The Use of Plasma Creatinine Concentration for Estimating Glomerular Filtration Rate in Infants, Children, and Adolescents

Schwartz, George J.; Brion, Luc P.; Spitzer, Adrian

doi:10.1016/s0031-3955(16)36251-4

Cited by 1,602 publications

(1,090 citation statements)

References 77 publications

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“…In all the other children there was no apparent cause for their poor growth. In cases 1, 2 and 4 the cGFR 5 at presentation and throughout follow-up was normal. Case 3 had an elevated creatinine and depressed cGFR of 45 ml/min/1.73 m 2 at presentation, but this improved to a creatinine value of 82 mol/l and a cGFR of 70 ml/min/1.73 m 2 at her last follow-up at 10.5 years of age.…”

Section: Discussionmentioning

confidence: 82%

Hypertension: a cause of growth impairment

et al. 2002

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Section: Discussionmentioning

confidence: 82%

Hypertension: a cause of growth impairment

et al. 2002

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“…Patient characteristics are listed in Table 1. Graft function was determined by measuring serum creatinine levels and by using the Schwartz formula to estimate glomerular filtration rate (GFR) (22).…”

Section: Patientsmentioning

confidence: 99%

Increased Urologic Complications in Children After Kidney Transplants for Obstructive and Reflux Uropathy

Khositseth

Askiti

Nevins

et al. 2007

American Journal of Transplantation

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In the cyclosporine era, reports on pediatric kidney transplant (KTx) patients with obstructive and reflux uropathy are limited by small numbers, short followup, and/or lack of control groups. Our single-center study evaluated long-term outcomes (patient and graft survival, urinary tract infections [UTIs], urologic complications) in a large cohort of KTx recipients (<20 years old). We matched our 117 study patients with obstructive and reflux uropathy with 117 controls whose KTx was needed for other reasons; all 234 underwent their KTx between April 25, 1984, and October 23, 2002. The mean age was 8.0 ± 6.2 years; mean follow-up, 133 ± 67 months. The urologic complication rate was higher in study patients (43%) than in controls (11%) (p < 0.0001), as was the UTI rate (45% vs. 2%; p < 0.0001). The metabolic acidosis and UTI rates were higher in study patients who did (vs. did not) undergo bladder augmentation (p < 0.0001). We found no significant difference between study patients and controls in patient or graft survival, acute or chronic rejection, or mean estimated glomerular filtration rates. Unique to our study is the finding of higher metabolic acidosis and UTI rates in study patients who underwent bladder augmentation.

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“…This equation incorporates age, sex, height, weight, and serum creatinine levels into its estimation of GFR. For patients under 12 years of age, we used the Schwartz formula [23], which does not take weight into account in its estimation. These formulae for GFR were used because excessive and wide-ranging results were obtained in children and adults using the Modification of Diet in Renal Disease study formula, which lacks a weight term, was designed for creatinines from 1.2 to 7.0 mg/dl, and has never been validated in a sickle cell population [24,25].…”

Section: Phenotype Definitionmentioning

confidence: 99%

Estimated glomerular filtration rate in sickle cell anemia is associated with polymorphisms of bone morphogenetic protein receptor 1B

Nolan

Cohen

et al. 2006

American J Hematol

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Renal disease is common in sickle cell anemia. In this exploratory work, we used data from a longitudinal study of the natural history of sickle cell disease to examine the hypothesis that polymorphisms (SNPs) in selected candidate genes are associated with glomerular filtration rate (GFR). DNA samples and clinical and laboratory data were available for 1,140 patients with sickle cell anemia. GFR was estimated using the Cockcroft-Gault and Schwartz formulas for adults and children, respectively. We examined *175 haplotype tagging (ht) SNPs in about 70 genes of the TGFb/BMP pathway for their association with GFR using linear regression. Four SNPs in BMPR1B, a bone morphogenetic protein (BMP) receptor gene, yielded statistically significant associations (P values ranging from 0.015 to 0.046). Three haplotypes in this gene were also associated with GFR. The TGF-b/BMP pathway has been associated with the development of diabetic nephropathy, which has some features in common with sickle cell nephropathy. Our results suggest that, as with other subphenotypes of sickle cell disease, renal function may be genetically modulated. Am. J. Hematol. 82:179-184, 2007. V V C 2006 Wiley-Liss, Inc.

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The Use of Plasma Creatinine Concentration for Estimating Glomerular Filtration Rate in Infants, Children, and Adolescents

Cited by 1,602 publications

References 77 publications

Hypertension: a cause of growth impairment

Hypertension: a cause of growth impairment

Increased Urologic Complications in Children After Kidney Transplants for Obstructive and Reflux Uropathy

Estimated glomerular filtration rate in sickle cell anemia is associated with polymorphisms of bone morphogenetic protein receptor 1B

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