1982
DOI: 10.1016/s0002-9378(16)32529-7
|View full text |Cite
|
Sign up to set email alerts
|

The use of magnesium sulfate as the primary tocolytic agent to prevent premature delivery

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

0
6
0

Year Published

1988
1988
2014
2014

Publication Types

Select...
7
2
1

Relationship

0
10

Authors

Journals

citations
Cited by 63 publications
(6 citation statements)
references
References 7 publications
0
6
0
Order By: Relevance
“…In this regard, magnesium, one of the trace elements, has become the subject of interest [ 15 ]. Hypomagnesaemia during pregnancy decreases the magnesium level in myometrium and a low magnesium concentration in pregnant human myometrium could be a cause of preterm labour [ 16 18 ]. Rising serum magnesium level serves to relax the uterine smooth muscle, thereby providing the basis for the previous use of magnesium sulphate as a tocolytic agent in pregnancy in North America [ 14 , 19 ], although a Cochrane systematic review has now concluded that it is ineffective as a tocolytic agent and may even be harmful to the unborn baby [ 20 ].…”
Section: Introductionmentioning
confidence: 99%
“…In this regard, magnesium, one of the trace elements, has become the subject of interest [ 15 ]. Hypomagnesaemia during pregnancy decreases the magnesium level in myometrium and a low magnesium concentration in pregnant human myometrium could be a cause of preterm labour [ 16 18 ]. Rising serum magnesium level serves to relax the uterine smooth muscle, thereby providing the basis for the previous use of magnesium sulphate as a tocolytic agent in pregnancy in North America [ 14 , 19 ], although a Cochrane systematic review has now concluded that it is ineffective as a tocolytic agent and may even be harmful to the unborn baby [ 20 ].…”
Section: Introductionmentioning
confidence: 99%
“…Our success rates are comparable to those reported in the literature. [10][11][12][15][16][17][18] Our second question addressed the more important issue of the impact on neonatal outcome and maternal morbidity. We hypothesized that aggressive management to delay delivery would be justified if we were able to demonstrate improved neonatal outcome with minimal maternal morbidity.…”
Section: Discussionmentioning
confidence: 99%
“…The results of the present investigation demonstrate for the first time that Mg does pass the BBB in developing swine within the first postnatal month, and to a greater extent in the younger than in the older animals. This is clinically relevant because neonatal hypermagnesia can occur as a consequence of treatment of the mother with Mg; for example, as a tocolytic agent to prevent premature delivery (9,10). Excess Mg produces a wide variety of effects including skeletal muscle paralysis, respiratory depression, and changes in cardiovascular function.…”
Section: Discussionmentioning
confidence: 99%