The use of MatriDerm® and skin grafting in post-traumatic wounds

Cervelli, Valerio; Brinci, Lorenzo; Spallone, Diana; Tati, Eleonora; Palla, Ludovico; Lucarini, Lucilla; Angelis, Bárbara De

doi:10.1111/j.1742-481x.2011.00806.x

Cited by 68 publications

(69 citation statements)

References 12 publications

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“…This process is complex and involves a variety of cells [1]. The dermis of the damaged skin is either replaced by scar tissue that epithelializes to form wound borders, or an STSG is used to close the wound.…”

Section: Introductionmentioning

confidence: 99%

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The Use of Matriderm and Autologous Skin Graft in the Treatment of Full Thickness Skin Defects

et al. 2014

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BackgroundFor patients with full thickness skin defects, autologous Split-thickness skin grafts (STSG) are generally regarded as the mainstay of treatment. However, skin grafts have some limitations, including undesirable outcomes resulting from scars, poor elasticity, and limitations in joint movement due to contractures. In this study, we present outcomes of Matriderm grafts used for various skin tissue defects whether it improves on these drawbacks.MethodsFrom January 2010 to March 2012, a retrospective review of patients who had undergone autologous STSG with Matriderm was performed. We assessed graft survival to evaluate the effectiveness of Matriderm. We also evaluated skin quality using a Cutometer, Corneometer, Tewameter, or Mexameter, approximately 12 months after surgery.ResultsA total of 31 patients underwent STSG with Matriderm during the study period. The success rate of skin grafting was 96.7%. The elasticity value of the portion on which Matriderm was applied was 0.765 (range, 0.635-0.800), the value of the trans-epidermal water loss (TEWL) was 10.0 (range, 8.15-11.00) g/hr/m2, and the humidification value was 24.0 (range, 15.5-30.0). The levels of erythema and melanin were 352.0 arbitrary unit (AU) (range, 299.25-402.75 AU) and 211.0 AU (range, 158.25-297.00 AU), respectively. When comparing the values of elasticity and TEWL of the skin treated with Matriderm to the values of the surrounding skin, there was no statistically significant difference between the groups.ConclusionsThe results of this study demonstrate that a dermal substitute (Matriderm) with STSG was adopted stably and with minimal complications. Furthermore, comparing Matriderm grafted skin to normal skin using Cutometer, Matriderm proved valuable in restoring skin elasticity and the skin barrier.

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Section: Introductionmentioning

confidence: 99%

“…As a result, STSG provides unsatisfactory results, such as scar contraction and scarring. In this process, reconstruction of the dermis plays an important role in the recovery of wounds, in particular [1,4,5]. …”

Section: Introductionmentioning

confidence: 99%

The Use of Matriderm and Autologous Skin Graft in the Treatment of Full Thickness Skin Defects

et al. 2014

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“…For the collagen-elastin membrane used in this study, the biocompatibility and biointegrity have well been proven [18,31,32]. The collagen-elastin scaffold forms a soft gelatinous layer when wet but proved to be stable enough to create a sleeve around the tendon suture site.…”

Section: Discussionmentioning

confidence: 96%

The effect of a collagen-elastin matrix on adhesion formation after flexor tendon repair in a rabbit model

Wichelhaus

Beyersdoerfer

Gierer

et al. 2016

Arch Orthop Trauma Surg

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“…24 However, its thickness is thin, only 1 mm; thus, it should be covered with split thickness skin grafts, causing morbidity of the donor site. [25][26][27][28][29] Furthermore, there are risks of allergic reaction and infection caused by bovine collagen. To overcome these challenges, alternative artificial scaffolds based on poly(ethylene glycol), poly(lactic acid), polycaprolactone, polyphosphates, ceramics and metals have been developed.…”

Section: Discussionmentioning

confidence: 99%

Development of Artificial Dermis Using 3D Electrospun Silk Fibroin Nanofiber Matrix

Oj¹,

Hw²,

Kim³

et al. 2014

Journal of Biomedical Nanotechnology

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Several auto- or alloplastic dermal substitutes have been used for full thickness skin defects. However, there is no ideal dermal substitute that is biocompatible and offers adequate mechanical properties and sufficient thickness and volume. Silk fibroin can be considered a possible alternative material for the construction of dermal substitutes. Nanofibers fabricated by electrospinning silk fibroin were considered an excellent candidate due to their desirable biocompatibility. However, it is generally difficult for cells to infiltrate the electrospun silk fibroin due to its small pore size. To overcome this challenge, a key parameter is the control of the pore size of silk fibroin electrospun such that cells can easily infiltrate into the nanofibers and proliferate internally. In this work, a novel approach is introduced by dropping two different size NaCl crystals above the rotating collector, which become incorporated into the nanofibers. The structures and properties of the, resulting electrospun silk fibroin were characterized using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), and its wound healing effect for a full thickness skin defect was compared with Matriderm. Although the dermal regenerative effect of the 3D-SF (3D electrospun silk fibroin nanofiber matrix) was similar to that of Matriderm, the 3D-SF was almost completely degraded and did not induce wound contracture like Matriderm. We suggest that 3D-SF can be applied to the treatment of full thickness skin defects.

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The use of MatriDerm® and skin grafting in post-traumatic wounds

Cited by 68 publications

References 12 publications

The Use of Matriderm and Autologous Skin Graft in the Treatment of Full Thickness Skin Defects

The Use of Matriderm and Autologous Skin Graft in the Treatment of Full Thickness Skin Defects

The effect of a collagen-elastin matrix on adhesion formation after flexor tendon repair in a rabbit model

Development of Artificial Dermis Using 3D Electrospun Silk Fibroin Nanofiber Matrix

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