The use of QuikClot combat gauze in cervical and vaginal hemorrhage

Vilardo, Nicole; Feinberg, Jacqueline; Black, Jonathan; Ratner, Elena

doi:10.1016/j.gore.2017.07.012

Cited by 17 publications

(8 citation statements)

References 16 publications

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“…We also found that the application of this local hemostatic on the cervical wound site was effective in reducing both delayed onset and early onset hemorrhage. The results of this study are consistent with those of earlier studies, which reported that a kaolin-impregnated gauze such as a QuikClot combat gauze, has significant hemostatic effects in various surgical fields [13,14]. Delayed hemorrhage, defined as bleeding occurring from the surgical site several days after the surgery, is the most distressing complication of the LEEP for the physicians in outpatient settings.…”

Section: Discussionsupporting

confidence: 91%

“…Moreover, in some clinical settings, creative approaches for achieving hemostasis are required to attain rapid hemostasis and/or avoid additional surgical procedures, which could be associated with higher morbidity. Vilardo et al [14] reported three cases in which they found a kaolin-impregnated gauze was found to have a significant clinical efficacy in controlling cervical and vaginal hemorrhage. In all three cases, excellent hemostasis was achieved without any identifiable adverse effects.…”

Section: Discussionmentioning

confidence: 99%

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Efficacy of a kaolin-impregnated gauze in the prevention of postoperative bleeding after cervical conization

Song¹,

Kim²,

Lee³

2021

European Journal of Gynaecological Oncology

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To evaluate the efficacy of a kaolin-impregnated gauze in preventing postoperative bleeding after a loop electrosurgical excision procedure (LEEP). Methods: The medical records of 1322 women who underwent a LEEP at a university hospital were retrospectively reviewed, of which 1006 patients who fulfilled the inclusion criteria were included in the final analysis. During the study period, the bleeding in patients undergoing a LEEP was managed with the application of a kaolin-impregnated gauze (treatment group, n = 539) or without application of a kaolin-impregnated gauze (control group, n = 467). The primary outcome measure was the incidence of postoperative bleeding requiring hemostatic intervention after a LEEP. A logistic regression model was used to identify the clinical variables for postoperative bleeding. Results: The baseline characteristics were similar between the two study groups. Postoperative vaginal bleeding necessitating an intervention was observed in 12.8% of the study population (129 of 1006 women), with a significant difference between the two groups (9.3% in the treatment group vs. 16.9% in the control group; p < 0.001). On multivariate analysis, significantly lower postoperative bleeding was observed with the use of a kaolinimpregnated gauze than without its use (odds ratio = 0.496; 95% confidence interval = 0.267-0.870; p = 0.009). Conclusions: Prophylactic use of a kaolin-impregnated gauze reduced the incidence of postoperative bleeding after a LEEP.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Efficacy of a kaolin-impregnated gauze in the prevention of postoperative bleeding after cervical conization

Song¹,

Kim²,

Lee³

2021

European Journal of Gynaecological Oncology

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“…Menurut RISKESDAS, Provinsi NTB tentang teknik perawatan tali pusat pada bayi baru lahir dengan ramuan tradisional sebesar 10,4%, obat tabur 2,7%, betadin alkohol 4,8% dan tidak diberikan apa-apa 45%(Leante Castellanos et al, 2019). Di Kota Mataram, kejadian kasus komplikasi yang banyak terjadi pada bayi adalah BBLR dengan kasus sebesar 266, asfiksia sebesar 216, sepsis sebesar 31, cacat bawaan sebesar 23, dan lain-lain sebesar 16 kasus (Vilardo et al, 2017).…”

Section: World Health Organization (Who)unclassified

Teknik Perawatan Tali Pusat terhadap Pelepasan Tali Pusat

Din'ni

Meliati

2021

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The incidence of infection in newborns (BBL) in Indonesia is 24%-34%. Infection in BBL is the number 2 cause of neonatal death by 49%-60%. Neonatal mortality in developing countries is 50% due to umbilical cord infection, sepsis and neonatal tetanus. The purpose of this study was to analyze the effectiveness of umbilical cord care in newborns using dry open technique and sterile gauze against umbilical cord rupture. The type of research was pre-experimental post-test only design and the sample of this study was 30 newborns at the Puskesmas with purposive sampling technique. The study was conducted for 3 months. The results showed that the umbilical cord care technique with the dry open method made the umbilical cord detach faster than the sterile gauze method. The time for releasing the umbilical cord with the dry open method took 123.8 hours and the time for releasing the umbilical cord with sterile gauze took 170.8 hours. The results of the analysis showed the significance value of 0.004 and the Levin test result of 138%. Conclusion there is no more effective between sterile gauze and dry open umbilical cord treatment against umbilical cord detachment. Suggestions for midwives and health workers can socialize postpartum mothers in umbilical cord care for newborns using open techniques and sterile gauze.

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“…These dressing could be classified into polysaccharide-based (e.g., chitin/chitosan), zeolite/kaolin-based, dry fibrin sealant, microporous polysaccharide hemospheres, and hydrophilic polymers of potassium salts. For example, kaolin is the active hemostatic agent in QuikClot ® Combat Gauze that is the hemostatic dressing of choice used on the battlefield [ 6 , 7 , 8 ]. Kaolin is aluminum silicate that activates the intrinsic pathway of coagulation via concentrating clotting factors through the rapid absorption of the water content of blood at the bleeding site.…”

Section: Introductionmentioning

confidence: 99%

Design and Preclinical Evaluation of Chitosan/Kaolin Nanocomposites with Enhanced Hemostatic Efficiency

Elsabahy

Hamad

2021

Marine Drugs

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In the current study, hemostatic compositions including a combination of chitosan and kaolin have been developed. Chitosan is a marine polysaccharide derived from chitins, a structural component in the shells of crustaceans. Both chitosan and kaolin have the ability to mediate a quick and efficient hemostatic effect following immediate application to injury sites, and thus they have been widely exploited in manufacturing of hemostatic composites. By combining more than one hemostatic agent (i.e., chitosan and kaolin) that act via more than one mechanism, and by utilizing different nanotechnology-based approaches to enhance the surface areas, the capability of the dressing to control bleeding was improved, in terms of amount of blood loss and time to hemostasis. The nanotechnology-based approaches utilized to enhance the effective surface area of the hemostatic agents included the use of Pluronic nanoparticles, and deposition of chitosan micro- and nano-fibers onto the carrier. The developed composites effectively controlled bleeding and significantly improved hemostasis and survival rates in two animal models, rats and rabbits, compared to conventional dressings and QuikClot® Combat Gauze. The composites were well-tolerated as demonstrated by their in vivo biocompatibility and absence of clinical and biochemical changes in the laboratory animals after application of the dressings.

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The use of QuikClot combat gauze in cervical and vaginal hemorrhage

Cited by 17 publications

References 16 publications

Efficacy of a kaolin-impregnated gauze in the prevention of postoperative bleeding after cervical conization

Efficacy of a kaolin-impregnated gauze in the prevention of postoperative bleeding after cervical conization

Teknik Perawatan Tali Pusat terhadap Pelepasan Tali Pusat

Design and Preclinical Evaluation of Chitosan/Kaolin Nanocomposites with Enhanced Hemostatic Efficiency

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