The use of MRI in the evaluation of myopathy

Lovitt, Steven; Moore, Sandra L.; Marden, Franklin A.

doi:10.1016/j.clinph.2005.10.010

Cited by 52 publications

(48 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As such, strong conclusions cannot be tifidus at C5, respectively. There was a significant difference between the fast (ADC b0-b50 ) and slow (ADC b50-b250 ) diffu- [ research report ] infiltration and denervation) 15,27 are present and widespread throughout the deep (multifidus and longus capitis/colli) and superficial (semispinalis and splenius capitis) neck muscles.…”

Section: Discussionmentioning

confidence: 99%

Diffusion-Weighted MRI for the Healthy Cervical Multifidus: A Potential Method for Studying Neck Muscle Physiology Following Spinal Trauma

Elliott

Pedler

Beattie

et al. 2010

J Orthop Sports Phys Ther

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Diffusion-Weighted MRI for the Healthy Cervical Multifidus: A Potential Method for Studying Neck Muscle Physiology Following Spinal Trauma

Elliott

Pedler

Beattie

et al. 2010

J Orthop Sports Phys Ther

View full text Add to dashboard Cite

“…This depends on different relaxation times: transversal (T1) and longitudinal (T2) relaxation time (for further information see Pipe, 1999or Hodgson, 2010. Depending on the used sequence weighting, different pathologic conditions can be visualized and result in areas (volumes) with increased signal intensity (Lovitt et al, 2006;May et al, 2000;Schrank et al, 2005). For this study, T1-and T2-weighted spin echo sequences with two directions of acquisition (axial and coronary; only results for the coronary acquisition are displayed) were applied (see Tab.…”

Section: Magnetic Resonance Imagingmentioning

confidence: 99%

“…Muscle signal intensity can be affected by various conditions such as trauma, infection or inflammation. These abnormalities effect an alteration in tissue parameters and cause differences in signal intensity in the image, as well as in muscle size and profile (Lovitt et al, 2006;May et al, 2000;Schrank et al, 2005). The ability to detect these alterations makes MRI a useful tool in diagnosis and follow-up of musculoskeletal diseases in humans (Lovitt et al, 2006;Messineo et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

“…In human medicine imaging methods like MRI, computer tomography (CT) and ultrasound (US) are approved methods for clinical studies of muscular disorders like inflammation, denervation, mass lesions and their follow-up (Kuo and Carrino, 2007;Reimers, 1990;Schedel et al, 1992;Walker, 2008). Because of its higher sensitivity, a better contrast resolution and the use of non-ionizing radiation, MRI became the method of choice for soft tissue imaging (Fisher et al, 1986;Lovitt et al, 2006;Nägele and Hahn, 1990;Tanttu and Sepponen, 1996).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Safety testing of veterinary vaccines using magnetic resonance imaging in pigs

Bernau

Kremer

Pappenberger

et al. 2015

ALTEX

View full text Add to dashboard Cite

SummarySafety testing of veterinary vaccines requires the use of a large number of animals to investigate possible local and systemic reactions. This includes, among others, the pathological examination of the injection site in frequent intervals. This examination requires a selected killing of animals in frequent intervals. To reduce the number of animals needed for this kind of safety testing, magnetic resonance imaging (MRI) was used to detect and quantify possible local reactions after vaccination in vivo. Sixty-four pigs were divided into four experimental groups (n = 16); two groups consisting of 12-week-old pigs and two of 6-month-old pigs at vaccination day. The pigs were vaccinated with four licensed products (each group receiving one vaccine) and examined up to 6 times using MRI during a period of 5 weeks. The MR images were evaluated semi-automatically, comparing the volumes of altered signal intensities on the vaccination side (VS) with the volumes of the signal intensities on the control side (CS). A paired t-test was used to identify significant differences (p < 0.05) between VS and CS. The results show that MRI allows a 3D-quantification of the extent of local reactions in vivo by scanning the same live animals at several time points after vaccination. MRI is a suitable alternative method for non-invasive safety testing of injectable medicines and can therefore be applied to reduce animal numbers used for safety testing purposes.

show abstract

“…However, the direction of the association between PPT_local, TF (P = 0.09) and TUF (P = 0.1) was inverse (e.g., those with higher fat content had higher thresholds) and this is more difficult to explain. Nevertheless, the results of this study might provide some preliminary evidence that the presence of cold and widespread mechanical hyperalgesia in conjunction with the MRI findings of muscular fatty infiltrate in the upper cervical musculature could be reflective of a peripheral nerve injury in the cervical region [8,18,21,35,36,63] and could explain the widespread sensory findings in this cohort. The presence of these sensory features in conjunction with the temporal development and magnitude of fatty infiltrate needs to be investigated in a prospective, longitudinal study with a more heterogeneous population to better identify a possible neuropathic [3,24] element in at least some patients who transition to chronicity.…”

Section: Discussionmentioning

confidence: 86%

The clinical presentation of chronic whiplash and the relationship to findings of MRI fatty infiltrates in the cervical extensor musculature: a preliminary investigation

et al. 2009

View full text Add to dashboard Cite

The objective was to determine whether any measurable changes in sensory responses, kinesthetic sense, cervical motion, and psychological features were related to established fatty infiltration values in the cervical extensor musculature in subjects with persistent whiplash. It is unknown if fatty infiltrate is related to any signs or symptoms. Data on motor function, Quantitative Sensory Testing, psychological and general well-being, and pain and disability were collected from 79 female subjects with chronic whiplash. Total fat values were created for all subjects by averaging the muscle fat indices by muscle, level, and side from our MRI dataset of all the cervical extensor muscles. Results of this study indicate the presence of altered physical, kinesthetic, sensory, and psychological features in this cohort of patients with chronic whiplash. Combined factors of sensory, physical, kinesthetic, and psychological features all contributed to a small extent in explaining the varying levels of fatty infiltrate, with cold pain thresholds having the most influence (r 2 = 0.28; P = 0.02). Identifying and relating quantifiable muscular alterations to clinical measures in the chronic state, underpin some clinical hypotheses for possible pathophysiological processes in this group with a chronic and recalcitrant whiplash disorder. Future research investigations aimed at accurate identification, sub-classification, prediction, and management of patients with acute and chronic whiplash is warranted and underway.

show abstract

The use of MRI in the evaluation of myopathy

Cited by 52 publications

References 39 publications

Diffusion-Weighted MRI for the Healthy Cervical Multifidus: A Potential Method for Studying Neck Muscle Physiology Following Spinal Trauma

Diffusion-Weighted MRI for the Healthy Cervical Multifidus: A Potential Method for Studying Neck Muscle Physiology Following Spinal Trauma

Safety testing of veterinary vaccines using magnetic resonance imaging in pigs

The clinical presentation of chronic whiplash and the relationship to findings of MRI fatty infiltrates in the cervical extensor musculature: a preliminary investigation

Contact Info

Product

Resources

About