The Use of Probiotics Combined with Exercise Affects Thiol/Disulfide Homeostasis, an Oxidative Stress Parameter

Kayacan, Yıldırım; Kola, Aybike Zeynep; Guandalini, Stefano; Yazar, Hayrullah; Söğüt, Mehtap Ünlü

doi:10.3390/nu14173555

Cited by 3 publications

(1 citation statement)

References 34 publications

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“…Them; infertility, pre-eclampsia and coronary artery diseases are only a few of them [7][8][9]. In addition, recent oxidative stress studies have focused on thiol-disulfide balance [10][11][12]. Despite all these scientific studies, we have yet to conduct a comparative study on oxidative stress in radial angiography patients with OSI index with healthy individuals.…”

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confidence: 99%

"Investigation of Oxidative Stress Index in Radial Angio Patients"

Yazar

2023

BJSTR

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Background:The study aims to determine the oxidative stress index in blood plasma in radial coronary angiography patients and compare it with a control group of healthy individuals.Methods: In our study, which lasted approximately six months, 79 adult samples were collected. The patient group comprised 35 adults, and the control group included 44 healthy adults. As an oxidative stress marker, total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) were accepted. Patient blood samples were taken into tubes with lithium heparin, and plasmas were obtained after centrifugation. Subsequently, the biochemistry laboratory analyzed TAS and TOS in a fully automatic autoanalyzer. The OSI index is; Calculated according to the formula [(TOS/TAS) ×100]. Rel Assay Diagnostics brand kits were used in the study. The statistical significance level was accepted as p<0.05.Results: As a result of descriptive statistics, the mean and standard deviation values of TAS (mmol/L) values in the patient and control groups were calculated as 1.59 (mmol/L) and 1.59 (mmol/L), respectively. TOS values were calculated as 8.95 (mmol/L) and 8.97 (µmol/L), respectively, while OSI values were calculated as 5.81 (Arbitrary Units, AU) and 5.69 (AU). A positive, weak, statistically significant correlation was found between TAS and TOS values (p=0.029). There was a negative, strong, and meaningful relationship between TAS and OSI values (p<0.001). Found a positive, moderate, significant relationship between TOS and OSI values (p<0.001). There was no significant difference between the TAS and TOS values in the patient and control groups. The OSI values of the patient group were higher than the control group, but this was not significant (p=0.65). Conclusion:OSI values in the angiography patient group were higher than in the control group; although it is statistically insignificant, this result is subject to further studies.

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Section: Introductionmentioning

confidence: 99%

"Investigation of Oxidative Stress Index in Radial Angio Patients"

Yazar

2023

BJSTR

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Effect of Stanozolol and/or Cannabis Abuse on Hypertrophic Mechanism and Oxidative Stress of Male Albino Rat Cardiac Tissue in Relation to Exercise: A Sport Abuse Practice

Mowaad,

Elgohary,

ElShebiney

2024

Cardiovasc Toxicol

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Adolescents commonly co-abuse many drugs including anabolic androgenic steroids either they are athletes or non-athletes. Stanozolol is the major anabolic used in recent years and was reported grouped with cannabis. The current study aimed at evaluating the biochemical and histopathological changes related to the hypertrophic effects of stanozolol and/or cannabis whether in condition of exercise practice or sedentary conditions. Adult male Wistar albino rats received either stanozolol (5 mg/kg, s.c), cannabis (10 mg/kg, i.p.), and a combination of both once daily for two months. Swimming exercise protocol was applied as a training model. Relative heart weight, oxidative stress biomarkers, cardiac tissue fibrotic markers were evaluated. Left ventricular morphometric analysis and collagen quantification was done. The combined treatment exhibited serious detrimental effects on the heart tissues. It increased heart tissue fibrotic markers (Masson’s trichrome stain (p < 0.001), cardiac COL3 (p < 0.0001), and VEGF-A (p < 0.05)), lowered heart glutathione levels (p < 0.05) and dramatically elevated oxidative stress (increased malondialdehyde (p < 0.0001) and 8-OHDG (p < 0.0001)). Training was not ameliorating for the observed effects. Misuse of cannabis and stanozolol resulted in more hypertrophic consequences of the heart than either drug alone, which were at least largely assigned to oxidative stress, heart tissue fibrotic indicators, histological alterations, and morphometric changes.

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Lactic Acid Bacteria-Derived Exopolysaccharides Mitigate the Oxidative Response via the NRF2-KEAP1 Pathway in PC12 Cells

Şirin

2023

CIMB

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Parabiotics, including L-EPSs, have been administered to patients with neurodegenerative disorders. However, the antioxidant properties of L-EPSs against H2O2-induced oxidative stress in PC12 cells have not been studied. Herein, we aimed to investigate the antioxidant properties of the L-EPSs, their plausible targets, and their mechanism of action. We first determined the amount of L-EPSs in Lactobacillus delbrueckii ssp. bulgaricus B3 and Lactiplantibacillus plantarum GD2 using spectrophotometry. Afterwards, we studied their effects on TDH, TOS/TAS, antioxidant enzyme activities, and intracellular ROS level. Finally, we used qRT-PCR and ELISA to determine the effects of L-EPSs on the NRF2-KEAP1 pathway. According to our results, the L-EPS groups exhibited significantly higher total thiol activity, native thiol activity, disulfide activity, TAS levels, antioxidant enzyme levels, and gene expression levels (GCLC, HO-1, NRF2, and NQO1) than did the H2O2 group. Additionally, the L-EPS groups caused significant reductions in TOS levels and KEAP1 gene expression levels compared with those in the H2O2 group. Our results indicate that H2O2-induced oxidative stress was modified by L-EPSs. Thus, we revealed that L-EPSs, which regulate H2O2-induced oxidative stress, could have applications in the field of neurochemistry.

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The Use of Probiotics Combined with Exercise Affects Thiol/Disulfide Homeostasis, an Oxidative Stress Parameter

Cited by 3 publications

References 34 publications

"Investigation of Oxidative Stress Index in Radial Angio Patients"

"Investigation of Oxidative Stress Index in Radial Angio Patients"

Effect of Stanozolol and/or Cannabis Abuse on Hypertrophic Mechanism and Oxidative Stress of Male Albino Rat Cardiac Tissue in Relation to Exercise: A Sport Abuse Practice

Lactic Acid Bacteria-Derived Exopolysaccharides Mitigate the Oxidative Response via the NRF2-KEAP1 Pathway in PC12 Cells

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