Spectroscopy of Amines of Pharmaceutical Interest

Combining enabling formulation strategies to generate supersaturated solutions of delamanid: In situ salt formation during amorphous solid dispersion fabrication for more robust release profiles

“…Methylene groups next to the nitrogen atom in the tertiary amine group of the free base resulted in bands at 2816 cm −1 which were absent from the salt spectra. The protonation of the tertiary amine group increased the C-H binding constant, displacing these bands to a higher frequency region, causing them to overlap with other bands in this spectral range (such as C-H stretch aromatic and aliphatic) [41] , [42] , [43] , [44] .…”