The Use of Oral Radiographic Contrast Agents in the Management of Hyperthyroidism

Fontanilla, Joy C.; Schneider, Arthur B.; Sarne, David

doi:10.1089/105072501750302868

Cited by 24 publications

(12 citation statements)

References 69 publications

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“…1CTP, the marker of bone resorption, has convincingly been shown to correlate to free T 4 and T 3 concentrations [27, 28]. We found that in the entire group of patients, the serum levels of free T 4 and 1CTP were decreased 1 year after hemithyroidectomy.…”

Section: Discussionsupporting

confidence: 52%

Decreased Levels of Ionized Calcium One Year after Hemithyroidectomy: Importance of Reduced Thyroid Hormones

Lindblom¹,

Valdemarsson

Lindergård³

et al. 2001

Horm Res Paediatr

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Background: Previously we have found reduced levels of total serum calcium and 1,25(OH)₂D₃ despite an unaltered stimulated parathyroid hormone (PTH) secretion 1 year after hemithyroidectomy. The present study was undertaken to elucidate the possible relationship between calcium homeostasis, thyroid hormones and bone resorption in a group of 45 consecutive patients subjected to hemithyroidectomy because of a solitary nodule. All patients had free T₄ and T₃ levels within normal range preoperatively. Methods: Thyroid hormones, bone mineral and biochemical variables known to reflect calcium homeostasis were studied. Patients were divided into three separate groups depending on their pre- and postoperative thyroid hormone status. Results: One year postoperatively, serum levels of free T₄ were decreased and that of thyrotropin (TSH) increased in the entire group of patients. The concentration of ionized calcium was reduced from 1.25 ± 0.05 to 1.22 ± 0.04 (p < 0.001) despite an unaltered PTH value (2.8 ± 1.0 vs. 3.1 ± 1.5, p = 0.50). A significant reduction in C-terminal telopeptide type 1 collagen (1CTP) indicated decreased bone resorption 1 year after surgery (p < 0.05). Subgroup analysis showed that a reduction in ionized calcium was seen only among patients with a postoperative decrease in free T₄. Patients with subclinical hyperthyroidism preoperatively presented the lowest postoperative levels of ionized calcium, significantly reduced levels of 1CTP and increased levels of phosphate and creatinine. Multiple linear regression analysis showed that age (p < 0.05) and postoperatively changed serum levels of TSH (p < 0.05), creatinine (p < 0.05), phosphate (p < 0.001) and FT₄ (p < 0.01) were independently associated with altered levels of ionized calcium. Conclusion: We conclude that the reduction in ionized calcium 1 year after hemithyroidectomy was not due to PTH deficiency. Instead our results suggest that the reduced effects of thyroid hormones on bone and kidney function is essential.

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Section: Discussionsupporting

confidence: 52%

Decreased Levels of Ionized Calcium One Year after Hemithyroidectomy: Importance of Reduced Thyroid Hormones

Lindblom¹,

Valdemarsson

Lindergård³

et al. 2001

Horm Res Paediatr

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“…The use of oral radiographic contrast agents like IOP may be useful in the treatment of thyrotoxicosis before surgery, in neonatal hyperthyroidism and in massive L-T 4 ingestion, or when other antithyroid drugs are contraindicated (20). In the present study, the period of treatment with IOP or SSKI in association with anti-thyroid drugs was sufficient for all to achieve clinical euthyroidism before surgery.…”

Section: Discussionmentioning

confidence: 60%

Effect of iodine or iopanoic acid on thyroid Ca2+/NADPH-dependent H2O2-generating activity and thyroperoxidase in toxic diffuse goiters

Cardoso

Martins

Campos

et al. 2002

European Journal of Endocrinology

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Objective: The aim of the present study was to compare the effects of iopanoic acid (IOP) or a saturated solution of potassium iodide (SSKI) administration to patients with toxic diffuse goiters (TDG). Design: Patients with TDG are treated with thionamides and high doses of iodine preoperatively. In this study, two types of preoperative drug regimens were used: propylthiouracil or methimazole plus SSKI for 10 -15 days ðn ¼ 8Þ or IOP for 7 days ðn ¼ 6Þ: Methods: Serum thyroid hormones (total and free thyroxine (T 4 ), total tri-iodothyronine (T 3 ) and reverse T 3 (rT 3 ), were evaluated after 7 days of either SSKI or IOP treatment, and after 10 -15 days of SSKI administration. During thyroidectomy, samples of thyroid gland were obtained to evaluate thyroperoxidase and thyroid H 2 O 2 -generating activities. Results: Serum total T 3 was significantly decreased after 7 days of either treatment, and serum rT 3 was significantly increased in IOP-treated patients. Serum total and free T 4 were unaffected by 7 days of IOP treatment, but decreased after 7 days of SSKI treatment, although significantly diminished levels were only reached after a further 3-8 days of SSKI administration. During both drug regimens, serum TSH remained low (SSKI: 0:159^0:122; IOP: 0:400^0:109 mU=ml). Thyroperoxidase activity was significantly lower in thyroid samples from patients treated with SSKI for 10-15 days than in the thyroid glands from IOP-treated patients. However, thyroid H 2 O 2 generation was inhibited in samples from patients treated with either IOP or SSKI. Conclusions: We show herein that IOP treatment can be effective in the management of hyperthyroidism and that this drug inhibits thyroid NADPH oxidase activity, just as previously described for SSKI, probably due to its iodine content.

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“…Serum T 3 levels can decrease 36% to 77% within 6 to 12 hours and normalize within 2 to 5 days. 7 In contrast, thyroid hormone levels take 6 to 8 weeks to normalize with thionamides, such as propylthiouracil and methimazole. 9 After 24 hours of treatment, T 3 levels decreased by 58% with ipodate (1 g/d) compared with 23% with propylthiouracil (600 mg/d) in Graves disease patients.…”

Section: Discussionmentioning

confidence: 99%

Iopanoic Acid to Treat Acute Psychiatric Crisis Associated With Thyrotoxicosis

Way

Shen²,

Martinez³

2015

Journal of Clinical Psychopharmacology

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The Use of Oral Radiographic Contrast Agents in the Management of Hyperthyroidism

Cited by 24 publications

References 69 publications

Decreased Levels of Ionized Calcium One Year after Hemithyroidectomy: Importance of Reduced Thyroid Hormones

Decreased Levels of Ionized Calcium One Year after Hemithyroidectomy: Importance of Reduced Thyroid Hormones

Effect of iodine or iopanoic acid on thyroid Ca2+/NADPH-dependent H2O2-generating activity and thyroperoxidase in toxic diffuse goiters

Iopanoic Acid to Treat Acute Psychiatric Crisis Associated With Thyrotoxicosis

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