The use of Omiderm, a new skin substitute, in a burn unit

Cristofoli, Cesare; Lorenzini, M.; Furlan, S

doi:10.1016/0305-4179(86)90010-0

Cited by 26 publications

(5 citation statements)

References 6 publications

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“…6 The ideal burn dressing would be nontoxic, nonantigenic, and nonadherent, have mechanical strength to maintain a barrier function, be impermeable to bacteria, allow adequate water-vapor transmission, conform to body surfaces, be permeable to oxygen and carbon dioxide, have absorptive capacity, and be compatible with topical therapeutic agents. 7 While many burn dressings are currently available, [8][9][10][11][12][13][14][15][16][17][18][19][20][21] none are ideal. To date, silver sulfadiazine (SSD) 1% cream is the most commonly used local treatment for burns.…”

mentioning

confidence: 99%

Octylcyanoacrylate for the Treatment of Partial‐thickness Burns in Swine: A Randomized, Controlled Experiment

Singer

Berrutti

Thode

et al. 1999

Academic Emergency Medicine

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Abstract. Objective: To compare re-epithelialization rates of superficial partial-thickness burns treated with octylcyanoacrylate (OCA), silver sulfadiazine (SSD), and dry gauze (controls) in swine. Methods: This was a prospective, longitudinal, blinded, controlled, experimental trial using anesthetized swine. Sixty-three standardized burns were created by applying an aluminum bar preheated to 80 o C for 20 seconds to the flanks of four young pigs. Three equal sets of 21 burns were randomly treated with OCA spray, SSD, or dry gauze (controls). Full-thickness biopsies were taken after 30 minutes and at seven and 14 days for blinded histopathologic evaluation by two dermatopathologists using hematoxylin and eosin staining. The percent of wound re-epithelialization was measured at days 7 and 14, calculated by dividing the length of the regenerated epidermis by the measured width of the biopsy. Analysis of variance (ANOVA) and repeated-measures ANOVA controlling for the individual pig were used for comparisons among groups. This study had 80% power to demonstrate a large between-group difference in percent re-epithelization (alpha = 0.05). Results: There were 63 burns and 126 biopsies. Ten biopsies were excluded for technical reasons. At seven days, there was a significant between-group difference in percent re-epithelialization. Percent re-epithelialization was greatest in the OCA group (65.0%), followed by the SSD group (37.6%), and lowest in the control group (8.8%). At 14 days, all wounds demonstrated near complete re-epithelialization and there was no significant difference in the percent of re-epithelialization among the groups. There was only one wound infection in the OCA group. Conclusions: Under these study conditions, treatment of partial-thickness burns with OCA spray resulted in a higher percent of re-epithelialization at seven but not 14 days when compared with both SSD and control, with no significant increase in infection rates. Future studies should evaluate the use of OCA for the treatment of burns in humans.

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confidence: 99%

Octylcyanoacrylate for the Treatment of Partial‐thickness Burns in Swine: A Randomized, Controlled Experiment

Singer

Berrutti

Thode

et al. 1999

Academic Emergency Medicine

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“…The membrane is impermeable to biologic particles such as blood cells, other cellular debris, and high‐molecular‐weight fluids 7 . This has created problems with blood accumulation following escharectomy, 4 skin graft donor sites, 1 and, in our studies, dermabrasion. In response to these problems with extremely exudative and/or bloody acute wounds, Omikron made a meshed membrane available during early 1988.…”

Section: Omiderm—physical Propertiesmentioning

confidence: 77%

“…The membrane's high permeability rate makes it suitable for wounds that exude large amounts of liquids (especially during the primary stages of treatment), such as the following: burns; dermabrasions; split‐thickness skin graft donor sites; heavily exuding skin ulcers; and various skin diseases (toxic epidermal necrolysis, pemphigous vulgaris, epidermolysis bullosa, etc.). Even with a water permeability several times that of most other occlusive dressings, occasional cases of excess accumulation of fluids have been reported when the membrane was used for burns 4–6 . The membrane is impermeable to biologic particles such as blood cells, other cellular debris, and high‐molecular‐weight fluids 7 .…”

Section: Omiderm—physical Propertiesmentioning

confidence: 80%

A New Hydrophilic Copolymer Membrane for Dermabrasion

Raab

1991

The Journal of Dermatologic Surgery and Oncology

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“…For example, Biobrane s and Omiderm s are suitable to provoke a complete epithelisation within 2 weeks after application to superficial dermal lesions [1,3,4,10,14]. But areas of deep dermal and indeterminate depth burns will become infected regularly.…”

Section: Introductionmentioning

confidence: 98%

“…Accordingly, the average ABSI was 7.9 in group A and 5.7 in group B. Nevertheless, the patient with the highest TBSA (95 %, ABSI 13) belonged to group B (Figs [1][2][3][4][5]…”

mentioning

confidence: 99%

Actual Strategies in the Treatment of Severe Burns - Considering Modern Skin Substitutes

Uhlig¹,

Hierlemann²,

Dittel³

2007

Osteo trauma care

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Early wound closure enables a better prognosis with regard to survival and outcome in severe burn injuries. Even so, the treatment of extended 2 nd degree thermal traumas is well discussed. A conservative procedure with daily changes of dressings and application of topical antimicrobial creams is uncomfortable for patients and staff. In addition, there is a higher risk of severe infection. Meanwhile, early debridement and temporary wound coverage is established as state of the art also in 2 nd degree burns. Many biological and textile materials are already in use. The newly designed resorbable polylactide-membrane Suprathel s seems to be a good alternative material. We have proved that Suprathel s significantly reduces pain. The handling of Suprathel s is very easy. This retrospective study of our patients with severe thermal injuries shows that primarily the majority of burn victims were treated with Suprathel s . Only few patients required an additional grafting even in cases with extended burn areas. The frequency of grafting procedures could be reduced considerably. But also patients with extended 3 rd degree burn areas requiring an early skin grafting had a benefit from the application of Suprathel s on donor sites and all tangential necrotic areas. Encouraged by this success, we established a new two-step concept for the treatment of severe thermal injuries. This strategy seems to be suitable also for burn centres with low financial resources, because expensive tissue engineering therapies are reduced to a minimum by this concept. Key wordsSevere thermal injuries Á early wound closure Á temporary skin substitutes Á resorbable polylactide membrane Á Suprathel s Á retrospective study Á new strategy for treatment Affiliation

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The use of Omiderm, a new skin substitute, in a burn unit

Cited by 26 publications

References 6 publications

Octylcyanoacrylate for the Treatment of Partial‐thickness Burns in Swine: A Randomized, Controlled Experiment

Octylcyanoacrylate for the Treatment of Partial‐thickness Burns in Swine: A Randomized, Controlled Experiment

A New Hydrophilic Copolymer Membrane for Dermabrasion

Actual Strategies in the Treatment of Severe Burns - Considering Modern Skin Substitutes

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