"Investigation of Oxidative Stress Index in Radial Angio Patients"

Abstract

Background:The study aims to determine the oxidative stress index in blood plasma in radial coronary angiography patients and compare it with a control group of healthy individuals.Methods: In our study, which lasted approximately six months, 79 adult samples were collected. The patient group comprised 35 adults, and the control group included 44 healthy adults. As an oxidative stress marker, total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) were accepted. Patient blood samples were taken into tubes with lithium heparin, and plasmas were obtained after centrifugation. Subsequently, the biochemistry laboratory analyzed TAS and TOS in a fully automatic autoanalyzer. The OSI index is; Calculated according to the formula [(TOS/TAS) ×100]. Rel Assay Diagnostics brand kits were used in the study. The statistical significance level was accepted as p<0.05.Results: As a result of descriptive statistics, the mean and standard deviation values of TAS (mmol/L) values in the patient and control groups were calculated as 1.59 (mmol/L) and 1.59 (mmol/L), respectively. TOS values were calculated as 8.95 (mmol/L) and 8.97 (µmol/L), respectively, while OSI values were calculated as 5.81 (Arbitrary Units, AU) and 5.69 (AU). A positive, weak, statistically significant correlation was found between TAS and TOS values (p=0.029). There was a negative, strong, and meaningful relationship between TAS and OSI values (p<0.001). Found a positive, moderate, significant relationship between TOS and OSI values (p<0.001). There was no significant difference between the TAS and TOS values in the patient and control groups. The OSI values of the patient group were higher than the control group, but this was not significant (p=0.65). Conclusion:OSI values in the angiography patient group were higher than in the control group; although it is statistically insignificant, this result is subject to further studies.