psychiatric patients are reported to be decreased anxiety, tension, aggressiveness and hostility and increased interest in personal and social activities (36, 37). The thinking processes, memory and orientation do not appear to be directly influenced.…”

Section: Discussionmentioning

confidence: 99%

Effect of Hydrochlorothiazide‐reserpine Therapy on Cerebral Function in Elderly Hypertensive Patients*

Lindeman¹,

Bouthilet²,

Ashley³

et al. 1963

J American Geriatrics Society

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The opinion often has been expressed that lowering of the blood pressure should be attempted only with great caution in elderly hypertensive patients, especially those with cerebrovascular disease (1-6). Fear that reduction of the arterial pressure may precipitate a stroke or cause deterioration of cerebral function undoubtedly has prevented treatment in many such cases.Yet even in the mild diastolic hypertension and the systolic hypertension often attributed to arteriosclerosis there is a definite increase in the incidence of stroke and in the mortality rate (7). Reduction of arterial pressure in patients with moderate to severe hypertension results in a decreased incidence of stroke and a lowered mortality rate (8-13). Presumably all forms of hypertension, even in elderly persons with primarily systolic elevations of blood pressure, may benefit from treatment, as manifested by a reduced incidence of cerebrovascular and other complications of the disease.This study was made in an attempt to determine whether or not elderly hypertensive subjects can tolerate a substantial reduction in blood pressure for a prolonged period (five to six weeks) without changes in cerebral function. Antihypertensive agents (reserpine and hydrochlorothiazide) or identical-appearing placebos were administered over periods of five to six weeks. A series of psychologic tests, recognized to be a sensitive indicator of changes in intellectual efficiency, was given before and after the medications for the purpose of yuantitative assessment of the effects of therapy. METHODS PatientsA single blood pressure determination was obtained on each of 2,000 patients at the Central State (Griffin Memorial) Hospital in Norman, Oklahoma, as part of a multiphasic chronic-disease screening program carried out during the summer of 19G1. Patients past the age of 60 with an initial systolic blood pressure above lG0 mm. Hg or a diastolic pressure above 100 mm. Hg were seen in the out-patient clinic for further evaluation. If their blood ~~~~~~ ~ ~

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Section: Discussionmentioning

confidence: 99%

Effect of Hydrochlorothiazide‐reserpine Therapy on Cerebral Function in Elderly Hypertensive Patients*

Lindeman¹,

Bouthilet²,

Ashley³

et al. 1963

J American Geriatrics Society

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“…There were no suicidal trends reported in comparator arms. Individual symptoms of depression were reported as a side effect to reserpine treatment; fatigue was reported in 10 studies (Bennett et al, 1956;Fife et al, 1959;Finn et al, 1955;Hodgkinson, 1956;Kirkegaard et al, 1958;Lemieux et al, 1956;Sainz, 1955;Vakil, 1949;Veselinović et al, 2011;Wachspress et al, 1956). Concentration deficits were reported in Veselinović et al (2011); insomnia and sleep disturbances were reported in Fife et al (1959), Vakil (1949, Pellerito (1956) and Veselinović et al (2011).…”

Section: Secondary Outcomesmentioning

confidence: 99%

The effects of reserpine on depression: A systematic review

et al. 2022

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Background: Reserpine is an effective antihypertensive drug, but its role in routine practice has declined such that it is rarely used. This is largely based on the assumption that reserpine causes depression. This assumption was a foundation for the original monoamine hypothesis of depression. However, there remains conflicting evidence as to whether reserpine causes depression, and no systematic review of available evidence. Aims: We systematically reviewed evidence on effects of reserpine on depressive and related symptoms (e.g. anxiety, suicidal ideation). Method: Electronic searches of MEDLINE, Embase and PsycINFO were conducted to identify studies up to 14 February 2021. Studies of any methodological design involving reserpine-treated and reserpine-untreated conditions, in any adult human population, were included and a narrative synthesis of findings was undertaken. Risk of bias (RoB) was examined using ROBINS-I. Results: Of the 35 studies meeting inclusion criteria, 9 were randomised controlled trials. Eleven studies reported some depressogenic effects, 13 reported no effect and 11 reported putative antidepressant effects. Studies identifying depressive effects were more likely to examine people without psychiatric disorders at baseline, while studies identifying a potential antidepressant effect tended to treat fewer participants for shorter durations, at higher doses. Around one-third of studies conducted in people with psychiatric disorders showed beneficial effects on depression symptoms. 30/35 studies were at high RoB. Conclusions: Associations between reserpine and depression are inconsistent and limited by a lack of high-quality evidence. Due to reserpine’s apparently complex effects, we urge nuance rather than simplicity surrounding the monoamine hypothesis of depression.

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“…Hach (32) concluded that reserpine in doses up to 15 mg. per day caused a reduction of tension, anxiety, and fear in patients with schizophrenic reactions and various types of depression. Additional workers have reported that reserpine causes improvement in geriatric psychotic patients (98), chronic schizophrenics (87,109), psychoneurotic patients (104), irritable and hypertonic infants (108), children with enuresis (70), children with behavior disorders (122), and patients suffering from the abstinence syndrome of narcotic withdrawal (17). Though improvement following reserpine appears to be independent of the patient's diagnosis, it is generally believed that reserpine produces most improvement in patients who demonstrate a high degree of disturbed behavior, fear, hostility, anxiety, or tension.…”

Section: Beneficial Effects Of Reserpinementioning

confidence: 99%