The use of mass spectrometry in organic analysis

Eliel, Ernest L.; Prosser, Thomas; Young, George W.

doi:10.1021/ed034p72

Cited by 6 publications

(1 citation statement)

References 13 publications

(15 reference statements)

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“…Organic mass spectrometry began its strong growth in the 1950s (1), but expense and complexity of instrumentation limited access to undergraduates until relatively recently. Research use of gas chromatography-mass spectrometry (GC-MS) was well developed by the 1970s.…”

Section: Introductionmentioning

confidence: 99%

Mass Spectral Fragmentation Patterns of Deuterated Butyl and Ethyl Acetates: An Easy Microscale Isotopic Labeling Experiment

Zahedkargaran

Smith

2001

J. Chem. Educ.

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Gas chromatography-mass spectrometry has become part of the routine characterization of compounds in the organic lab. We have developed an experimentally uncomplicated microscale experiment that illustrates the use of isotopic labeling, in this case deuteration, to help confirm and interpret mass spectral fragmentation patterns in butyl acetate and ethyl acetate. In this way, many fragments can be confirmed experimentally, not just by going on a basis of plausibility or by "looking them up". Given the expense of the deuterated reagents required, as well as the need for a series of chromatographic runs, a microscale procedure and sharing of data are most appropriate.

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Section: Introductionmentioning

confidence: 99%

Mass Spectral Fragmentation Patterns of Deuterated Butyl and Ethyl Acetates: An Easy Microscale Isotopic Labeling Experiment

Zahedkargaran

Smith

2001

J. Chem. Educ.

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Spectroscopy of Amines of Pharmaceutical Interest

Eisdorfer¹,

Warren²,

Zarembo³

1968

Journal of Pharmaceutical Sciences

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A Mass Spectrometer in Every Fume Hood

McBride

Verbeck

2018

J. Am. Soc. Mass Spectrom.

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Since their inception, mass spectrometers have played a pivotal role in the direction and application of synthetic chemical research. The ability to develop new instrumentation to solve current analytical challenges in this area has always been at the heart of mass spectrometry, although progress has been slow at times. Herein, we briefly review the history of how mass spectrometry has been used to approach challenges in organic chemistry, how new developments in portable instrumentation and ambient ionization have been used to open novel areas of research, and how current techniques have the ability to expand on our knowledge of synthetic mechanisms and kinetics. Lastly, we discuss the relative paucity of work done in recent years to embrace the concept of improving benchtop synthetic chemistry with mass spectrometry, the disconnect between applications and fundamentals within these studies, and what hurdles still need to be overcome. Graphical Abstract.

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The use of mass spectrometry in organic analysis

Abstract: Examines the applications of mass spectroscopy to organic chemistry, particularly with respect to quantitative analysis.

Cited by 6 publications

References 13 publications

Mass Spectral Fragmentation Patterns of Deuterated Butyl and Ethyl Acetates: An Easy Microscale Isotopic Labeling Experiment

Mass Spectral Fragmentation Patterns of Deuterated Butyl and Ethyl Acetates: An Easy Microscale Isotopic Labeling Experiment

Spectroscopy of Amines of Pharmaceutical Interest

A Mass Spectrometer in Every Fume Hood

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