The Use of Lipofilling to Treat Congenital Hypoplastic Breast Anomalies

Derder, M. E. M.; Whitaker, Iain S.; Boudana, David; Marchac, Alexandre; Hivelin, Mikaël; Mattar, Nadia; Lepage, C.; Claude, Olivier; Benjoar, Marc-David; Bosc, Romain; Lantieri, Laurent

doi:10.1097/sap.0b013e31827fb3b7

Cited by 30 publications

(8 citation statements)

References 34 publications

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“…Reconstructive options to improve symmetry in men include bespoke prostheses, pedicled flaps such as latissimus dorsi or omental flaps, free-flaps and lipomodelling [6][7][8]. The absence of a muscular plane can result in unnatural-looking results with prostheses and autologous flap-based reconstructions convey variable donor and recipient site morbidity.…”

Section: Discussionmentioning

confidence: 98%

Concurrent Poland’s syndrome and gynaecomastia: achieving the balance using lipomodelling

2015

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Section: Discussionmentioning

confidence: 98%

Concurrent Poland’s syndrome and gynaecomastia: achieving the balance using lipomodelling

2015

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“…The ideal filler for soft tissue augmentation should be easy to obtain, non-carcinogenic, non-teratogenic, non-inflammatory and non-migratory and with a good cost-efficiency ratio [ 8 , 9 ]. It must also have predictable and persistent results and have minimal or no risk of transmitting infectious diseases.…”

Section: ⧉ Discussionmentioning

confidence: 99%

The significance of erythropoietin and insulin administration on survival of fat tissue after autologous fat transplantation in Wistar rats. An experimental study

Olaru

Sava²,

Tamaş³

et al. 2021

Rom J Morphol Embryol

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Autologous fat transfer is widely used by plastic surgeons for aesthetic and reconstructive purpose, but it has a great disadvantage because of its high variability rate of resorption. Numerous studies have examined the use of different agents to increase the viability of fat grafts. The results were discouraging because the use of a single angiogenic factor to stimulate fat graft angiogenesis may be inappropriate. We proposed to use two pharmacological factors, erythropoietin (EPO) and insulin (INS), in order to decrease the resorption rate, to improve graft vascularization, and to reduce the number of complications. Twenty-four Wistar male rats were randomly divided in four groups (I-IV) of six animals each. The rats belonging to control group were given autologous transfer of simple fat. In group II, the graft was improved with EPO, in group III with INS, and in group IV both pharmacological agents were administered. Histological evaluation of the grafts at two months after injection demonstrated adipocyte survival in all four groups. The volume of the graft has progressively decreased in all groups and the difference in graft volume at one and two months after transplantation was not significant. The highest maintenance of fat graft volume (95%) at two months was observed in group IV, followed by group II and group III. Necrotic cystic changes and increased fibrosis were most extensive in the control group. The combination of INS with EPO may have a synergistic and additive effect. Efficient administration and dose optimization of these growth factors are important things to consider in the future.

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“…A series of eight patients by Pinsolle et al reported 1–5 lipofillings necessary in combination with other procedures such as implants or flaps, in order to achieve sufficient volume and symmetry [ 16 ]. While lipofilling alone might be sufficient only in mild cases, it still has its role in the treatment of the more severely afflicted, by combining it with other procedures ( Figure 1 , Figure 3 , Figure 4 and Figure 5 ) [ 51 , 52 ]. The disadvantages of size and atrophy in muscular flaps for example can be safely compensated by additional autologous fat transfer [ 31 , 53 ]; 77.3% of our reported cases received at least one treatment of lipofilling with an average volume of 205 mL.…”

Section: Discussionmentioning

confidence: 99%

Development of A Surgical Treatment Algorithm for Breast Reconstruction in Poland Syndrome Patients Considering Severity, Sex, and BMI

Mahrhofer

Schoeller

Casari

et al. 2021

JCM

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Introduction: Poland syndrome is a rare, challenging combination of chest wall and breast deformities for reconstructive surgeons and selecting the treatment can prove difficult. This study aims to help surgeons in choosing the best viable option for treatment by sharing our institutional experience and proposing a guiding algorithm. Methods: A retrospective analysis of all patients with Poland syndrome undergoing treatment for breast and chest wall deformities at a single institution between December 2011 and May 2020 was performed. Medical charts were reviewed to allow for a description of patient demographics, treatment modalities and complications. A treatment algorithm to aid in selecting the adequate reconstructive option based on our institutional experience was formulated. Results: A total of 22 patients (six male, 16 female) were identified who received treatment for Poland Syndrome related deformities. Nine received microsurgical free flap reconstruction (three Deep Inferior Epigastric Perforator flaps, six Transverse Myocutaneous Gracilis flaps), two received reconstruction with a local flap (two Latissimus dorsi flaps), nine received implant based reconstruction, and two were treated with autologous free fat transfer only (17 in combination with other surgical methods). Conclusion: Free flap reconstruction with the TMG flap is a valid option for patients with low Body Mass Index (BMI), while Deep Inferior Epigastric Perforator flaps should be considered for patients with a higher BMI. Autologous free fat transfer proves to be a safe and efficient treatment option in mild cases of Poland syndrome for male and female patients, in combination with or without implant based reconstructive surgery. Multicentre studies should be conducted to achieve higher case numbers of this rare disease and support clinical decisions with more data.

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The Use of Lipofilling to Treat Congenital Hypoplastic Breast Anomalies

Abstract: Our preliminary results using lipofilling to treat young patients with breast hypoplasia with lipofilling are very encouraging. The authors believe it is an alternative of choice for the correction of the young woman's breast deformities if the avoidance of scarring is preferred.

Cited by 30 publications

References 34 publications

Concurrent Poland’s syndrome and gynaecomastia: achieving the balance using lipomodelling

Concurrent Poland’s syndrome and gynaecomastia: achieving the balance using lipomodelling

The significance of erythropoietin and insulin administration on survival of fat tissue after autologous fat transplantation in Wistar rats. An experimental study

Development of A Surgical Treatment Algorithm for Breast Reconstruction in Poland Syndrome Patients Considering Severity, Sex, and BMI

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