THE USE OF PROSTAGLANDIN E₂ IN THE MANAGEMENT OF INTRAUTERINE DEATH, MISSED ABORTION AND HYDATIDIFORM MOLE

Abstract

Intravenous infusion of prostaglandin E, was used successfully to evacuate the uterus in seven cases of intrauterine death, five cases of missed abortion and one case of hydatidiform mole. Haemorrhage associated with hypofibrinogenaemia occurred in one patient with an intrauterine death.

INTRAVENOUS OXYTOCIN AND ORAL PROSTAGLANDIN E2 FOR RIPENING OF THE UNFAVOURABLE CERVIX

“…Brummer (1971) and Gillespie (1972) suggested that the prior administration of prostaglandin E, (PGE2) enhanced the uterine response to subsequently administered oxytocin. Other workers showed PGs to be effective in the induction of labour in unfavourable conditions (Anderson et al, 1971;Calder and Embrey, 1973;Filshie, 1971 ;Friedman and Sachtleben, 1974;Karim et al, 1970). Karim and Sharma (1972) showed the length of labour following P G administration to be shortened.…”

Prostaglandins

“…Several small studies have demonstrated the safety and effectiveness of prostaglandins (Karim, 1970;Filshie, 1971;Pedersen et al, 1972). Several small studies have demonstrated the safety and effectiveness of prostaglandins (Karim, 1970;Filshie, 1971;Pedersen et al, 1972).…”

SIMULTANEOUS INTRAVENOUS INFUSION OF PROSTAGLANDIN E2 (PGE2) AND OXYTOCIN IN THE MANAGEMENT OF INTRAUTERINE DEATH OF THE FETUS, MISSED ABORTION AND HYDATIDIFORM MOLE

“…Karim (1970) and Filshie (1971) have each reported the successful termination of pregnancy in one patient with a hydatidiform mole by intravenous PGE, infusion. It appeared that if the gestation sac remained intact, then the abortion was more likely to be complete whereas, if the sac ruptured in labour, then the placenta tended to be retained.…”

“…It appeared that if the gestation sac remained intact, then the abortion was more likely to be complete whereas, if the sac ruptured in labour, then the placenta tended to be retained. Karim (1970) and Filshie (1971) have each reported the successful termination of pregnancy in one patient with a hydatidiform mole by intravenous PGE, infusion. We have managed five patients in a manner similar to that employed with missed abortions and found that the results were equally satisfactory.…”