The Use of Ketamine in Neuropathic Pain

O’Brien, Sarah Lee; Pangarkar, Sanjog; Prager, Joshua P.

doi:10.1007/s40141-014-0045-2

Cited by 8 publications

(5 citation statements)

References 112 publications

(152 reference statements)

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“…3 Ketamine has been shown to be efficacious in treating MDD and posttraumatic stress disorder, and for the long-term management of chronic pain disorders, including fibromyalgia and many neuro pathic conditions. [4][5][6][7] Esketamine is an intranasal formulation of ketamine that is FDA-approved for treatment-resistant depression. 8 There is scant literature describing using ketamine for treating catatonia.…”

Section: Ketamine's Utility In Psychiatrymentioning

confidence: 99%

Ketamine for acute catatonia: A case report

Kobayashi¹

2021

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Section: Ketamine's Utility In Psychiatrymentioning

confidence: 99%

Ketamine for acute catatonia: A case report

Kobayashi¹

2021

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“…Oral ketamine has been successfully used to treat central neuropathic pain as well as post stroke and thalamic pain, which were refractory to conventional pain treatments in recently published case reports. 53,54 However, the side effects of ketamine such as dysphoria, hallucinations, and paranoid feelings were attenuated by the concurrent use of benzodiazepines.…”

Section: Analgosedation Regimensmentioning

confidence: 99%

Ketamine: A Neuroanesthesiologist's Friend or Foe?

Luthra

Rath

2018

Journal of Neuroanaesthesiology and Critical Care

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Ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, introduced into clinical practice six decades ago, has often been the worst fear of a neuroanesthesiologist due to its concerns of causing a rise in intracranial pressure and increasing cerebral blood volume. However, the recent literature clarifies that it may have a beneficial role, even in neurosurgical patients, because of its propensity to cause neuroprotection through antiglutamatergic action on the NMDA receptors in the ischemic brain. Apart from having an anticonvulsive role in refractory status epilepticus, its inherent property of increasing blood flow to the ischemic areas offers protection to the penumbral zone, thus preventing secondary brain injuries. Also, it has been widely used as an analgesic at subanesthetic doses post spine surgeries. Recently, enough scientific evidence has been published in favor of ketamine establishing the fact that it does not cause a rise in intracranial pressure when the patient is mechanically ventilated and normocarbia is maintained. It has also been used during evoked potential monitoring as it amplifies signals even under general anesthesia and proves to be quite effective during neuromonitoring. However, its adverse effects of increasing muscle tone, excessive salivation, emergence delirium, agitation, and “out of body” experiences with long-term psychomimetic effects and potential to cause addiction have precluded its widespread use.This review on ketamine summarizes the benefits of using it in neurosurgical anesthesia with the aim of removing the fears we had in the past, which did not seem to be evidence based.

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“…Regarding the use of ketamine, its analgesic effect is known to be mediated by blockage of NMDA receptors, which are directly involved in nociceptive transmission and which have also been involved in opioid tolerance mechanisms [47]. Inhibition of tolerance has been demonstrated in test animals with the use of noncompetitive antagonists of NMDA receptors such as ketamine [48].…”

Section: What Strategies Can Be Implemented?mentioning

confidence: 99%

Management of acute pain in patients on treatment with opioids

Andrés¹,

Fabregat-Cid²,

Asensio-Samper³

et al. 2015

Pain Management

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The use of opioids for both benign and cancer-related chronic pain has increased exponentially over the last few years. For this reason, increasing numbers of such patients are presenting for surgery. It is known that continuous use of opioids is associated with an increase in postoperative analgesic requirements. This is believed to be mediated by the development of tolerance and opioid-induced hyperalgesia. Patients treated with opioids have special needs in the perioperative setting and it is the anesthesiologist's responsibility to manage these needs optimally. The aim of the present paper is to briefly orient the reader in the management of postoperative pain in patients chronically treated with licit opioids.

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The Use of Ketamine in Neuropathic Pain

Cited by 8 publications

References 112 publications

Ketamine for acute catatonia: A case report

Ketamine for acute catatonia: A case report

Ketamine: A Neuroanesthesiologist's Friend or Foe?

Management of acute pain in patients on treatment with opioids

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