The use of PEGylated poly [2-(N,N-dimethylamino) ethyl methacrylate] as a mucosal DNA delivery vector and the activation of innate immunity and improvement of HIV-1-specific immune responses

“…Pulmonary administration of the polyplexes elicited an immune response and protected the immunized mice against viral challenge. PEGylated poly [2-(N,N-dimethylamino)ethyl methacrylate] was used to deliver HIV gag DNA vaccine [53]. Intranasal administration of the polyplexes was observed to enhance the gag-specific serum IgG levels and IFN-g secreting splenocytes in mice as compared to the naked DNA vaccinetreated group.…”

Section: Synthetic Polymer-based Nanodelivery Systemsmentioning

confidence: 99%

“…Electrostatic polyplexes have also been tested for their utility in delivering subunit antigens [51] or plasmid DNA vaccines [52,53]. Hepatitis B surface antigen was loaded onto cationic Lpoly lactic acid microspheres via the formation of electrostatic complexes [51].…”

Section: Synthetic Polymer-based Nanodelivery Systemsmentioning

confidence: 99%

Nanotechnology and vaccine development

Kim

Park

Shon

et al. 2014

Asian Journal of Pharmaceutical Sciences

114

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Emulsions Polymeric nanocarriersCarbon nanomaterials a b s t r a c t Despite the progress of conventional vaccines, improvements are clearly required due to concerns about the weak immunogenicity of these vaccines, intrinsic instability in vivo, toxicity, and the need for multiple administrations. To overcome such problems, nanotechnology platforms have recently been incorporated into vaccine development.Nanocarrier-based delivery systems offer an opportunity to enhance the humoral and cellular immune responses. This advantage is attributable to the nanoscale particle size, which facilitates uptake by phagocytic cells, the gut-associated lymphoid tissue, and the mucosa-associated lymphoid tissue, leading to efficient antigen recognition and presentation. Modifying the surfaces of nanocarriers with a variety of targeting moieties permits the delivery of antigens to specific cell surface receptors, thereby stimulating specific and selective immune responses. In this review, we introduce recent advances in nanocarrierbased vaccine delivery systems, with a focus on the types of carriers, including liposomes, emulsions, polymer-based particles, and carbon-based nanomaterials. We describe the remaining challenges and possible breakthroughs, including the development of needlefree nanotechnologies and a fundamental understanding of the in vivo behavior and stability of the nanocarriers in nanotechnology-based delivery systems.

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“…Recent studies suggested that nanotechnology could play a pivotal role in HIV-1 therapeutics and vaccine design [10,16,17,[17][18][19][20][21][22][23][24][25][26]. Nanoparticles are being proposed as new carriers to ameliorate DC antigen loading, which is important in DC-based vaccine approaches [9].…”

Section: Introductionmentioning

confidence: 99%