Erken doğmuş bebeklerde beyin natriüretik peptit düzeyi ile patent duktus arteriyozus arasındaki ilişki

Abstract

Aim: To compare brain natriuretic peptide level and some of the echocardiographic parameters of premature infants and to search its value for the diagnosis of patent ductus arteriosus. Patients with patent ductus arteriosus constituted Group 1 (n=20) and patients without patent ductus arteriosus constituted Group 2 (n=30). The diagnosis of patent ductus arteriosus was made by M-mode and Doppler echocardiography on the 7 th day postnatally. Ductus diameter, left atrium aortic root diameter ratio, left ventricular end diastolic diameter, interventricular septum thickness, left ventricular posterior wall thickness, ejection fraction and fractional shortening were evaluated. The infants with hemodynamically significant patent ductus arteriosus were treated. Brain natriuretic peptide was evaluated on the 1 st , 3 rd and 7 th days of postnatal age in all patients and also on the 3 rd day after treatment. For statistical analysis SPSS for Windows 15.0 was used. The study was conducted after obtaining informed consent from the patients and was approved with the decision of the ethics committee (number 231, date 12-6-2009). Results: Sex, gestational age and birth weight were similar in both grups. When brain natriuretic peptide level was compared with ductus diameter, left atrium aortic root diameter ratio and left ventricular end diastolic diameter values, the results were found to be statistically significant (p<0.05). When comparison was made with interventricular septum thickness, left ventricular posterior wall thickness, ejection fraction and fractional shortening values, the results were found to be statistically insignificant (p>0.05). Brain natriuretic peptide level decreased significantly after treatment. Conclusions: Brain natriuretic peptide level was found be higher in infants with patent ductus arteriosus compared to infants without patent ductus arteriosus. It was shown that ductus diameter, left atrium aortic root diameter ratio and left ventricular end diastolic diameter were related with brain natriuretic peptide levels. (Turk Arch Ped 2012; 47: 92-6) Key words: Patent ductus arteriosus, brain natriuretic peptide, premature infant, echocardiography, atrial natriuretic peptide, left atrium aortic root diameter ratio, left ventricular end diastolic diameter.