Systemic pharmacological treatments for acne: an overview of systematic reviews

Costa, Caroline Sousa; Bagatin, Ediléia; Yang, Zhirong; Pacheco, Rafael Leite; Magin, Parker; Santos, Luiza de Sá Urtiga; Pereira, Tiago Assis; Riera, Rachel

doi:10.1002/14651858.cd014917

Cited by 2 publications

(15 citation statements)

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“…Oral isotretinoin is effective for moderate‐to‐severe acne and can inhibit hyperkeratosis, and sebum production and reduce the size of the sebaceous glands 6,8,17,22 …”

Section: Acne and Epidermal Barrier Dysfunctionmentioning

confidence: 99%

“…When recommending treatments, physicians should consider the psychosocial aspects of acne (e.g., depression, mood effects of drugs such as oral contraceptives and isotretinoin) and physical aspects such as xerosis 6,8,17,18,19,20,22 …”

Section: Acne and Epidermal Barrier Dysfunctionmentioning

confidence: 99%

“…21 Topical anti-androgens and systemic anti-androgens are effective against acne. 6,8,17,22,23 Clascoterone cream 1%, an androgen receptor inhibitor, can reduce sebum and is indicated for the topical treatment of acne in males and females 12 years of age and older. 24 Statement 4.…”

Section: Literature Reviewmentioning

confidence: 99%

“…[6][7][8] Oral isotretinoin is effective for moderate-to-severe acne and can inhibit hyperkeratosis, and sebum production and reduce the size of the sebaceous glands. 6,8,17,22 When recommending treatments, physicians should consider the psychosocial aspects of acne (e.g., depression, mood effects of drugs such as oral contraceptives and isotretinoin) and physical aspects such as xerosis. 6,8,17,18,19,20,22 Prompt diagnosis and initiation of treatment may prevent emotional stress and possible sequelae such as post-inflammatory hyperpigmentation (PIH) and scarring.…”

Section: Literature Reviewmentioning

confidence: 99%

“…6,8,17,22 When recommending treatments, physicians should consider the psychosocial aspects of acne (e.g., depression, mood effects of drugs such as oral contraceptives and isotretinoin) and physical aspects such as xerosis. 6,8,17,18,19,20,22 Prompt diagnosis and initiation of treatment may prevent emotional stress and possible sequelae such as post-inflammatory hyperpigmentation (PIH) and scarring. 6,7,8,17,25 The clinician should inform the patient about acne-related sequelae such as PIH and scarring to avoid risk factors and promote treatment and maintenance therapy adherence.…”

Section: Literature Reviewmentioning

confidence: 99%

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Insights into acne and the skin barrier: Optimizing treatment regimens with ceramide‐containing skincare

Schachner,

Alexis,

Andriessen

et al. 2023

J of Cosmetic Dermatology

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IntroductionAcne is a common, complex, multifactorial inflammatory skin disease associated with epidermal barrier dysfunction. Beginning in childhood, acne affects many adolescents and adults. Acne is associated with lower self‐esteem, anxiety, and depression and may cause scars and pigmentary sequelae. The review explores the relationships between acne and the skin barrier function and discusses nuances in the prevention, treatment, and maintenance of acne and its impact on the skin barrier.MethodsThe advisors' previous publications addressed prescription and nonprescription pediatric acne treatment and skincare using cleansers, moisturizers, and a practical algorithm for treatment and maintenance, including skincare recommendations for pediatric acne patients and an algorithm for skin of color patients with acne.Before the meeting, literature was culled on the relationship between the skin barrier and acne and current best practices in acne, addressing prescription and nonprescription acne products and skincare as monotherapy, adjunctive, and maintenance treatment.ResultsAfter discussing 13 draft statements, the advisors applied the selected literature and drew from their clinical knowledge and experience, and agreed on five statements. The follicular epithelial barrier is directly involved with changes that occur during both comedogenesis and in stages of inflammation, especially with follicular rupture compromising the barrier's integrity. In acne‐affected skin, sebaceous glands are larger, sebum excretion and filaggrin expression higher, and stratum corneum lipids are reduced.Educating patients and clinicians about inflammation's central role in acne and measures to reduce inflammation is essential. Skin irritation and xerosis from acne and treatments lead to poor treatment adherence. A skincare regimen should be included in the acne prevention, treatment, and maintenance care regimen and should be ongoing. Maintenance treatment with topical agents and skincare using gentle ceramide‐containing cleansers and moisturizers is a recommended strategy after successfully controlling the disease.ConclusionsEpidermal barrier dysfunction contributes to acne exacerbation. Using the appropriate treatment and skincare helps to minimize irritation and inflammation, enhance treatment adherence, and improve patient outcomes.

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“…Oral isotretinoin is effective for moderate‐to‐severe acne and can inhibit hyperkeratosis, and sebum production and reduce the size of the sebaceous glands 6,8,17,22 …”

Section: Acne and Epidermal Barrier Dysfunctionmentioning

confidence: 99%

Section: Acne and Epidermal Barrier Dysfunctionmentioning

confidence: 99%