The Use of Melatonin as an Alternative to Sedation in Uncooperative Children Undergoing an MRI Examination

Johnson, Karl; Page, Anthony; Williams, Helen; Wassemer, E.; Whitehouse, William P

doi:10.1053/crad.2001.0923

Cited by 81 publications

(87 citation statements)

References 22 publications

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“…Melatonin has previously been successfully utilised as an alternative to sedation in children undergoing magnetic resonance imaging examinations (MRI), as conventional sedation methods and/or general anaesthetic propose high failure rates as well as risk factors for this population. 22,15 The results of this study indicated that 65 % of the children who received melatonin fell asleep within 35 minutes of receiving the drug; and findings of this study also highlighted the positive outcomes of using melatonin, in terms of cost, age, patient safety and resuscitation facilities and equipment; which are factors associated with conventional sedation methods and/or general anaesthetic. 22 Some studies have reported the use of melatonin in combination with sedatives when sedating children undergoing MRI examinations.…”

Section: Introductionmentioning

confidence: 61%

“…22,15 The results of this study indicated that 65 % of the children who received melatonin fell asleep within 35 minutes of receiving the drug; and findings of this study also highlighted the positive outcomes of using melatonin, in terms of cost, age, patient safety and resuscitation facilities and equipment; which are factors associated with conventional sedation methods and/or general anaesthetic. 22 Some studies have reported the use of melatonin in combination with sedatives when sedating children undergoing MRI examinations. 23 Depending on their weight, the children were either provided with 3 or 6 mg of melatonin ten minutes prior to sedation.…”

Section: Introductionmentioning

confidence: 61%

“…For example, in a similar study, children with suspected hearing loss were provided with between 5 mg and 20 mg of melatonin; depending on their age, and the testing began once each child had begun sleeping. 8 In another study also on children 10 mg of melatonin was administered 30 minutes prior to the initiation of the testing procedure 22 granted that these were for different procedures. Although it has been reported that adults can be safely provided with 50 mg of melatonin 13 the current study indicated that 3 mg 40 minutes prior to the ABR testing can be just as effective.…”

Section: Muscle Artifacts Of the Abr Recordingsmentioning

confidence: 99%

“…Nonetheless, the current authors are of the view that an extension of the findings to the pediatric population can possibly be supported by earlier reports on successful use of Melatonin as an alternative to sedation in children undergoing MRI. 15,22 The consequent benefits for patients, particularly from contexts where resources are limited, are significant. Patients would not need to be admitted as inpatients and pay for additional resources just to undergo an audiologic evaluation.…”

Section: Conclusion and Recommendationsmentioning

confidence: 99%

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The Use of Melatonin for Sedation During Auditory Brainstem Response Testing: An Alternative to Sedation in Non-Medical Settings?

Shangase¹,

Mavrokordatos²

2013

J Pharm Sci Innov.

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The audiological use of the auditory brainstem response (ABR) to obtain diagnostic audiological information can be challenging in the "difficult-to-test" populations where sedation is required. This challenge becomes more pronounced in non-medical settings where medical personnel who can provide drug administration as well as monitor the patient while under sedation are not readily available. The non-medical setting comprises a big portion of audiology practices and clinics; hence the importance of exploring sedation protocols that can be used in this setting. The current study explored the use of melatonin as a "sedative" during ABR testing. Within a prospective pretest -posttest design, 27 adults with normal hearing comprised the study sample. All participants underwent basic audiologic testing comprising of otoscopy, tympanometry, and pure tone audiometry followed by an ABR which was conducted pre and post melatonin administration. The initial recording was conducted prior to the administration of melatonin with the second recording performed 40 minutes following the participants' intake of 3 milligrams of melatonin. Data was analysed using both qualitative and quantitative statistical measures. Findings indicated that melatonin can be successfully utilised as a * "sedative" during ABR testing as it allowed for statistically significant reduction in muscle artifacts, did not present negative impact on morphology, repeatability, amplitude and latency of the recordings; and also did not induce any obvious and/or reported negative effects for the participants. These findings have important clinical and training implications, particularly in resource-constrained contexts and in contexts where audiologists function within non-medical facilities.

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Section: Introductionmentioning

confidence: 61%

Section: Introductionmentioning

confidence: 61%

Section: Muscle Artifacts Of the Abr Recordingsmentioning

confidence: 99%

Section: Conclusion and Recommendationsmentioning

confidence: 99%

See 2 more Smart Citations

The Use of Melatonin for Sedation During Auditory Brainstem Response Testing: An Alternative to Sedation in Non-Medical Settings?

Shangase¹,

Mavrokordatos²

2013

J Pharm Sci Innov.

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“…Wegen seiner antinozizeptiven Effekte und der Senkung des Verbrauchs von Propofol und Thiopental könnte es auch perspektivisch zur Narkose eingesetzt werden [27]. Klinisch wird es teilweise zur Schlafinduktion bei Kindern im Zusammenhang mit diagnostischen Prozeduren (Computertomographie; MRT; "brainstem electric response audiometry", BERA) eingesetzt [19,42]. Problematisch bleiben die relative schlechte Steuerbarkeit und ein hoher Anteil von Patienten, die nicht oder nicht ausreichend einschlafen.…”

Section: Verbesserungsmöglichkeitenunclassified

Funktionelle Topodiagnostik der oberen Atemwege bei schlafbezogenen Atmungsstörungen

et al. 2009

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The potential utility of melatonin in the treatment of childhood cancer

Chao

Yeh

et al. 2019

Journal Cellular Physiology

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Childhood cancer management has improved considerably, with the overall objective of preventing early-life cancers completely. However, cancer remains a major cause of death in children, with the survivors developing anticancer treatment-specific health problems. Therefore, the anticancer treatment needs further improvement.Melatonin is a effective antioxidant and circadian pacemaker. Through multiple mechanisms, melatonin has significant positive effects on multitude adult cancers by increasing survival and treatment response rates, and slowing disease progression. In addition, melatonin appears to be safe for children. As an appealing therapeutic agent, we herein address several key concerns regarding melatonin's potential for treating children with cancer.

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The Use of Melatonin as an Alternative to Sedation in Uncooperative Children Undergoing an MRI Examination

Cited by 81 publications

References 22 publications

The Use of Melatonin for Sedation During Auditory Brainstem Response Testing: An Alternative to Sedation in Non-Medical Settings?

The Use of Melatonin for Sedation During Auditory Brainstem Response Testing: An Alternative to Sedation in Non-Medical Settings?

Funktionelle Topodiagnostik der oberen Atemwege bei schlafbezogenen Atmungsstörungen

The potential utility of melatonin in the treatment of childhood cancer

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