The Use of Micro- and Nanospheres as Functional Components for Bone Tissue Regeneration

Wang, Huanan; Leeuwenburgh, Sander C. G.; Li, Yubao; Jansen, John A.

doi:10.1089/ten.teb.2011.0184

Cited by 158 publications

(114 citation statements)

References 172 publications

(225 reference statements)

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“…Biodegradable microspheres have been used as cell carriers with injectability, controllable biodegradability and capacity for drug incorporation [67]. Compared with hydrogel-based injectable carriers, microspheres could provide sufficient anchorages and better facilitate cell attachment for anchorage-dependent cells.…”

Section: Injectable Microspheres For Tissue Engineeringmentioning

confidence: 99%

“…Thus, the combination of microspheres with cells ex vivo prior to implantation can lead to enhanced tissue regeneration. Other polymers could also be blended with poly(α-hydroxy acids) to fabricate microcarriers for cells [67,[113][114]. Other synthetic injectable platforms include polycaprolactone particles featuring cell-adhesive polydopamine for human neural stem cell attachment [115].…”

Section: Injectable Microspheres For Tissue Engineeringmentioning

confidence: 99%

“…As one example, calcium carbonate microspheres were found to stimulate mineralization and MSC differentiation in vitro and enhanced bone formation in vivo [121]. However, the fabrication of inorganic matters into a spherical shape is challenging, and often requires the incorporation of a polymer phase that subsequently needs to be removed after the spheres formation [67].…”

Section: Injectable Microspheres For Tissue Engineeringmentioning

confidence: 99%

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Nanostructured injectable cell microcarriers for tissue regeneration

2016

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Biodegradable polymer microspheres have emerged as cell carriers for the regeneration and repair of irregularly shaped tissue defects due to their injectability, controllable biodegradability and capacity for drug incorporation and release. Notably, recent advances in nanotechnology allowed the manipulation of the physical and chemical properties of the microspheres at the nanoscale, creating nanostructured microspheres mimicking the composition and/or structure of natural extracellular matrix. These nanostructured microspheres, including nanocomposite microspheres and nanofibrous microspheres, have been employed as cell carriers for tissue regeneration. They enhance cell attachment and proliferation, promote positive cell-carrier interactions and facilitate stem cell differentiation for target tissue regeneration. This review highlights the recent advances in nanostructured microspheres that are employed as injectable, biomimetic and cell-instructive cell carriers.

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Section: Injectable Microspheres For Tissue Engineeringmentioning

confidence: 99%

Section: Injectable Microspheres For Tissue Engineeringmentioning

confidence: 99%

Section: Injectable Microspheres For Tissue Engineeringmentioning

confidence: 99%

See 1 more Smart Citation

Nanostructured injectable cell microcarriers for tissue regeneration

2016

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“…1 To this end, they can affect physicochemical and biological characteristics, in terms of porosity, 2 mechanical properties, 2 biodegradation, 3 the release kinetics of bioactive agents, 4 and bioactivity. 3 One of the greatest advantages of introducing MS into a bulk matrix is to allow final composite scaffolds controlled delivery of biomolecules in a spatiotemporal manner.…”

Section: Introductionmentioning

confidence: 99%

“…7 Third, a composite system of MS-embedding CPC was researched extensively to solve the major drawbacks of CPC: slow degradation rate attributed to a lack of macroporosity and poor drug-release capacity. 1 In this regard, many types of biodegradable polymeric MSs were homogeneously incorporated into bone cements, not only to facilitate in vitro/in vivo biodegradation and the resultant formation of well-interconnected macroporous structures, but also, to obtain the controlled release of bioactive agents for a prolonged period of time, without an initial drug burst. [9][10][11] In our previous studies, we developed a novel roomtemperature process of three-dimensional (3D) magnesium phosphate (MgP) scaffold fabrication, using a paste-extruding deposition (PED) system.…”

Section: Introductionmentioning

confidence: 99%

Effect of hydroxyapatite-containing microspheres embedded into three-dimensional magnesium phosphate scaffolds on the controlled release of lysozyme and in vitro biodegradation

