The use of laminin modified linear ordered collagen scaffolds loaded with laminin-binding ciliary neurotrophic factor for sciatic nerve regeneration in rats

Cao, Jiani; Sun, Changkai; Zhao, Hui; Xiao, Zhifeng; Chen, Bing; Gao, Jian; Zheng, Tiezheng; Wu, Wei; Wu, Shuang; Wang, Jingyu; Dai, Jianwu

doi:10.1016/j.biomaterials.2011.02.020

Cited by 126 publications

(97 citation statements)

References 47 publications

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“…In this respect, bioscaffolds yielded by cryogelation of gelatin or dextran linked to laminin [351] or PCL-chitosan scaffolds with surfaces modified via the crosslinking of laminin [352] could serve as versatile substrates with excellent mechanical and surface properties for in vivo cell delivery, resulting in highly neuroregenerative properties for nerve tissue engineering applications. Furthermore, the application of laminin-modified linear ordered collagen biomaterials loaded with laminin-binding ciliary neurotrophic factor (CNTF) was beneficial for sciatic nerve regeneration and functional recovery when tested in a rat sciatic-nerve transection model [353]. Data obtained from this study suggest that the modification of linear ordered collagen scaffolds with laminin guided axon growth, as the laminin-binding domain fused to the N-terminus of CNTF retained more CNTF on the bioscaffolds and additionally enhanced nerve regeneration and functional recovery.…”

Section: Human Tissue Ecm-based Biomaterialsmentioning

confidence: 99%

Advancing biomaterials of human origin for tissue engineering

Chen

Liu

2016

Progress in Polymer Science

875

513

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Biomaterials have played an increasingly prominent role in the success of biomedical devices and in the development of tissue engineering, which seeks to unlock the regenerative potential innate to human tissues/organs in a state of deterioration and to restore or reestablish normal bodily function. Advances in our understanding of regenerative biomaterials and their roles in new tissue formation can potentially open a new frontier in the fast-growing field of regenerative medicine. Taking inspiration from the role and multi-component construction of native extracellular matrices (ECMs) for cell accommodation, the synthetic biomaterials produced today routinely incorporate biologically active components to define an artificial in vivo milieu with complex and dynamic interactions that foster and regulate stem cells, similar to the events occurring in a natural cellular microenvironment. The range and degree of biomaterial sophistication have also dramatically increased as more knowledge has accumulated through materials science, matrix biology and tissue engineering. However, achieving clinical translation and commercial success requires regenerative biomaterials to be not only efficacious and safe but also cost-effective and convenient for use and production. Utilizing biomaterials of human origin as building blocks for therapeutic purposes has provided a facilitated approach that closely mimics the critical aspects of natural tissue with regard to its physical and chemical properties for the orchestration of wound healing and tissue regeneration. In addition to directly using tissue transfers and transplants for repair, new applications of human-derived biomaterials are now focusing on the use of naturally occurring biomacromolecules, decellularized ECM scaffolds and autologous preparations rich in growth factors/non-expanded stem cells to either target acceleration/magnification of the body's own repair capacity or use nature's paradigms to create new tissues for restoration. In particular, there is increasing interest in separating ECMs into simplified functional domains and/or biopolymeric assemblies so that these components/constituents can be discretely exploited and manipulated for the production of bioscaffolds and new biomimetic biomaterials. Here, following an overview of tissue auto-/allo-transplantation, we discuss the recent trends and advances as well as the challenges and future directions in the evolution and application of human-derived biomaterials for reconstructive surgery and tissue engineering. In particular, we focus on an exploration of the structural, mechanical, biochemical and biological information present in native human tissue for bioengineering applications and to provide inspiration for the design of future biomaterials.

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Section: Human Tissue Ecm-based Biomaterialsmentioning

confidence: 99%

Advancing biomaterials of human origin for tissue engineering

Chen

Liu

2016

Progress in Polymer Science

875

513

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“…The walking behavior of rats was evaluated to measure the nerve recovery. After implantation for 2, 4, 8, and 12 weeks, walking track was analyzed by measuring the SFI (n=6) using a method described in the literature37 . Briefly, the sciatic function index (SFI, n=6) was calculated as: SFI = experimental paw length), NPL (normal paw length), ETS (operated experimental…”

mentioning

confidence: 99%

Nerve Guidance Conduits from Aligned Nanofibers: Improvement of Nerve Regeneration through Longitudinal Nanogrooves on a Fiber Surface

Huang

Ouyang

Niu

et al. 2015

ACS Appl. Mater. Interfaces

124

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A novel fibrous conduit consisting of well-aligned nanofibers with longitudinal nanogrooves on the fiber surface was prepared by electrospinning and was subjected to an in vivo nerve regeneration study on rats using a sciatic nerve injury model. For comparison, a fibrous conduit having a similar fiber alignment structure without surface groove and an autograft were also conducted in the same test. The electrophysiological, walking track, gastrocnemius muscle, triple-immunofluorescence, and immunohistological analyses indicated that grooved fibers effectively improved sciatic nerve regeneration. This is mainly attributed to the highly ordered secondary structure formed by surface grooves and an increase in the specific surface area. Fibrous conduits made of longitudinally aligned nanofibers with longitudinal nanogrooves on the fiber surface may offer a new nerve guidance conduit for peripheral nerve repair and regeneration.

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“…Some examples include collagen and crosslinked laminin scaffolds, [ 43 ] collagen-PCL electrospun scaffolds, [ 44 ] and chitosan and PLA scaffolds. [ 45 ] The interface between the internal and external environments also very infl uences regeneration and the integration of a material.…”

Section: Natural Materialsmentioning

confidence: 99%

Recent Strategies in Tissue Engineering for Guided Peripheral Nerve Regeneration

Belanger

Dinis

Sami

et al. 2016

Macromolecular Bioscience

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The repair of large crushed or sectioned segments of peripheral nerves remains a challenge in regenerative medicine due to the complexity of the biological environment and the lack of proper biomaterials and architecture to foster reconstruction. Traditionally such reconstruction is only achieved by using fresh human tissue as a surrogate for the absence of the nerve. However, recent focus in the field has been on new polymer structures and specific biofunctionalization to achieve the goal of peripheral nerve regeneration by developing artificial nerve prostheses. This review presents various tested approaches as well their effectiveness for nerve regrowth and functional recovery.

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The use of laminin modified linear ordered collagen scaffolds loaded with laminin-binding ciliary neurotrophic factor for sciatic nerve regeneration in rats

Cited by 126 publications

References 47 publications

Advancing biomaterials of human origin for tissue engineering

Advancing biomaterials of human origin for tissue engineering

Nerve Guidance Conduits from Aligned Nanofibers: Improvement of Nerve Regeneration through Longitudinal Nanogrooves on a Fiber Surface

Recent Strategies in Tissue Engineering for Guided Peripheral Nerve Regeneration

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