The effect of a collagen-elastin matrix on adhesion formation after flexor tendon repair in a rabbit model

Wichelhaus, Dagmar Alice; Beyersdoerfer, Sascha Tobias; Gierer, Philip; Vollmar, Brigitte; Mittlmeier, Thomas

doi:10.1007/s00402-016-2472-2

Cited by 17 publications

(14 citation statements)

References 33 publications

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“…In recent years, biocompatible polymer scaffolds modified with proteins/peptides have been developed for regeneration of skin [192,202,203], nerves [204][205][206], muscles [207,208], tendons [209][210][211], cartilages [212][213][214], and bones [57,58,215]. To fabricate these biomaterials, many different techniques are applied.…”

Section: Application Of Polymer Scaffolds Modified With Proteins and mentioning

confidence: 99%

Proteins and Peptides as Important Modifiers of the Polymer Scaffolds for Tissue Engineering Applications—A Review

2020

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Polymer scaffolds constitute a very interesting strategy for tissue engineering. Even though they are generally non-toxic, in some cases, they may not provide suitable support for cell adhesion, proliferation, and differentiation, which decelerates tissue regeneration. To improve biological properties, scaffolds are frequently enriched with bioactive molecules, inter alia extracellular matrix proteins, adhesive peptides, growth factors, hormones, and cytokines. Although there are many papers describing synthesis and properties of polymer scaffolds enriched with proteins or peptides, few reviews comprehensively summarize these bioactive molecules. Thus, this review presents the current knowledge about the most important proteins and peptides used for modification of polymer scaffolds for tissue engineering. This paper also describes the influence of addition of proteins and peptides on physicochemical, mechanical, and biological properties of polymer scaffolds. Moreover, this article sums up the major applications of some biodegradable natural and synthetic polymer scaffolds modified with proteins and peptides, which have been developed within the past five years.

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Section: Application Of Polymer Scaffolds Modified With Proteins and mentioning

confidence: 99%

Proteins and Peptides as Important Modifiers of the Polymer Scaffolds for Tissue Engineering Applications—A Review

2020

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“…[12] Reduced postoperative adhesion was shown in another study where collagen-elastin matrix was used to prevent postoperative adhesion in an experimental rabbit model undergoing flexor tendon repair. [18] We did not find any study in the literature investigating the effect of MB on adhesion after chicken flexor tendon injury. We proposed that MB, particularly with its anti-inflammatory, antioxidant, antifibrotic effect, would both speed up the tendon healing process and reduce the adhesion that may occur in the postoperative period.…”

Section: Discussionmentioning

confidence: 85%

“…[ 16 , 17 ] Growth factors and cytokines were used for this purpose and skeletal structures were created from cells containing fibroblasts and these factors and cytokines were exogenously applied. [ 18 ] In an experimental study published in 2011, intraperitoneal MB solution treatments were more effective according to vitamin E in preventing the formation of intra- abdominal adhesion in a rat uterine horn model. [ 19 ]…”

Section: Discussionmentioning

confidence: 99%

Does methylene blue reduce adhesion during the healing process after tendon repair?

et al. 2020

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This study aims to biomechanically and histopathologically investigate the effects of methylene blue (MB) on preventing postoperative adhesion in chickens undergoing fullthickness flexor tendon incision. Materials and methods: This study was performed between June 2017 and June 2018 on Hubbard JA 57 type chickens (age, 6 months; weight, 2.2±0.3 kg). Sixty-four tendons were studied in 32 chickens, including 16 in the control group and 16 in the experimental group. The second and third finger flexor digitorum profundus tendons of the left foot of each chicken were repaired primarily after a full-thickness incision approximately 1 cm proximal to the distal adhesion area. In the control (n=32) and experimental groups (n=32), 0.25 mL of normal saline and 0.25 mL of 1% MB solutions were applied locally to the surgical site, respectively. The operated limb was immobilized using a circular cast. 16 chickens were randomly selected in each group and examined at the fourth week, and the remaining 16 chickens were examined at the sixth week. Thirty-two of these tendons were evaluated using the Tang histopathological adhesion classification system, and the other 32 were evaluated with a biomechanical pull system. Results: Adhesion was found to be less in the experimental group compared to the control group at the end of the fourth and sixth weeks both histopathologically and biomechanically. Furthermore, adhesion was significantly less in the experimental group at the end of the sixth week compared to the fourth week both histopathologically and biomechanically. Conclusion: Histopathological and biomechanical results show that MB, which has anti-inflammatory, antiseptic, antimicrobial and antioxidant effects, reduces adhesion during the healing process after tendon repair. We think that local MB application, particularly in surgeries performed after this type of injury, will be beneficial on early rehabilitation and functional results.

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“…Examples of such methods include nylon, silicon sheets, polyethylene membranes, as well as natural and polymeric membranes, and more recently, an adipo‐fascial flap . However, issues such as tendon necrosis, inflammation and fibrotic adhesion formation at the periphery of the barriers, were frequently encountered . The use of biological agents to prevent fibrosis have also been investigated.…”

Section: Introductionmentioning

confidence: 99%

“…[7][8][9][10][11][12][13] However, issues such as tendon necrosis, inflammation and fibrotic adhesion formation at the periphery of the barriers, were frequently encountered. 14 The use of biological agents to prevent fibrosis have also been investigated. Earlier efforts assessed agents such as fibrin, dextran and hyaluronic acid as approaches to prevent adhesion formation.…”

Section: Introductionmentioning

confidence: 99%

Influence of steel implant surface microtopography on soft and hard tissue integration

et al. 2017

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After implantation of an internal fracture fixation device, blood contacts the surface, followed by protein adsorption, resulting in either soft-tissue adhesion or matrix adhesion and mineralization. Without protein adsorption and cell adhesion under the presence of micro-motion, fibrous capsule formation can occur, often surrounding a liquid filled void at the implant-tissue interface. Clinically, fibrous capsule formation is more prevalent with electropolished stainless steel (EPSS) plates than with current commercially pure titanium (cpTi) plates. We hypothesize that this is due to lack of micro-discontinuities on the standard EPSS plates. To test our hypothesis, four EPSS experimental surfaces with varying microtopographies were produced and characterized for morphology using the scanning electron microscope, quantitative roughness analysis using laser profilometry and chemical analysis using X-ray photoelectron spectroscopy. Clinically used EPSS (smooth) and cpTi (microrough) were included as controls. Six plates of each type were randomly implanted, one on both the left and right intact tibia of 18 white New Zealand rabbits for 12 weeks, to allow for a surface interface study. The results demonstrate that the micro-discontinuities on the upper surface of internal steel fixation plates reduced the presence of liquid filled voids within soft-tissue capsules. The micro-discontinuities on the plate under-surface increased bony integration without the presence of fibrous tissue interface. These results support the hypothesis that the fibrous capsule and the liquid filled void formation occurs mainly due to lack of micro-discontinuities on the polished smooth steel plates and that bony integration is increased to surfaces with higher amounts of micro-discontinuities. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 705-715, 2018.

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The effect of a collagen-elastin matrix on adhesion formation after flexor tendon repair in a rabbit model

Cited by 17 publications

References 33 publications

Proteins and Peptides as Important Modifiers of the Polymer Scaffolds for Tissue Engineering Applications—A Review

Proteins and Peptides as Important Modifiers of the Polymer Scaffolds for Tissue Engineering Applications—A Review

Does methylene blue reduce adhesion during the healing process after tendon repair?

Influence of steel implant surface microtopography on soft and hard tissue integration

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