The European Organization for Nuclear Research (CERN) celebrates in October 2004 its 50 th anniversary. A centre of excellence for elementary particle physics research, the laboratory has contributed to the development of advanced technologies for the construction of powerful accelerators and experiments. As a follow-up of the article published by this journal in 1980, on the occasion of CERN's 25 th anniversary, this contribution describes the developments of particle detectors and experimental setups that took place in the laboratory during the last twenty-five years.