The Use of N-Terminal-Pro-BNP in Preterm Infants

El‐Khuffash, Afif; Molloy, Eleanor J.

doi:10.1155/2009/175216

Cited by 27 publications

(26 citation statements)

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“…In another study by S. Mannarino et al the amount of BNP was tested in the umbilical cord of term and preterm infants. Also a greater increase was observed in BNP level of preterm infants in comparison with the term cases (25). In another study, Remzi Kardag et al demonstrated relationships between intracellular pressure and natriuretic peptide, in the plasma of patients with hypothyroidism conditions.…”

Section: Discussionmentioning

confidence: 89%

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Brain Natriuretic Peptide: A Predictor for Severity Respiratory Distress Syndrome in Newborns

et al. 2013

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Background:Respiratory distress syndrome (RDS) is considered as one of the most popular prematurity-related respiratory problems and among the most prominent reasons of deaths in preterm infants. Objectives: Brain Natriuretic Peptide (BNP) is the secret of the volume and pressure overload response of the vessels and decreases due to resistance as well as rises in systemic vessels and also in decline of pulmonary artery pressure. In the present paper, BNP is considered as a biomarker for prediction of RDS scoring. Materials and Methods: In this case, 65 preterm infants under 37 weeks with an Apgar score more than seven and 65 healthy term infants were chosen. All of them were controlled for three days in NICU and then divided into 4 groups based on the RDS scoring and intensity, as well as chest x-ray findings; normal, mild, moderate, and severe. Serum BNP of all the infants was measured through ELISA kit and a questionnaire was filled up for each infant based on his/her demographic information and clinical findings. The collected data were analyzed by SPSS software based on the independent statistical t-test, one-sided variance analysis and X2. P < 0.05 was considered as the significant. Results:The study results revealed a significant difference between the two groups regarding the pregnancy age, weight and type of delivery between cases and control groups (P ≥ 0.05); but there was no significant difference between BNP in cases and control groups (P ≤ 0.05). However, the comparison between the mean of pregnancy weight, pregnancy age, and BNP based on RDS frequency among the patients was significant (P ≥ 0.05). Conclusions:The results of this study demonstrated that serum BNP level correlates with increased RDS scoring. Therefore, it is possible to use BNP as the prediction marker for the progressive changes of RDS which occur in premature infants.

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Section: Discussionmentioning

confidence: 89%

“…In a study by Gustavo Rocha et al there was a relationship between BNP serum levels in premature infants with respiratory distress syndrome (RDS) (25). In another study by Joseph et al increase in BNP serum level was demonstrated as a marker for recognition of BPD in prematurity.…”

Section: Discussionmentioning

confidence: 97%

Brain Natriuretic Peptide: A Predictor for Severity Respiratory Distress Syndrome in Newborns

et al. 2013

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“…BNP levels have also been shown to transiently increase in preeclampsia, with normalization after delivery [10]. In children, BNP levels have been studied in the setting of congenital heart disease [3] and patent ductus arteriosus (PDA) [11], as well as persistent pulmonary hypertension of the newborn (PPHN) [4]. Serum BNP levels are significantly increased in patients with hemodynamically symptomatic PDA requiring indomethacin administration and/or surgical ligation compared to those with asymptomatic PDA [12].…”

Section: Discussionmentioning

confidence: 99%

Brain-type natriuretic peptide levels correlate with pulmonary hypertension and requirement for extracorporeal membrane oxygenation in congenital diaphragmatic hernia

Partridge

Hanna

Rintoul

et al. 2015

Journal of Pediatric Surgery

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“…ElKhuffash et al (5) reported that BNP level was affected by PDA diameter and LA/Ao ratio after the 12 th hour after birth and with the increase in both of these values BNP increased significantly in the review they published about BNP in preterm babies. These results in the literature are compatible with our study.…”

Section: Discussionmentioning

confidence: 99%

“…Brain natriuretic peptide is a polypeptide consisting of 32 amino acids and a hormone released from the ventricles of the heart in case of hemodynamic stress and congestive heart failure (4)(5)(6). BNP which is released from the ventricles as a response to increased ventricular volume load is a cardiac marker which is convenient for use for urgent diagnosis, since it is produced rapidly at high levels in cases of congestive heart failure, left ventricular dysfunction and increase of pressure and volume load in the left and right ventricles.…”

Section: Introductionmentioning

confidence: 99%

Erken doğmuş bebeklerde beyin natriüretik peptit düzeyi ile patent duktus arteriyozus arasındaki ilişki

...

2012

Tpa

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Aim: To compare brain natriuretic peptide level and some of the echocardiographic parameters of premature infants and to search its value for the diagnosis of patent ductus arteriosus. Patients with patent ductus arteriosus constituted Group 1 (n=20) and patients without patent ductus arteriosus constituted Group 2 (n=30). The diagnosis of patent ductus arteriosus was made by M-mode and Doppler echocardiography on the 7 th day postnatally. Ductus diameter, left atrium aortic root diameter ratio, left ventricular end diastolic diameter, interventricular septum thickness, left ventricular posterior wall thickness, ejection fraction and fractional shortening were evaluated. The infants with hemodynamically significant patent ductus arteriosus were treated. Brain natriuretic peptide was evaluated on the 1 st , 3 rd and 7 th days of postnatal age in all patients and also on the 3 rd day after treatment. For statistical analysis SPSS for Windows 15.0 was used. The study was conducted after obtaining informed consent from the patients and was approved with the decision of the ethics committee (number 231, date 12-6-2009). Results: Sex, gestational age and birth weight were similar in both grups. When brain natriuretic peptide level was compared with ductus diameter, left atrium aortic root diameter ratio and left ventricular end diastolic diameter values, the results were found to be statistically significant (p<0.05). When comparison was made with interventricular septum thickness, left ventricular posterior wall thickness, ejection fraction and fractional shortening values, the results were found to be statistically insignificant (p>0.05). Brain natriuretic peptide level decreased significantly after treatment. Conclusions: Brain natriuretic peptide level was found be higher in infants with patent ductus arteriosus compared to infants without patent ductus arteriosus. It was shown that ductus diameter, left atrium aortic root diameter ratio and left ventricular end diastolic diameter were related with brain natriuretic peptide levels. (Turk Arch Ped 2012; 47: 92-6) Key words: Patent ductus arteriosus, brain natriuretic peptide, premature infant, echocardiography, atrial natriuretic peptide, left atrium aortic root diameter ratio, left ventricular end diastolic diameter.

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The Use of N-Terminal-Pro-BNP in Preterm Infants

Cited by 27 publications

References 50 publications

Brain Natriuretic Peptide: A Predictor for Severity Respiratory Distress Syndrome in Newborns

Brain Natriuretic Peptide: A Predictor for Severity Respiratory Distress Syndrome in Newborns

Brain-type natriuretic peptide levels correlate with pulmonary hypertension and requirement for extracorporeal membrane oxygenation in congenital diaphragmatic hernia

Erken doğmuş bebeklerde beyin natriüretik peptit düzeyi ile patent duktus arteriyozus arasındaki ilişki

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