Radiation-related thyroid cancer continues to be a clinical concern for two reasons: the risks associated with the widespread use of radiation treatments for benign conditions in the middle of the last century persist for decades after exposure; and radiation continues to be an effective component of the treatment of several childhood malignancies. Patients who were irradiated in the head and neck area need to be evaluated for thyroid cancer, benign thyroid nodules, hyperparathyroidism, salivary-gland neoplasms and neural tumors, including acoustic neuromas. Radiation-related thyroid cancers appear to have the same clinical behavior as other thyroid cancers, but many irradiated patients are entering the age range when more aggressive neoplasms occur. In this paper, we review how to approach the clinical management of a patient with a history of radiation exposure in the thyroid area, and how to treat radiation-exposed patients who develop related neoplasms, especially thyroid cancer.

No abstract

Internet social networks have become a ubiquitous application allowing people to easily share text, pictures, and audio and video files. Popular networks include WhatsApp, Facebook, Reddit and LinkedIn. We present an extensive study of the usage of the WhatsApp social network, an Internet messaging application that is quickly replacing SMS messaging. In order to better understand people's use of the network, we provide an analysis of over 6 million messages from over 100 users, with the objective of building demographic prediction models using activity data. We performed extensive statistical and numerical analysis of the data and found significant differences in WhatsApp usage across people of different genders and ages. We also inputted the data into the Weka data mining package and studied models created from decision tree and Bayesian network algorithms. We found that different genders and age demographics had significantly different usage habits in almost all message and group attributes. We also noted differences in users' group behavior and created prediction models, including the likelihood a given group would have relatively more file attachments, if a group would contain a larger number of participants, a higher frequency of activity, quicker response times and shorter messages. We were successful in quantifying and predicting a user's gender and age demographic. Similarly, we were able to predict different types of group usage. All models were built without analyzing message content. We present a detailed discussion about the specific attributes that were contained in all predictive models and suggest possible applications based on these results. *

Hyperthyroidism has been reported to affect all of the major determinants of left ventricular performance in a manner that would augment ventricular shortening characteristics. The hypothesis tested in this study is that reduced afterload in conjunction with increased preload and heart rate, rather than augmented contractility, accounts for much of the increase in left ventricular performance noted previously in these patients. To investigate this hypothesis, 11 hyperthyroid patients were evaluated serially over 4 +/- 2 months. With therapy, serum total thyroxin (T4) decreased significantly (p less than 0.001). Ventricular hemodynamics were assessed by two-dimensional targeted M-mode echocardiograms and calibrated carotid pulse tracings. Ventricular preload was estimated by end-diastolic dimension, whereas afterload was measured as end-systolic wall stress. Overall left ventricular performance was quantitated by the extent and velocity of shortening, whereas myocardial work was assessed by ventricular systolic stress-length relations. With therapy, overall left ventricular performance declined (p less than 0.01). This change was associated with no change in end-diastolic dimension or end-systolic wall stress, and a 24% fall in heart rate (p less than 0.01). This latter finding has been shown previously to have no significant effect on left ventricular contractile state over the range of heart rates encountered in this study. In all cases, the end-systolic stress/rate-corrected shortening velocity relation fell with attainment of normal thyroid status, characteristic of a decline in contractility. There was a strong positive correlation between left ventricular contractility and serum thyroid hormone level (r = 0.83). In addition, ventricular minute work declined with therapy (p less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)