Lee¹,

Yun²

2014

IJN

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The functionality of porous three-dimensional (3D) magnesium phosphate (MgP) scaffold was investigated for the development of a novel protein delivery system and biomimetic bone tissue engineering scaffold. This enhancement can be achieved by incorporation of hydroxyapatite (HA)-containing polymeric microspheres (MSs) into a bulk MgP matrix, and a paste-extruding deposition (PED) system. In this work, the amount of MS and HA was precisely controlled when manufacturing MS-embedded MgP (MS/MgP) composite scaffolds. The main influence was researched in terms of in vitro lysozyme-release, in vitro biodegradation, mechanical properties, and in vitro calcification. The controlled release of lysozyme was indicated, while showing graded release patterns according to HA content. The composite scaffolds degraded gradually with MS content and degradation time. Due to the effect of HA inclusion, the higher HA-containing MS/MgP scaffolds could, not only delay the biodegradation process but also, compensate for the possible loss of mechanical properties. In this regard, it is reasonable to confirm the inverse relationship between biodegradation and corresponding compressive properties. In order to encourage bioactivity and osteoconductivity, the MS/MgP composite scaffolds were subjected to simulated body fluid treatment. Calcium deposition was, in turn, improved with increasing MS and HA content over time. This quantitative result was also proved using morphological and elemental analysis. In summary, a significant transformation of a monolithic MgP scaffold was directed toward a multifunctional bone tissue engineering scaffold equipped with controlled protein delivery, biodegradability, and bioactivity.

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Research Progress on Injectable Microspheres as New Strategies for the Treatment of Osteoarthritis Through Promotion of Cartilage Repair

Lin,

Jia,

Cao

et al. 2024

Adv Funct Materials

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Osteoarthritis (OA) is a degenerative disease caused by a variety of factors with joint pain as the main symptom, including fibrosis, chapping, ulcers, and loss of cartilage. Traditional treatment can only delay the progression of OA, and classical delivery system have many side effects. In recent years, microspheres have shown great application prospects in the field of OA treatment. Microspheres can support cells, reproduce the natural tissue microenvironment in vitro and in vivo, and are an efficient delivery system for the release of drugs or biological agents, which can promote cell proliferation, migration, and differentiation. Thus, they have been widely used in cartilage repair and regeneration. In this review, preparation processes, basic materials, and functional characteristics of various microspheres commonly used in OA treatment are systematically reviewed. Then it is introduced surface modification strategies that can improve the biological properties of microspheres and discussed a series of applications of microsphere functionalized scaffolds in OA treatment. Finally, based on bibliometrics research, the research development, future potential, and possible research hotspots of microspheres in the field of OA therapy is systematically and dynamically evaluated. The comprehensive and systematic review will bring new understanding to the field of microsphere treatment of OA.

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The Use of Micro- and Nanospheres as Functional Components for Bone Tissue Regeneration

Cited by 158 publications

References 172 publications

Nanostructured injectable cell microcarriers for tissue regeneration

Nanostructured injectable cell microcarriers for tissue regeneration

Effect of hydroxyapatite-containing microspheres embedded into three-dimensional magnesium phosphate scaffolds on the controlled release of lysozyme and in vitro biodegradation

Research Progress on Injectable Microspheres as New Strategies for the Treatment of Osteoarthritis Through Promotion of Cartilage Repair

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The Use of Micro- and Nanospheres as Functional Components for Bone Tissue Regeneration

Cited by 158 publications

References 172 publications

Nanostructured injectable cell microcarriers for tissue regeneration

Nanostructured injectable cell microcarriers for tissue regeneration

Effect of hydroxyapatite-containing microspheres embedded into three-dimensional magnesium phosphate scaffolds on the controlled release of&nbsp;lysozyme and in vitro biodegradation

Research Progress on Injectable Microspheres as New Strategies for the Treatment of Osteoarthritis Through Promotion of Cartilage Repair

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Effect of hydroxyapatite-containing microspheres embedded into three-dimensional magnesium phosphate scaffolds on the controlled release of lysozyme and in vitro biodegradation