2020
DOI: 10.1080/17512433.2020.1796637
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The use of isotretinoin for acne – an update on optimal dosing, surveillance, and adverse effects

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Cited by 87 publications
(99 citation statements)
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“…Like other retinoates, isotretinoin's lipophilic characteristic leads to a wide range of absorption levels when consumed without food. When taking them with food, the bioavailability (measured as mean maximum plasma concentration and the area under the 'plasma concentration-time' curve) increases, and the variability decreases [9,10].…”
Section: Pharmacokineticsmentioning
confidence: 99%
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“…Like other retinoates, isotretinoin's lipophilic characteristic leads to a wide range of absorption levels when consumed without food. When taking them with food, the bioavailability (measured as mean maximum plasma concentration and the area under the 'plasma concentration-time' curve) increases, and the variability decreases [9,10].…”
Section: Pharmacokineticsmentioning
confidence: 99%
“…Retinoid can induce or suppress the expression of various genes and play an essential role in the cellular process. The mechanism of action includes normalizing follicular hyperkeratinization, decreasing the production of cytokeratin 1, 10, 14, filaggrin, matrix metallopeptidases (MMPs), and toll-like receptor 2 (TLR-2), and increasing the production of cytokeratin 7, 13, 19, laminina B1, and IL-1 [9,20].…”
Section: Isotretinoin Mechanism Of Actionmentioning
confidence: 99%
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“…Isotretinoin acts on the sebaceous glands, reducing their activity; it promotes normalization of keratinization and of tissue matrix metalloproteinase; and it reduces inflammation and Cutibacterium acnes growth. 2 Cheilitis, dry skin, erythema, itching, peeling, bruising, eczematous reactions, conjunctivitis, dry eyes, and eyelid inflammation are the most common adverse effects ([1/10). 2 However, as reported by Cunningham et al, 1 we also describe in our experience the involvement of the genital region, although patients voluntarily do not report such symptoms.…”
mentioning
confidence: 99%
“…2 Cheilitis, dry skin, erythema, itching, peeling, bruising, eczematous reactions, conjunctivitis, dry eyes, and eyelid inflammation are the most common adverse effects ([1/10). 2 However, as reported by Cunningham et al, 1 we also describe in our experience the involvement of the genital region, although patients voluntarily do not report such symptoms. 1 Forty patients in treatment with only isotretinoin (26 female and 14 male patients; mean age, 23.1 years) at our outpatient specific service for acne from February to August 2020 were questioned for the appearance of any effects on the genital area.…”
mentioning
confidence: 99%