INTRAVENOUS OXYTOCIN AND ORAL PROSTAGLANDIN E<sub>2</sub> FOR RIPENING OF THE UNFAVOURABLE CERVIX

Valentine, B. H.

doi:10.1111/j.1471-0528.1977.tb12506.x

Cited by 33 publications

(8 citation statements)

References 13 publications

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“…In a study by Golbus & Creasy (1977) the Bishop score was found to increase when PGE2 was used for priming the cervix before induction (7). Similar observations were made by Valentine (1977) and also by Pearce (1977) in a double-blind study (11, 10). However, Friedman & Sachtleben (1975) could not find any priming effect when using PGE2 tablets in their double-blind study (6).…”

supporting

confidence: 86%

Priming and Induction of Labor with Oral PGE₂ in Patients with Low Bishop Score

Somell

Larsson

1983

Acta Obstet Gynecol Scand

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supporting

confidence: 86%

Priming and Induction of Labor with Oral PGE₂ in Patients with Low Bishop Score

Somell

Larsson

1983

Acta Obstet Gynecol Scand

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“…(Hannah 1996; Jagani 1984; McCaul 1997; Puertas 1996; Ray 1992; Roberts 1986; Van Der Walt 1989; Wiqvist 1986). Twenty-five trials compared oxytocin with a policy of expectant management (Akyol 1999; Alcalay 1996; Chang 1997; Damania 1992; Duff 1984; Grant 1992; Hannah 1996; Hjertberg 1996; Jagani 1984; Ladfors 1996; McCaul 1997; McQueen 1992; Morales 1986; Natale 1994; Ottervanger 1996; Puertas 1996; Ray 1992; Roberts 1986; Rydhstrom 1991; Sperling 1993; Tamsen 1990; Valentine 1977; Van Der Walt 1989; Wagner 1989; Wiqvist 1986). Twenty-seven trials compared oxytocin with vaginal PGE2 (Andersen 1990; Atad 1996; Chua 1991; Egarter 1987; Ekman 1986; Ekman-Ordeberg 1985; Griffith-Jones 1990; Hannah 1996; Herabutya 1991; Jagani 1984; Lange 1984; Legarth 1987; Lyndrup 1989; Lyndrup 1990; Macer 1984; Magos 1983; McCaul 1997; McQueen 1990; Olmo 2001; Pollnow 1996; Ray 1992; Roberts 1986; Rymer 1992; Silva-Cruz 1988; Valadan 2005; Van Der Walt 1989; Wilson 1978).…”

Section: Resultsmentioning

confidence: 99%

Intravenous oxytocin alone for cervical ripening and induction of labour

Alfirević

Kelly

Dowswell

2009

Cochrane Database of Systematic Reviews

155

129

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Background Oxytocin is the commonest induction agent used worldwide. It has been used alone, in combination with amniotomy or following cervical ripening with other pharmacological or non-pharmacological methods. Objectives To determine the effects of oxytocin alone for third trimester cervical ripening and induction of labour in comparison with other methods of induction of labour or placebo/no treatment. Search methods We searched the Cochrane Pregnancy and Childbirth Group’s Trials Register (January 2009) and bibliographies of relevant papers. Selection criteria Randomised and quasi-randomised trials comparing intravenous oxytocin with placebo or no treatment, or with prostaglandins (vaginal or intracervical) for third trimester cervical ripening or labour induction. Data collection and analysis Two review authors independently assessed eligibility and carried out data extraction. Main results Sixty-one trials (12,819 women) are included. When oxytocin inductions were compared with expectant management, fewer women failed to deliver vaginally within 24 hours (8.4% versus 53.8%, risk ratio (RR) 0.16, 95% confidence interval (CI) 0.10 to 0.25). There was a significant increase in the number of women requiring epidural analgesia (RR 1.10, 95% CI 1.04 to 1.17). Fewer women were dissatisfied with oxytocin induction in the one trial reporting this outcome (5.9% versus 13.7%, RR 0.43, 95% CI 0.33 to 0.56). Compared with vaginal prostaglandins, oxytocin increased unsuccessful vaginal delivery within 24 hours in the two trials reporting this outcome (70% versus 21%, RR 3.33, 95% CI 1.61 to 6.89). There was a small increase in epidurals when oxytocin alone was used (RR 1.09, 95% CI 1.01 to 1.17). Most of the studies included women with ruptured membranes, and there was some evidence that vaginal prostaglandin increased infection in mothers (chorioamnionitis RR 0.66, 95% CI 0.47 to 0.92) and babies (use of antibiotics RR 0.68, 95% CI 0.53 to 0.87). These data should be interpreted cautiously as infection was not pre-specified in the original review protocol. When oxytocin was compared with intracervical prostaglandins, there was an increase in unsuccessful vaginal delivery within 24 hours (50.4% versus 34.6%, RR 1.47, 95% CI 1.10 to 1.96) and an increase in caesarean sections (19.1% versus 13.7%, RR 1.37, 95% CI 1.08 to 1.74) in the oxytocin group. Authors’ conclusions Comparison of oxytocin with either intravaginal or intracervical PGE2 reveals that the prostaglandin agents probably increase the chances of achieving vaginal birth within 24 hours. Oxytocin induction may increase the rate of interventions in labour. A suggestion that for women with prelabour rupture of membranes induction with vaginal prostaglandin may increase risk of infection for mother and baby warrants further study.

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“…Its exogenous use causes enough uterine activity to produce cervical dilation and fetal descent without uterine hyperstimulation or fetal distress (2). However, oxytocin is a poor cervical ripener (12, 102–105). It is usually not effective to use this hormone for labor induction without the presence of a ripe cervix.…”

Section: Methods Of Cervical Ripening and Labor Inductionmentioning

confidence: 99%

Methods of cervical ripening and labor induction

Summers¹

1997

Journal of Nurse-Midwifery

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INTRAVENOUS OXYTOCIN AND ORAL PROSTAGLANDIN E₂ FOR RIPENING OF THE UNFAVOURABLE CERVIX

Cited by 33 publications

References 13 publications

Priming and Induction of Labor with Oral PGE₂ in Patients with Low Bishop Score

Priming and Induction of Labor with Oral PGE₂ in Patients with Low Bishop Score

Intravenous oxytocin alone for cervical ripening and induction of labour

Methods of cervical ripening and labor induction

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INTRAVENOUS OXYTOCIN AND ORAL PROSTAGLANDIN E2 FOR RIPENING OF THE UNFAVOURABLE CERVIX

Cited by 33 publications

References 13 publications

Priming and Induction of Labor with Oral PGE2 in Patients with Low Bishop Score

Priming and Induction of Labor with Oral PGE2 in Patients with Low Bishop Score

Intravenous oxytocin alone for cervical ripening and induction of labour

Methods of cervical ripening and labor induction

Contact Info

Product

Resources

About

INTRAVENOUS OXYTOCIN AND ORAL PROSTAGLANDIN E₂ FOR RIPENING OF THE UNFAVOURABLE CERVIX

Priming and Induction of Labor with Oral PGE₂ in Patients with Low Bishop Score

Priming and Induction of Labor with Oral PGE₂ in Patients with Low Bishop Score